[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$f6EQIQ5RQH5UVJRBDtWnlSIOSSYDVBFbVMZ1YOAS-Pys":8,"$fPanxJZb8j0P5v1erKj2RK91gA2rT7tO8Yc-pyxIQpzo":55,"$fXCsYOaeD2zoVooX-uRfXSX9oNPB0aw99eBjM2dMJ66Y":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},67109,867673,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//illId40OjsB6XixR2m4hsD83ha1mACkR.png","郑春雷","上海电力医院","肿瘤科","副主任医师",111,0,"深入了解胆管恶性肿瘤：关键知识点","","https://ystcdn.venuertc.com/venue/AI/3cb5b34a-ed9e-4117-b24d-66d6ab2a8c53.jpg","\u003Cdiv id=\"material_title\" class=\"km_cholangiocarcinoma-title\">\n  \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">深入了解胆管恶性肿瘤：关键知识点\u003C/h2>\n  \u003Cp class=\"km_cholangiocarcinoma-intro\">\n    有时候，一些健康问题靠表面症状很难察觉，胆管恶性肿瘤（胆管癌）就是这样。谁能想到，一个几毫米的胆管出了事，会让身体出现一连串小细节的变化？这个主题我们就用生活中的语言聊聊——哪些现象需要警觉，哪些习惯或因素和胆管癌相关，检查方式、治疗手段、日常管理怎么做会更靠谱，最后还有权威参考给保障。\n  \u003C/p>\n\u003C/div>\n\u003Cdiv class=\"km_cholangiocarcinoma-section\">\n  \u003Cdiv class=\"km_cholangiocarcinoma-subsection km_cc_subtitle01\">\n    \u003Cdiv class=\"km_cholangiocarcinoma-bg01\">\n      \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01 胆管恶性肿瘤（胆管癌）到底是什么？\u003C/h2>\n      \u003Cp>\n        简单来说，胆管癌是一种发生在胆管的恶性肿瘤。胆管像是一条把肝脏产出的胆汁运输到肠道的“小马路”，如果路上出现了堵塞（肿瘤），胆汁就流不通。它不是常见病，却很隐蔽，平时难以抓住蛛丝马迹，需要系统了解一些核心知识。\n      \u003C/p>\n      \u003Cp>\n        胆管癌的病理基础在于胆管里某一部分细胞发生异常增生，形成癌肿块。这些“异常细胞”不仅抢占空间，还可能侵入附近组织，影响胆汁的正常流动——胆汁就像厨房里的清洁工，负责把消化后的油脂带走。癌细胞入侵，就像突然堵住了水池下水道。\n      \u003C/p>\n      \u003Cp>\n        这里要提一句，胆管癌跟其他肝胆疾病不同，它位置特殊、症状也很容易被日常其他小毛病掩盖。所以，基本了解每个环节，是提高警觉的关键。\n      \u003C/p>\n      \u003Cspan class=\"km_cholangiocarcinoma-emoji\">🧠🔬\u003C/span>\n    \u003C/div>\n  \u003C/div>\n  \u003Cdiv class=\"km_cholangiocarcinoma-subsection km_cc_subtitle02\">\n    \u003Cdiv class=\"km_cholangiocarcinoma-bg02\">\n      \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02 胆管癌的预警信号：哪些症状值得警觉？\u003C/h2>\n      \u003Cul class=\"km_cholangiocarcinoma-list\">\n        \u003Cli>\n          \u003Cstrong>1. 皮肤和眼白发黄： \u003C/strong>\n          这类黄疸一般是胆汁流出受阻，肿瘤初期偶尔会“轻微发黄”，但如果持续加深，家人多半能一眼察觉。别以为黄疸就是肝炎，持续性黄疸是胆管癌常见信号。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>2. 腹部隐痛、右上腹不适：\u003C/strong>\n          开始可能不明显，简单似“胀气”或“胃胀”，但一个星期甚至更长时间都不缓解，就要注意了。持续疼痛或者有时带点放射到背部的感觉，是警示信号。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>3. 体重下降明显：\u003C/strong>\n          不是刻意减肥，只是每个月无缘无故瘦几公斤，应该重视，不妨记录体重变化。如果最近明显轻了、食欲下降，最好咨询医生。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>4. 小便颜色深、粪便颜色变浅：\u003C/strong>\n          看似小事，其实是胆汁流向出了问题。肿瘤影响胆管，就会让便色变淡，小便像浓茶一样。