[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$f7weku5palWJzrjCKVrzdqG80Ch8BUk0BNACm6u2sU9U":8,"$f5kf_WOGJMvvMHiiku2uwbQxUNV8QtR38L0mEb_zjUw8":55,"$f86lpa7nMNIVp9lLW3OlqCNYU1jlZZV3Jo8imgICnq8w":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},67181,867169,[],"https://ystcdn.venuertc.com/medical/ystApp/kNx4pjeIsrYX6ihoX9AYfYiqTKSMDvhX.png","刘建","赵县人民医院","肿瘤科","主治医师",82,0,"贲门癌III期放疗相关药品安全使用完全指南","","https://ystcdn.venuertc.com/venue/AI/c1356663-a224-4e38-b3ed-08fbde68d67e.jpg","\u003Cdiv class=\"drug-guide-wrapper\">\n  \u003Ch2 id=\"material_title\" class=\"drug-guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">贲门癌III期放疗相关药品安全使用完全指南\u003C/h2>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01 主要药品类别与基本应用 ⚕️\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      在贲门部放射治疗过程中，相关药品主要包括：\u003Cbr>\n      \u003Cul>\n        \u003Cli>抗肿瘤化疗药物（如顺铂、氟尿嘧啶CAP、紫杉醇等）\u003C/li>\n        \u003Cli>放疗增敏剂\u003C/li>\n        \u003Cli>止吐药及保护胃黏膜的药物\u003C/li>\n        \u003Cli>造血支持及抗感染药物\u003C/li>\n      \u003C/ul>\n      它们大多注射给药，也有部分口服或静脉滴注剂型。本文将结合实际用药细节，为大家梳理这类药品的安全使用要点，共7个环节帮您全面掌握。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02 药理作用机制简介 🧬\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cstrong>主要三类药品的作用原理:\u003C/strong>\n      \u003Cul>\n        \u003Cli>\u003Cstrong>化疗药物\u003C/strong>如\u003Ca href=\"#ref1\">顺铂\u003C/a>，通过与DNA结合，阻断肿瘤细胞的增殖及修复过程，从而起到抑制作用。\u003C/li>\n        \u003Cli>\u003Cstrong>放疗增敏剂\u003C/strong>能提升肿瘤细胞对放射线的反应，提高疗效。\u003C/li>\n        \u003Cli>\u003Cstrong>辅助药品\u003C/strong>如止吐药（5-HT3受体拮抗剂）、促消化和胃黏膜保护药，从副作用方向切入，帮助患者耐受药物。\u003C/li>\n      \u003C/ul>\n      这些机制决定了药物的按时使用和足剂量的重要性。不过，剂型不同、作用机制不同，相关用药细节也需分开掌握。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03 剂型选择和服用技巧 💊\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>注射剂（如顺铂、奥沙利铂）\u003C/strong>：\n          \u003Cdiv>正确做法：治疗中多以静脉滴注为主，由专业护士进行配置和输注，避免自行注射。\u003C/div>\n          \u003Cdiv>剂量和速度严格遵循医生和说明书，速度过快可引发刺激。\u003C/div>\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>口服剂型（如卡培他滨片、蒙脱石散）\u003C/strong>：\n          \u003Cdiv>正确服用：必须整片吞服，勿嚼碎或掰开（特别是肠溶片、缓释片），否则会影响药效或增加副作用。\u003C/div>\n          \u003Cdiv>部分分散剂应按说明书溶于温水，搅拌均匀后服用。\u003C/div>\n        \u003C/li>\n      \u003C/ul>\n      \u003Cstrong>饮水要求：\u003C/strong>服药时配以大量温开水（200-250ml），可减少对咽喉和食道的刺激。\u003Cbr>\n      \u003Cstrong>操作误区：\u003C/strong>不可用酸奶、牛奶、咖啡等饮品送服，避免影响药品吸收或引起不良反应。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04 用药时间与服药顺序的关键点 🕐\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>化疗药物：\u003C/strong>大多数需与放疗协同安排，由医护人员操作，不在家中自行服用；口服辅助药需严格按处方表定时间（如每日餐前、餐中或餐后）服用。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>止吐药物（如昂丹司琼、托烷司琼）：\u003C/strong>必须提前于化疗药使用20-30分钟，以达到最佳防护效果。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>胃黏膜保护剂：\u003C/strong>如需同时服用两种以上药物，建议彼此间隔30分钟，以免药物干扰影响吸收。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cdiv>有位患者在用药间隔不足时出现胃部不适，需严格按照用药指导执行分时段服用。\u003C/div>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05 药物相互作用和配伍禁忌 ⚠️\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>化疗药与其他药品：\u003C/strong>顺铂、奥沙利铂等可能与某些抗生素（如氨基糖苷类）、利尿剂联用时，肾毒性增加（\u003Ca href=\"#ref1\">Cohen & Lippard, 2001\u003C/a>）。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>止吐药与神经系统药物：\u003C/strong>与苯二氮卓类等同用时，应关注镇静作用增强。