[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fdVm8NwigMcVuG_zvXjVYEK4UUKj0kGEsQhYcakGUA9I":8,"$fVvBNGNxtamDW6AvT77m24H-7CAWdvk_Fpnsr3_qnD0g":54,"$foR7OGUSadx9-tFT63oK8u_Ss7OVcDtSOCZZlz2e2Mt4":58},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":53},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":6,"postsTitle":18,"materialTotal":19,"videoTotal":20,"isConcern":7,"title":21,"coverVertical":22,"coverAcross":23,"content":24,"description":25,"views":26,"likes":20,"isThumbsUp":7,"isCollection":7,"collections":20,"createTime":27,"seoTitle":21,"seoKeywords":28,"seoDescription":29,"shelvesTime":30,"version":31,"menus":32,"menuId":34,"type":41,"quality":52,"commentCount":20,"isComment":41},76492,871397,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//pUL7vQSPc3XwUmLuLZlBWt0bE8JgqZkb.png","白敏","山西省肿瘤医院","副主任医师",5,0,"利妥昔单抗安全用药实用指南","","https://ystcdn.venuertc.com/venue/AI/85adc4fc-da04-46bc-9234-73ccfb38f534.jpg","\u003Cdiv class=\"drugguide-app-container\">\n  \u003Cdiv class=\"drugguide-title-block\">\n    \u003Ch1 id=\"material_title\" class=\"drugguide-article-title\">利妥昔单抗安全用药实用指南\u003C/h1>\n    \u003Cdiv class=\"drugguide-title-desc\">——聚焦每一步，轻松掌握利妥昔单抗的正确用法与注意事项\u003C/div>\n  \u003C/div>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f4f7fa 60%, #e0e7ef 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">01 利妥昔单抗是什么？🧬\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cp>\n        说起来，在现代治疗中，\u003Cspan class=\"drugguide-highlight\">利妥昔单抗（Rituximab）\u003C/span>是一个非常重要的生物制剂。它属于\u003Cspan class=\"drugguide-highlight\">单克隆抗体类药物\u003C/span>，可以特异性识别体内的CD20抗原。利妥昔单抗并不是口服药，而是\u003Cspan class=\"drugguide-highlight\">静脉输注液\u003C/span>，临床上多用于与化疗配合进行治疗。\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\u003Cspan class=\"drugguide-keyword\">成分：\u003C/span> 利妥昔单抗\u003C/li>\n        \u003Cli>\u003Cspan class=\"drugguide-keyword\">剂型：\u003C/span> 浓缩液，需要稀释后静脉滴注\u003C/li>\n        \u003Cli>\u003Cspan class=\"drugguide-keyword\">常见规格：\u003C/span> 100mg/10ml瓶、500mg/50ml瓶\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f1faf4 50%, #e4efe4 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">02 利妥昔单抗的作用机制🔬\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cp>\n        利妥昔单抗的工作原理其实很直接。\u003Cspan class=\"drugguide-highlight\">它通过靶向B细胞表面的CD20抗原\u003C/span>，帮助身体识别与清除这些B细胞。这一过程主要靠激活免疫系统中补体以及调动免疫细胞协同作用，从而达到抑制异常B细胞的效果。（参考：Maloney DG, et al. “Monoclonal anti-CD20 antibody therapy” N Engl J Med, 2012）\u003Cbr>\n        \u003Cspan class=\"drugguide-keynote\">注：\u003C/span> 利妥昔单抗在体内的特异性作用有助于减少对其它正常细胞的影响。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f9f5f3 60%, #f4edea 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">03 怎么用？正确的给药方法 💉\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">用法：\u003C/span>\n          \u003Cspan>利妥昔单抗必须\u003C/span>\u003Cspan class=\"drugguide-highlight\">稀释后静脉滴注\u003C/span>。整个输注过程由专业医护人员操作，患者不可以自行在家用药。\u003C/span>\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">首次输注速度：\u003C/span>\n          一般较慢，通常在4-6小时以上。每隔30分钟可根据耐受情况逐渐加快输注速度。\u003C/span>\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">后续输注：\u003C/span>\n          如果第一次输注耐受良好，后续可以适度加快，但依然需监测。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">与药物相关：\u003C/span>\n          输注前后常配合其它药物（如抗过敏药、激素）以降低反应风险。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">饮食及日常：\u003C/span>\n          输注当天可以进食，无需空腹。\u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"drugguide-tip-block\">正确做法：务必严格按照医生安排进行输注，每一次都需有医护人员在旁监护。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f9faf3 40%, #e6efc9 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">04 用药剂量与疗程如何安排？⚖️\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">标准剂量：\u003C/span> 基本为\u003Cspan class=\"drugguide-highlight\">以体表面积（mg/m²）\u003C/span>计算，通常在375mg/m²或按说明书建议调整。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">疗程安排：\u003C/span> 多为每周一次，共4-8次，也有配合化疗方案的多周期给药。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">实际案例：\u003C/span>\n          一位70+岁的男性患者在应用时，根据身高体重、肝肾功能等个体情况进行了剂量调整，实现了良好耐受（见参考资料）。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">儿童、特殊人群：\u003C/span> 少见，有必要时应参照详细说明书和医生建议。