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>病例参考:\u003C/strong>\n          一位56岁的已婚女性，发现自己皮肤和眼白明显发黄，半年体重下降近5公斤。她还有反复腹部隐痛，最终在肿瘤科确诊胆管恶性肿瘤。这提醒我们，有类似持续性症状不要拖，及时检查才靠谱。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cspan class=\"km_cholangiocarcinoma-emoji\">🔎⚠️\u003C/span>\n    \u003C/div>\n  \u003C/div>\n  \u003Cdiv class=\"km_cholangiocarcinoma-subsection km_cc_subtitle03\">\n    \u003Cdiv class=\"km_cholangiocarcinoma-bg03\">\n      \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03 胆管癌的原因与风险因素有哪些？\u003C/h2>\n      \u003Cp>\n        胆管癌之所以难防，不仅仅在于症状不明显，更在于很多风险因素隐藏在我们的生活里。多个国际研究发现，以下因素和胆管癌密切相关 (\u003Ca href=\"#ref1\">Khan et al., 2022\u003C/a>)：\n      \u003C/p>\n      \u003Cul class=\"km_cholangiocarcinoma-list\">\n        \u003Cli>\n          \u003Cstrong>慢性胆管炎：\u003C/strong>常年胆管炎症让局部细胞反复受损和修复，容易发生异常增生，增加肿瘤风险。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>先天性胆管畸形：\u003C/strong>有些人胆管天生弯曲、扩张或囊肿，这类结构异常更容易引发细胞变化。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>肝吸虫等寄生虫感染：\u003C/strong>部分地区肝胆寄生虫高发，这些“小麻烦”长期刺激胆管，引起炎症，进而增加癌变风险。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>胆囊结石、胆管结石：\u003C/strong>结石反复摩擦胆管黏膜，也会带来危险。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>年龄因素：\u003C/strong>大多数胆管癌患者在50岁以上，年纪增加，细胞自我修复和更新能力下降，更容易出问题。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>某些遗传因素：\u003C/strong>家族里有肝胆系统肿瘤史，个人患病几率也会增高。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        医学界统计（见\u003Ca href=\"#ref2\">Banales et al., 2020\u003C/a>），胆管癌发病在全球所有肿瘤中的占比不到1％，但在部分高发地区已经成为排名前五的消化道肿瘤。这种分布，提醒我们不要因为“罕见”就掉以轻心。\n      \u003C/p>\n      \u003Cspan class=\"km_cholangiocarcinoma-emoji\">🚦🔁\u003C/span>\n    \u003C/div>\n  \u003C/div>\n  \u003Cdiv class=\"km_cholangiocarcinoma-subsection km_cc_subtitle04\">\n    \u003Cdiv class=\"km_cholangiocarcinoma-bg04\">\n      \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04 胆管癌的诊断方式有哪些？怎么有效检查？\u003C/h2>\n      \u003Cp>\n        出现上述症状，最关键的是及时做检查。胆管癌的诊断主要依靠影像学和组织活检（来源: \u003Ca href=\"#ref3\">Nehls et al., 2021\u003C/a>），这里按流程分解：\n      \u003C/p>\n      \u003Cul class=\"km_cholangiocarcinoma-list\">\n        \u003Cli>\n          \u003Cstrong>1. 影像检查：\u003C/strong>\n          包括CT（电脑断层扫描）、MRI（磁共振成像）、超声波等。这些检查像给“胆管马路”做全身拍照，寻找是否有堵塞或异常增生。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>2. 实验室检查：\u003C/strong>\n          血清肿瘤标志物（如CA19-9、CEA）的升高有参考价值，不过不是唯一依据。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>3. 组织活检：\u003C/strong>\n          专业医生通过内镜或穿刺获取少量组织，让病理专家在显微镜下判定是否癌变。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>4. 影像诊断报告：\u003C/strong>\n          临床常结合查看影像图片，由专业医生解读各项指标，得出综合诊断建议。