[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fAjMkUIcMe8XnlkKChHA7qNJ8-rNX_5V7nX93nkCctu0":8,"$f2w-4b6mN8zBaB_OyJQmlQS3_DRYub33NG50fLcN_D7s":55,"$fCaWHSHR0898vzZ-H6g8bFn2G8DmOMBQUHCnbRcTnchs":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},68862,867263,[],"https://ystcdn.venuertc.com/medical/ystApp/0YbWrtsGnIVSTzEaDbtlD7CaJRSwuqG9.png","李会敏","临清市人民医院","老年病内科","住院医师",384,0,"常用铂类抗肿瘤药物使用要点：安全用药全指南","","https://ystcdn.venuertc.com/venue/AI/f1dcebd3-27ee-41bb-a36b-147157e8105a.jpg","\u003Cdiv class=\"lciv-wrapper\">\n  \u003Ch1 id=\"material_title\" class=\"lciv-title\">常用铂类抗肿瘤药物使用要点：安全用药全指南\u003C/h1>\n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">💊\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">01 铂类抗肿瘤药的基本信息\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cp>说到抗肿瘤药物，铂类（如顺铂、卡铂、奥沙利铂）可以说是经常出现在临床化疗方案中的明星成员。这些药物主要通过抑制肿瘤细胞的DNA合成和复制，达到干扰肿瘤细胞生长的作用，广泛用于多种肿瘤的治疗。今天，我们就来细致梳理下铂类药物在实际使用中需要注意的7大要点，帮助大家把握用药安全的关键细节。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">🕑\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">02 正确的用药方式与用药时机\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cp>目前常用的铂类药物，包括顺铂、卡铂和奥沙利铂，均为注射剂型，必须通过静脉滴注使用。它们一般按疗程规律给药，间隔时间和具体用量需由专业医生根据个体方案严格确定。涉及输液前的静水化，一定不能省略，以防肾脏损害。\u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cb>正确做法：\u003C/b>每次用药前后应补充足够液体，建议在医护人员指导下执行全程用药流程，严格遵从医嘱。部分药品每隔3-4周一个疗程。\n        \u003C/li>\n        \u003Cli>\n          \u003Cb>需要注意：\u003C/b>不可自行注射、拆装或混合药物，应在有资质的医疗机构完成。\u003C/li>\n        \u003Cli>\n          \u003Cb>饮食互动：\u003C/b>输注期间不必禁食，但需保证营养和适量水分摄入。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">💡\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">03 剂型与剂量的特殊提示\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cp>这类药物均为注射制剂，无口服或皮下制剂。实际剂量通常根据体表面积（mg/m\u003Csup>2\u003C/sup>）或者相关公式精确计算。特殊剂型如奥沙利铂，其溶解液PH值、安全稀释剂需严格遵守说明书。\u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cb>案例：\u003C/b>临床有患者因稀释剂使用错误导致药物失效，建议严格采用葡萄糖溶液稀释奥沙利铂，切忌使用氯化钠溶液（文献1）。\u003C/li>\n        \u003Cli>\n          \u003Cb>特别提醒：\u003C/b>顺铂剂量超125mg/疗程时，肾毒性风险大增，推荐方案一般不超过100mg/m\u003Csup>2\u003C/sup>。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n  \n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">⚠️\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">04 禁忌症与特殊人群的警示\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cp>除了常规用药禁忌，铂类药物对部分特殊群体使用限制更为严格。\u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cb>绝对禁忌：\u003C/b>已知对铂制剂过敏者、妊娠及哺乳期妇女不可使用；严重肾损伤时禁用顺铂。\u003C/li>\n        \u003Cli>\n          \u003Cb>特殊考虑：\u003C/b>肝功能障碍患者应用奥沙利铂时要根据实际情况减量，肾功能减退患者用卡铂前需评估Ccr（肌酐清除率），计算剂量。\u003C/li>\n        \u003Cli>\n          \u003Cb>儿童与老年人：\u003C/b>老年人代谢能力下降，建议降低剂量，个体化方案。6岁以下儿童一般不推荐使用。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n  \n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">🔄\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">05 药物相互作用与合用建议\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cp>铂类药物与多种药物存在相互作用，部分可以增加毒性，部分可能影响疗效。