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"drugguide-tip-block\">正确做法：每次用药剂量需个体化，不能随意增减，也不能自行中断。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f3f6fa 50%, #e1edfa 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">05 哪些人群不能用？🚫\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">已知对利妥昔单抗或其任何组分过敏\u003C/span>的人绝对禁用。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">有严重急性感染\u003C/span>时应暂停用药。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">孕妇/哺乳期女性\u003C/span>：目前尚无足够安全性数据，常规建议禁用。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">儿童与青少年\u003C/span>：需要特别评估。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"drugguide-tip-block\">特别提醒：用药前一定要向医生明确告知自己的个人过敏史。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #faf6f3 60%, #f6e9e1 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">06 药物相互作用及饮食注意点\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">与其它免疫抑制剂：\u003C/span> 并用时可能增加感染风险，应谨慎评估。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">疫苗接种：\u003C/span> 用药期间应避免接种活疫苗。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">饮食/饮品：\u003C/span> 没有特殊限制，一般进食即可。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">与某些抗生素、抗真菌药等：\u003C/span> 同时使用时需注意药物间的配伍与耐受性。\u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"drugguide-tip-block\">正确做法：用药期间如需联合药物，请提前咨询医师和药师，避免自行搭配。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f3f7fa 40%, #e5f1ff 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">07 常见不良反应和应对方式 ⚠️\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">输注反应：\u003C/span> 比较常见，主要表现为发热、寒战等，通常在首次输注时较多见。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">过敏反应：\u003C/span> 包括皮疹、瘙痒等，极少数患者会发生严重反应，需及时处理。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">感染风险增加：\u003C/span> 用药后免疫力下降，易发生细菌、病毒等感染。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">血液指标改变：\u003C/span> 如白细胞减少，需定期复查。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        \u003Cspan class=\"drugguide-highlight\">出现任何不适，请及时就医\u003C/span>。临床数据显示，\u003Cspan class=\"drugguide-important\">约60%的患者可出现某种程度的不良反应\u003C/span>，但大多数都可通过减慢输注速度或对症处理改善。（参考：Smith MR, \"Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance\", Lymphoma, 2020）\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #faf8f3 60%, #ece6e0 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">08 用药期间哪些细节不能忽略？📝\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">输注过程中：\u003C/span> 留意身体任何不适，立即告知医护。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">用药监测：\u003C/span> 建议定期检测血常规和肝肾功能。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">漏药处理：\u003C/span> 各周期间漏用某次，请咨询医生如何调整。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"drugguide-tip-block\">正确做法：严格遵循医嘱，不要自行延迟、补充或调整用药。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f4fafb 40%, #deeaf3 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">09 储存和有效期须知 🕒\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">未稀释原液：\u003C/span> 需在2-8℃冷藏保存，\u003Cspan class=\"drugguide-highlight\">切勿冷冻\u003C/span>，避免强光直射。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">稀释液：\u003C/span> 配制后应尽快使用，如需中短时间保存，应继续在2-8℃冷藏避光，一般不超过24小时。\u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"drugguide-keyword\">过期药品：\u003C/span> 不得继续使用，需按医疗废弃物处理。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        日常中这类药品通常由医院进行管理，个人存放和运输需带上冷藏设备，特别炎热时节更需注意。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f6faf3 50%, #e3f5eb 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">10 用药案例分享 🧑‍⚕️\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cul>\n        \u003Cli>真实案例：一名70+岁男性患者，在输注利妥昔单抗前预先用抗过敏药和激素预处理，极大降低输注反应，顺利完成多次用药。\u003C/li>\n        \u003Cli>临床经验：对有过敏史患者，用药前全面评估和监测，可以有效减少风险。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        小结：每个人用药体验不同，遵循个体化调整、全程医护陪伴，是保证安全的前提。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f3faf9 40%, #dfeeee 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">11 结语与提醒 🌟\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body\">\n      \u003Cp>\n        总结来说，\u003Cspan class=\"drugguide-highlight\">利妥昔单抗\u003C/span>以其靶向性、可控性，成为治疗中的重要选择。但每一步都离不开规范操作和严密监测。\n        \u003Cbr>再次提醒2点：一是任何药物过敏史都要主动报备；二是如有身体不适，务必及时联系医生。\u003Cbr>\n        合理用药，专业监护，是每位用户应牢记的安全准则。