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        顺带提一句——诊断过程可能让人有些紧张，其实早一步明确疾病类型，对后续治疗方案有很大帮助。大多数医院诊断流程完善，只需要按医师建议一步步检查即可。\n      \u003C/p>\n      \u003Cspan class=\"km_cholangiocarcinoma-emoji\">🧾🩺\u003C/span>\n    \u003C/div>\n  \u003C/div>\n  \u003Cdiv class=\"km_cholangiocarcinoma-subsection km_cc_subtitle05\">\n    \u003Cdiv class=\"km_cholangiocarcinoma-bg05\">\n      \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05 胆管癌的治疗方案与预后如何评估？\u003C/h2>\n      \u003Cp>\n        治疗方案要根据病情个体化选择。现在，主流方式包括手术、化疗、放疗三类。根据具体分期和身体状态（见\u003Ca href=\"#ref4\">Bridgewater et al., 2014\u003C/a>），医生会量身定制。\n      \u003C/p>\n      \u003Cul class=\"km_cholangiocarcinoma-list\">\n        \u003Cli>\n          \u003Cstrong>1. 手术治疗：\u003C/strong>\n          如果肿瘤位置合适、扩散不明显，医生往往推荐“切除手术”。手术可直接清除肿瘤，是首选方案，但并非所有患者都适合。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>2. 化疗与放疗：\u003C/strong>\n          化疗药物如奥沙利铂、雷替曲塞通过静脉或动脉注射（如第二部分案例），可以控制肿瘤生长，放射治疗则精准打击局部病灶。具体方案需结合肝脏功能、身体耐受力。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>3. 辅助治疗：\u003C/strong>\n          包括止吐、肝保护以及抗凝等措施（案例患者用谷胱甘肽、那屈肝素钙等），帮助减轻化疗副作用，提高生活质量。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>4. 护理和生活管理：\u003C/strong>\n          动脉穿刺后要平卧六小时，监测足背动脉，24小时出入量记录等细节，都是预防并发症的关键环节。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        预后如何？这个问题和病情分期密切相关。医学统计显示，位于肝门部（肝胆交界处）的肿瘤治愈率相对低，早期发现并治疗，预后明显优于晚期。只要坚持正规治疗和科学随访，许多患者都能稳定生活几年甚至更长时间。\n      \u003C/p>\n      \u003Cspan class=\"km_cholangiocarcinoma-emoji\">💊🛡️\u003C/span>\n    \u003C/div>\n  \u003C/div>\n  \u003Cdiv class=\"km_cholangiocarcinoma-subsection km_cc_subtitle06\">\n    \u003Cdiv class=\"km_cholangiocarcinoma-bg06\">\n      \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06 胆管癌患者怎么科学管理日常生活？\u003C/h2>\n      \u003Cul class=\"km_cholangiocarcinoma-list\">\n        \u003Cli>\n          \u003Cspan class=\"km_cholangiocarcinoma-emoji\">🥗\u003C/span>\n          \u003Cstrong>饮食建议：\u003C/strong>优选高蛋白、富含新鲜蔬果和全谷类的餐食，有助于维持营养和肝功能。例如：鸡蛋、白肉（鸡胸肉、鱼类）、燕麦、小米，推荐蒸煮为主、清淡调味，每餐多加一些绿叶菜。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"km_cholangiocarcinoma-emoji\">🚶‍♂️\u003C/span>\n          \u003Cstrong>适度运动：\u003C/strong>根据体力状况，轻度步行、伸展操可以帮助提升体能和免疫力。不建议剧烈运动，以免加重症状。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"km_cholangiocarcinoma-emoji\">📅\u003C/span>\n          \u003Cstrong>定期复查：\u003C/strong>完成每轮治疗后，按时做影像和功能检查，目的是监测肿瘤变化、早发现新问题。家庭中可准备体温计、简易血压计作为辅助。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"km_cholangiocarcinoma-emoji\">👩‍⚕️\u003C/span>\n          \u003Cstrong>严格遵医嘱：\u003C/strong>所有用药（包括支持性药物和护理措施），需与肿瘤科或消化科专科医生沟通，不要擅自增减。