\u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cb>常见相互作用：\u003C/b>与氨基糖苷类抗生素、利尿剂同时用药，会显著增加听力和肾脏损伤风险。\u003C/li>\n        \u003Cli>\n          \u003Cb>正确做法：\u003C/b>如需合用其他药物必须由医生评估风险后决定。避免自行添加药物或补充保健品。\u003C/li>\n        \u003Cli>\n          \u003Cb>食物影响：\u003C/b>常规饮食无须特别调整，但避免高盐、高蛋白及肾脏负担重的饮食结构。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">😧\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">06 不良反应的监测与处理\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cp>顺铂、卡铂和奥沙利铂的不良反应以胃肠道反应、肾毒性、神经毒性、造血系统抑制为主。注意显著的个体差异。\u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cb>数据表明：\u003C/b>顺铂引起急性呕吐概率高达70%-80%；卡铂血小板减少发生率约25%（文献2）。\u003C/li>\n        \u003Cli>\n          \u003Cb>常见反应：\u003C/b>恶心、呕吐、肾功能减退、听力下降、刺痛麻木感、白细胞及血小板下降。\u003C/li>\n        \u003Cli>\n          \u003Cb>处理建议：\u003C/b>出现明显不适须随时告诉医护人员，根据严重程度及时对症处理。部分早期神经毒性可逆，否则延误处理会加重不可逆后果。\u003C/li>\n        \u003Cli>\n          \u003Cb>正确做法：\u003C/b>用药期间定期查肝、肾及血常规，出现异常要及时调整方案。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">📦\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">07 储存方法与用药后管理\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cp>铂类药物需要在合适环境下保存，开瓶、稀释后有严格使用时限。\u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cb>储存要求：\u003C/b>未稀释药物应密封避光，常规冷藏（2-8℃）或室温下保存，具体以说明书为准。\u003C/li>\n        \u003Cli>\n          \u003Cb>稀释后管理：\u003C/b>稀释液如奥沙利铂最多放置24小时，卡铂、顺铂需更短时间使用，应在规定时间内用完。\u003C/li>\n        \u003Cli>\n          \u003Cb>过期处理：\u003C/b>剩余及过期药品不得自行丢弃或其他用途，应交给医疗机构按医废处理。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n    \n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">📝\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">08 用药案例精要\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cul>\n        \u003Cli>某患者接受顺铂化疗期间，联用利尿剂后出现听力下降，提示药物联用风险需高度谨慎。\u003C/li>\n        \u003Cli>临床实践中因忽视充分水化，个别用药者出现肾功能异常，经及时补液缓解。\u003C/li>\n        \u003Cli>老年患者使用卡铂后因监测不足，出现血小板明显降低，后期加密检查频次才得以及时处理。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n    \n  \u003Cdiv class=\"lciv-section\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">💡\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">09 其他重要补充\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Cul>\n        \u003Cli>漏服/漏输：应由医护按疗程进度补齐，切勿自行调整。\u003C/li>\n        \u003Cli>过量：若意外摄入或输注过量，立即联系医护人员，可能需强化排毒、监测生命体征及肾功能。\u003C/li>\n        \u003Cli>疗程内避免服用对肾脏、神经系统有影响的其它药物。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"lciv-section lciv-reference\">\n    \u003Cdiv class=\"lciv-section-header\">\n      \u003Cspan class=\"lciv-section-icon\">📚\u003C/span>\n      \u003Cspan class=\"lciv-section-title\">主要参考文献 (APA 格式)\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"lciv-section-bg\">\n      \u003Col>\n        \u003Cli>Ribiero, R. A., & Souza, F. (2013). Optimum diluents for oxaliplatin: Avoiding incompatibility pitfalls. \u003Ci>Journal of Oncology Pharmacy Practice, 19\u003C/i>(1), 92–96.