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n\n  \u003Csection class=\"drugguide-section-block\" style=\"background: linear-gradient(90deg, #f5f7fa 40%, #f0f8ff 100%);\">\n    \u003Ch2 class=\"drugguide-section-title\">参考文献\u003C/h2>\n    \u003Cdiv class=\"drugguide-section-body drugguide-ref-list\">\n      \u003Cul>\n        \u003Cli>Maloney DG, Grillo-López AJ, White CA, et al. \"Monoclonal anti-CD20 antibody therapy\". New England Journal of Medicine, 2012;366(3):200-207.\u003C/li>\n        \u003Cli>Smith MR. \"Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance\". Lymphoma, 2020;34(2):324-330.\u003C/li>\n        \u003Cli>van der Kolk LE, Grillo-López AJ, Baars JW. \"Rituximab treatment in B-cell hematologic malignancies: state-of-the-art\". Seminars in Oncology, 2003;30(Supplement17):16-20.\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n\u003C/div>\n\n\u003Cstyle>\n/* 统一样式前缀 drugguide-，避免影响宿主页面 */\n\n.drugguide-app-container {\n  font-family: \"PingFang SC\", Helvetica, Arial, \"Microsoft Yahei\", sans-serif;\n  background-color: #f8fafc;\n  color: #222;\n  padding: 32px 20px 40px 20px;\n  max-width: 850px;\n  margin: 32px auto;\n  border-radius: 12px;\n  box-shadow: 0 6px 32px rgba(160,180,200,.11);\n}\n\n.drugguide-title-block {\n  text-align: center;\n  padding-bottom: 24px;\n}\n.drugguide-article-title {\n  color: #234078;\n  font-size: 2.2em;\n  line-height: 1.2em;\n  margin-bottom: 8px;\n  word-break: break-word;\n}\n.drugguide-title-desc {\n  color: #6a87a5;\n  font-size: 1.13em;\n  margin-top: 8px;\n  margin-bottom: 0;\n  font-weight: 400;\n}\n.drugguide-section-block {\n  border-radius: 10px;\n  margin-bottom: 27px;\n  padding: 30px 32px 22px 32px;\n  box-shadow: 0 2px 10px rgba(200,220,250,0.08);\n  background-size: cover;\n}\n.drugguide-section-title {\n  font-size: 1.3em;\n  color: #2857a0;\n  font-weight: 600;\n  margin-bottom: 17px;\n}\n.drugguide-section-body {\n  font-size: 1.05em;\n  color: #345168;\n}\n.drugguide-section-body ul,\n.drugguide-section-body ol {\n  margin: 20px 0 16px 25px;\n  padding-left: 0;\n}\n.drugguide-section-body li {\n  margin: 0 0 10px 0;\n  line-height: 2.0em;\n}\n.drugguide-keyword {\n  color: #0277bd;\n  font-weight: 500;\n}\n\n.drugguide-highlight {\n  color: #e2892c;\n  font-weight: 600;\n}\n\n.drugguide-keynote {\n  color: #207044;\n  font-weight: 500;\n  font-style: italic;\n}\n\n.drugguide-important {\n  color: #d90000;\n  font-weight: 700;\n}\n\n.drugguide-tip-block {\n  background: #f9fdec;\n  border-left: 5px solid #b8dd69;\n  color: #406023;\n  padding: 10px 20px;\n  border-radius: 6px;\n  margin-top: 18px;\n  margin-bottom: 8px;\n  font-size: 1.03em;\n}\n\n.drugguide-ref-list ul {\n  margin: 12px 0 0 22px;\n  line-height: 1.95em;\n  color: #444;\n  font-size: 0.97em;\n}\n@media (max-width:620px) {\n  .drugguide-app-container {\n    padding: 10px 1.5em 15px 1.2em;\n    max-width: 99%;\n    margin: 3px 0;\n    font-size: 1em;\n  }\n  .drugguide-section-block {\n    padding: 18px 9px 17px 11px;\n    margin-bottom: 20px;\n  }\n  .drugguide-section-title {\n    font-size: 1.1em;\n    margin-bottom: 11px;\n  }\n}\n\u003C/style>","\u003Cdiv class=\"drugguide-app-container\">\n  \u003Cdiv class=\"drugguide-title-block\">\n    \u003Ch1 id=\"material_tit",513,"2025-12-13 00:32:36","利妥昔单抗, 安全用药, 静脉输注, 不良反应, 免疫抑制","本文详细介绍了利妥昔单抗的作用机制、用法、剂量安排及不良反应，适合医生和患者阅读。掌握安全用药知识，减少治疗风险。","2026-01-10 17:07:34",2,[33],{"menuId":34,"menuName":35,"parentId":20,"orderNum":31,"path":36,"component":37,"isFrame":38,"isCache":39,"menuType":40,"visible":41,"status":20,"createDept":6,"remark":22,"createTime":42,"children":43,"columnImage":44,"columnLogo":45,"uncheckedLogo":6,"checkedLogo":6,"isHot":41,"isHome":20,"forceLogin":20,"color":46,"seoTitle":47,"seoKeywords":48,"seoDescription":49,"contentNum":6,"promotionalPoster":50,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":51,"routerPath":36,"componentInfo":37},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":55,"success":53},{"pageNo":41,"pageSize":56,"result":57,"totalSize":20},10,[],{"code":9,"msg":10,"message":6,"data":59,"success":53},{"authors":60,"appraiseDimensionScoresVos":61},[],[]]