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        其实，胆管癌的管理不仅靠医院，家人的支持、合理的作息安排和心理疏导也很重要。改善睡眠、保持好心情，对提升生活质量很有益处。如果遇到治疗相关的问题，可以直接向医生或护理团队反馈。\n      \u003C/p>\n      \u003Cspan class=\"km_cholangiocarcinoma-emoji\">💪🌱\u003C/span>\n    \u003C/div>\n  \u003C/div>\n  \u003Cdiv class=\"km_cholangiocarcinoma-subsection km_cc_subtitle07\">\n    \u003Cdiv class=\"km_cholangiocarcinoma-bg07\">\n      \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07 日常预防与健康行动建议\u003C/h2>\n      \u003Cp>\n        胆管癌虽不是常见病，日常防护却很有意义。想远离这个问题，比起恐惧，更推荐正面行动。下面这些举措值得尝试👇\n      \u003C/p>\n      \u003Cul class=\"km_cholangiocarcinoma-list\">\n        \u003Cli>\n          \u003Cstrong>1. 日常体检：\u003C/strong>40岁以后，尤其有肝胆家族史的朋友，坚持每两年查肝胆超声、常规化验，早发现细微变动更有保障。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>2. 饮食防护：\u003C/strong>多选新鲜蔬菜（西兰花、菠菜、番茄）、优质蛋白（鸡蛋、鸡肉、鱼肉），适度补充全谷类，有助于肝胆健康。可以每天变换种类，饭菜搭配多样化。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>3. 规律作息：\u003C/strong>保证每天7-8小时规律睡眠，减少熬夜，保持情绪稳定，对免疫系统有积极影响，间接帮助胆管修复。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>4. 选择正规医疗机构：\u003C/strong>遇到身体持续性不适，建议优先选择综合性三甲医院肿瘤科或消化科，就诊路径更专业。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>5. 避免过度心理压力：\u003C/strong>有疑问时及时咨询，不给自己过度焦虑的空间。不必担忧“万一是肿瘤”，先查明原因更可靠。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        说起来，健康管理是一种长期习惯，不是靠一时狠心“戒掉某个食物”能彻底解决。多些关注肝胆系统，遇到异常早点行动，往往就是对自己最好的保护。\n      \u003C/p>\n      \u003Cspan class=\"km_cholangiocarcinoma-emoji\">🌞📝\u003C/span>\n    \u003C/div>\n  \u003C/div>\n\u003C/div>\n\u003Cdiv class=\"km_cholangiocarcinoma-section\">\n  \u003Cdiv class=\"km_cholangiocarcinoma-references\" id=\"material_references\">\n    \u003Ch3 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">主要参考文献（APA格式）\u003C/h3>\n    \u003Cul>\n      \u003Cli id=\"ref1\">\u003Cspan class=\"km_cholangiocarcinoma-emoji\">📚\u003C/span> Khan, S. A., Tavolari, S., & Brandi, G. (2022). Cholangiocarcinoma: Epidemiology and risk factors. \u003Ci>Best Practice & Research Clinical Gastroenterology\u003C/i>, 56–57, 101768.\u003C/li>\n      \u003Cli id=\"ref2\">\u003Cspan class=\"km_cholangiocarcinoma-emoji\">📚\u003C/span> Banales, J. M., Marin, J. J., Lamarca, A., et al. (2020). Cholangiocarcinoma 2020: The next horizon in mechanisms and management. \u003Ci>Nature Reviews Gastroenterology & Hepatology\u003C/i>, 17(9), 557–588.\u003C/li>\n      \u003Cli id=\"ref3\">\u003Cspan class=\"km_cholangiocarcinoma-emoji\">📚\u003C/span> Nehls, O., Oussalah, A., Haas, C., et al. (2021). Diagnostic and prognostic biomarkers for cholangiocarcinoma. \u003Ci>International Journal of Molecular Sciences\u003C/i>, 22(12), 6502.