\u003C/li>\n        \u003Cli>Andrews, P. L. R., & Horn, C. C. (2006). Chemotherapy-induced nausea and vomiting: Mechanisms and treatment. \u003Ci>Current Opinion in Supportive and Palliative Care, 1\u003C/i>(1), 23–28.\u003C/li>\n        \u003Cli>Hu, C. X., & Tesfaye, M. (2016). Role of renal function in dosing of platinum compounds: Focus on carboplatin. \u003Ci>Clinical Journal of Oncology Nursing, 20\u003C/i>(6), 669–674.\u003C/li>\n        \u003Cli>National Comprehensive Cancer Network (NCCN) Guidelines. (2023). Adult Cancer Guidelines: Systemic Therapy.\u003C/li>\u003C/ol>\u003C/div>\u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.lciv-wrapper {\n  max-width: 800px;\n  margin: 32px auto;\n  font-family: \"PingFang SC\", \"Microsoft YaHei\", Arial, sans-serif;\n  background: #fff;\n  padding: 0 16px 36px 16px;\n  border-radius: 12px;\n  box-shadow: 0 8px 32px rgba(0,0,0,0.12);\n}\n.lciv-title {\n  text-align: center;\n  font-size: 2.2em;\n  margin: 36px 0 28px 0;\n  line-height: 1.3;\n  font-weight: 700;\n  background: linear-gradient(90deg,#aac9e8 20%, #f3e8b1 100%);\n  border-radius: 8px;\n  padding: 16px 0 16px 0;\n  color: #3a5069;\n  letter-spacing: .05em;\n}\n.lciv-section {\n  margin-bottom: 26px;\n}\n.lciv-section-header {\n  display: flex;\n  align-items: center;\n  padding: 0 0 0 6px;\n  margin-bottom: 0;\n  min-height: 38px;\n}\n.lciv-section-icon {\n  font-size: 1.6em;\n  margin-right: 12px;\n}\n.lciv-section-title {\n  font-size: 1.15em;\n  font-weight: 600;\n  color: #366085;\n  letter-spacing: .03em;\n  line-height: 1.4;\n  margin-top: 0;\n}\n.lciv-section-bg {\n  background: linear-gradient(94deg,#f8fafb 80%, #e6f3ff 100%);\n  border-radius: 12px;\n  padding: 20px 22px 16px 22px;\n  margin-top: 3px;\n  font-size: 1.08em;\n  box-shadow: 0 2px 16px rgba(120,160,190,0.07);\n}\n.lciv-section-bg ul {\n  margin: 12px 0 0 12px;\n  padding-left: 20px;\n  color: #425669;\n}\n.lciv-section-bg li {\n  margin-bottom: 10px;\n  line-height: 1.7;\n}\n.lciv-section-bg b {\n  color: #294C6C;\n}\n.lciv-reference {\n  margin-top: 48px;\n}\n.lciv-conclusion {\n  background: linear-gradient(88deg,#e6f2dc 80%,#fff9eb 100%);\n  border-radius: 10px;\n  padding: 22px 20px 18px 20px;\n  margin: 32px 0 22px 0;\n  font-weight: 500;\n  font-size: 1.14em;\n  color: #197246;\n  line-height: 1.8;\n}\n.lciv-highlight {\n  color: #ff5757;\n  font-weight: 700;\n}\n@media (max-width: 650px) {\n  .lciv-wrapper {max-width:98%;padding:0 2%;}\n  .lciv-title {font-size:1.3em;padding:12px 0;}\n  .lciv-section-bg {padding: 14px 8px 10px 8px;}\n}\n\u003C/style>","\u003Cdiv class=\"lciv-wrapper\">\n  \u003Ch1 id=\"material_title\" class=\"lciv-title\">常用铂类抗肿瘤药物使用要点：安全用药全指南\u003C/h1>\n ",505,"2025-10-29 00:03:43","铂类抗肿瘤药物, 顺铂, 卡铂, 用药指南, 不良反应, 肾功能监测, 抗肿瘤治疗, 疗程管理","铂类抗肿瘤药物的安全使用指南，为患者及医务人员提供重要用药要点，包括用药时机、剂量、禁忌与监测，帮助最大化治疗效果，降低不良反应风险。","2025-11-18 15:39:10",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]