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>口服药-食物相关：\u003C/strong>如卡培他滨与食物同服，吸收率下降，建议餐后30分钟服用。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>不可合用：\u003C/strong>蒙脱石散和部分口服药物（如抗生素）应间隔2小时，否则吸附作用影响主药效果。\u003C/li>\n      \u003C/ul>\n      正确做法：如需联用多种药物，务必主动告知医生所有正在服用的药品及保健品，配伍用药听从专业指导。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06 不良反应识别及应急处理 🩺\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>顺铂/奥沙利铂类：\u003C/strong>可能导致肾功能损害、听力异常、感觉异常。正确做法：遵医嘱定期检查肾功能及血象，如出现耳鸣、手脚麻木等应及时复诊。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>卡培他滨（口服）：\u003C/strong>部分人出现手足皮肤反应。可外用保湿剂，持续严重时需联系医生调整剂量。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>止吐药：\u003C/strong>偶见头晕、便秘、口干等，通常短期内缓解。如出现明显嗜睡、反应迟钝，需暂停并及时联系医生。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>蒙脱石散：\u003C/strong>罕见便秘。多饮水可缓解。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cdiv>数据表明：顺铂常见毒性发生率高达60%-90%（\u003Ca href=\"#ref1\">Cohen & Lippard, 2001\u003C/a>）；口服化疗手足综合征发生率约6%-25%（\u003Ca href=\"#ref2\">Oostendorp et al., 2011\u003C/a>）。\u003C/div>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07 老年人、特殊人群用药调整 👵🏻🧑‍⚕️\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>老年患者：\u003C/strong>部分药品需根据肝、肾功能调整剂量，避免过量。顺铂首选以减量为原则（\u003Ca href=\"#ref3\">Siegel & Miller, 2017\u003C/a>）。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>孕妇及哺乳期：\u003C/strong>禁止随意使用多数化疗药品、放疗增敏剂，可对胎儿或婴儿健康造成风险。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>肝肾功能异常人群：\u003C/strong>多药品需个体化剂量调整或更换品种，剂量/间隔务必在专科医生指导下决定。\n        \u003C/li>\n      \u003C/ul>\n      正确做法：每次用药前告知医生您的基础疾病、用药史及最近体检结果。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">08 储存方法、有效期与弃药流程 🗃️\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      各类药物储存均需严格遵守说明书：\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>注射液/冻干粉：\u003C/strong>避光、密封，2-8°C冷藏（不可冷冻），启封后24小时内用完。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>片剂/胶囊：\u003C/strong>室温（10-25°C）避湿储存，避免阳光直射，勿放卫生间等潮湿环境。\u003Cbr>\n          正确做法：药品外包装保留至疗程结束，方便随时查询生产批次与有效期。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>散剂、混悬剂：\u003C/strong>开启后需密闭防潮，用后按时密封，不可放在儿童容易接触的地方。\n        \u003C/li>\n      \u003C/ul>\n      过期药严禁随意丢弃，可送回医院药房或按照当地药品回收流程妥善处理。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">09 漏服及用量过多时的处理办法 🚨\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>口服片剂漏服：\u003C/strong>如漏服，想起时补服一次即可，不要为赶剂量而两次服用。\u003C/li>\n        \u003Cli>\n          \u003Cstrong>注射液：\u003C/strong>需在医院完成，若因特殊情况中断，请及时与医生联系，勿自行在家“补针”。\u003C/li>\n        \u003Cli>\n          \u003Cstrong>过量误服：\u003C/strong>出现明显副作用（如恶心、呕吐、皮肤灼热等）应第一时间就医，不要自行催吐或用民间偏方处理。\u003C/li>\n      \u003C/ul>\n      临床参考：有位患者自行加倍口服药量，导致手足肿胀加重，最终调整剂量后症状缓解。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">10 用药全程自我监测要点 👀\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>记录用药日期及用量：\u003C/strong>每日勾选/记录，避免重复及漏服。\u003C/li>\n        \u003Cli>\n          \u003Cstrong>监测不适症状：\u003C/strong>出现新发皮疹、恶心、听力下降、手脚麻木等要及时与医生沟通。\u003C/li>\n        \u003Cli>\n          \u003Cstrong>定期体检：\u003C/strong>依照医嘱复查肝肾功能、电解质及血常规。\u003C/li>\n        \u003Cli>\n          \u003Cstrong>家庭安全：\u003C/strong>药品远离儿童和宠物，不与其他家庭常用药混放。\u003C/li>\n      \u003C/ul>\n      正确做法：与家人或看护人共同参与管理，能有效减少用药相关风险。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drug-section\">\n    \u003Cdiv class=\"drug-section-bg\">\n      \u003Ch2 class=\"drug-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">关键参考文献 🔖\u003C/h2>\n    \u003C/div>\n    \u003Cdiv class=\"drug-section-content\">\n      \u003Col class=\"reference-list\">\n        \u003Cli id=\"ref1\">Cohen, S. M., & Lippard, S. J. (2001). Cisplatin: from DNA damage to cancer chemotherapy. \u003Ci>Progress in Nucleic Acid Research and Molecular Biology\u003C/i>, 67, 93–130.\u003C/li>\n        \u003Cli id=\"ref2\">Oostendorp, L. J. M., Stalmeier, P. F. M., van der Graaf, W. T. A., & Kruitwagen, R. F. P. M. (2011). Progression-free survival as a surrogate for overall survival in patients with advanced ovarian cancer. \u003Ci>European Journal of Cancer\u003C/i>, 47(6), 944–951.\u003C/li>\n        \u003Cli id=\"ref3\">Siegel, R. L., & Miller, K. D. (2017). Cancer Statistics, 2017. \u003Ci>CA: A Cancer Journal for Clinicians\u003C/i>, 67(1), 7–30.\u003C/li>\u003C/ol>\u003C/div>\u003C/section>\n\u003C/div>\n\n\u003Cstyle>\n.drug-guide-wrapper {\n  background: #f8f9fa;\n  font-family: \"Helvetica Neue\", Helvetica, Arial, \"PingFang SC\", \"Microsoft Yahei\", sans-serif;\n  max-width: 820px;\n  margin: 0 auto;\n  padding: 30px 18px 40px 18px;\n  border-radius: 10px;\n  box-shadow: 0 2px 12px rgba(175,175,205,0.13);\n}\n.drug-guide-title {\n  text-align: center;\n  font-size: 2.2em;\n  font-weight: bold;\n  color: #23415c;\n  margin-bottom: 30px;\n  letter-spacing: 1px;\n}\n.drug-section {\n  margin-bottom: 40px;\n}\n.drug-section-bg {\n  width: 100%;\n  min-height: 44px;\n  background: linear-gradient(100deg, #f3f7fa 70%, #eaeff3 100%);\n  border-radius: 8px 8px 0 0;\n  display: flex;\n  align-items: center;\n  padding: 0 13px 0 16px;\n  background-repeat: no-repeat;\n  background-size: cover;\n}\n.drug-section-title {\n  color: #256181;\n  font-size: 1.25em;\n  font-weight: 600;\n  letter-spacing: 1px;\n  padding: 7px 0;\n  margin: 0;\n  text-shadow: 0px 2px 4px rgba(233,244,251,0.11);\n}\n.drug-section-content {\n  background: #fff;\n  border-radius: 0 0 8px 8px;\n  padding: 18px 18px 16px 22px;\n  font-size: 1.09em;\n  color: #2a2a22;\n  line-height: 1.86em;\n  border: 1px solid #e2e8ef;\n  border-top: none;\n  min-height: 58px;\n  letter-spacing: 0.02em;\n}\n.drug-section-content ul {\n  padding-left: 21px;\n  margin-bottom: 12px;\n}\n.drug-section-content li {\n  margin-bottom: 8px;\n  line-height: 1.7em;\n}\n.drug-section-content strong {\n  color: #175fa8;\n}\n.drug-section-content em {\n  color: #e2726b;\n  font-style: normal;\n  font-weight: 600;\n}\n.reference-list {\n  font-size: 0.99em;\n  padding-left: 18px;\n  color: #43506b;\n}\n.reference-list li {\n  margin-bottom: 8px;\n}\n@media (max-width: 600px) {\n  .drug-guide-wrapper { padding: 9px 4px; }\n  .drug-guide-title { font-size: 1.35em; padding-top: 12px;}\n  .drug-section-title {font-size: 1em;}\n  .drug-section-content {padding:10px;}\n}\n\u003C/style>\n\n","\u003Cdiv class=\"drug-guide-wrapper\">\n  \u003Ch2 id=\"material_title\" class=\"drug-guide-title\" style=\"color: rg",561,"2025-09-24 16:37:07","贲门癌, 放疗, 药品安全, 化疗药物, 药物副作用, 用药指导, 老年患者用药, 食物相互作用","本指南全面介绍贲门癌III期患者在放疗期间使用相关药品的安全要点，涵盖抗肿瘤药物、放疗增敏剂等的正确使用和监测，确保治疗效果。","2025-10-04 06:30:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]