\u003C/li>\n      \u003Cli id=\"ref4\">\u003Cspan class=\"km_cholangiocarcinoma-emoji\">📚\u003C/span> Bridgewater, J., Galle, P. R., Khan, S. A., et al. (2014). Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. \u003Ci>Journal of Hepatology\u003C/i>, 60(6), 1268–1289.\u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\u003C/div>\n\u003Cstyle>\n/* 独立风格名,避免全局污染 */\n.km_cholangiocarcinoma-title {\n  padding: 32px 16px 16px 16px;\n  background: linear-gradient(90deg, #f0fcfa 0%, #e4f7fa 100%);\n  border-radius: 16px 16px 0 0;\n  margin-top: 32px;\n}\n\n.km_cholangiocarcinoma-intro {\n  color: #325752;\n  font-size: 19px;\n  margin: 18px 0 0 0;\n  font-family: \"PingFang SC\", Arial, Helvetica, sans-serif;\n  line-height: 1.55em;\n}\n\n.km_cholangiocarcinoma-section {\n  padding: 0 14px;\n  max-width: 920px;\n  margin: 0 auto;\n}\n\n.km_cholangiocarcinoma-subsection {\n  margin-top: 32px;\n  padding: 0;\n  border-radius: 18px;\n  box-sizing: border-box;\n}\n\n.km_cc_subtitle01 .km_cholangiocarcinoma-bg01 {\n  background: linear-gradient(90deg, #e4f5e9 0%, #f5fcf8 100%);\n  padding: 28px 16px 18px 32px;\n  border-radius: 18px;\n  box-shadow: 0 2px 7px 0 rgba(160,192,160,0.06);\n}\n\n.km_cc_subtitle02 .km_cholangiocarcinoma-bg02 {\n  background: linear-gradient(90deg, #f8f7e8 0%, #fffde4 100%);\n  padding: 28px 18px 18px 32px;\n  border-radius: 18px;\n  box-shadow: 0 2px 7px 0 rgba(160,160,128,0.08);\n}\n\n.km_cc_subtitle03 .km_cholangiocarcinoma-bg03 {\n  background: linear-gradient(90deg, #f4eded 0%, #fcf6f6 100%);\n  padding: 28px 16px 18px 32px;\n  border-radius: 18px;\n  box-shadow: 0 2px 7px 0 rgba(180,120,120,0.05);\n}\n\n.km_cc_subtitle04 .km_cholangiocarcinoma-bg04 {\n  background: linear-gradient(90deg, #e8eeec 0%, #e8f6ff 100%);\n  padding: 28px 16px 18px 32px;\n  border-radius: 18px;\n  box-shadow: 0 2px 7px 0 rgba(160,192,224,0.09);\n}\n\n.km_cc_subtitle05 .km_cholangiocarcinoma-bg05 {\n  background: linear-gradient(90deg, #f5effb 0%, #f7f6ff 100%);\n  padding: 28px 16px 18px 32px;\n  border-radius: 18px;\n  box-shadow: 0 2px 7px 0 rgba(160,144,224,0.07);\n}\n\n.km_cc_subtitle06 .km_cholangiocarcinoma-bg06 {\n  background: linear-gradient(90deg, #f1f8ee 0%, #eefcf8 100%);\n  padding: 28px 16px 16px 32px;\n  border-radius: 18px;\n  box-shadow: 0 2px 7px 0 rgba(120,180,160,0.06);\n}\n\n.km_cc_subtitle07 .km_cholangiocarcinoma-bg07 {\n  background: linear-gradient(90deg, #fefaf8 0%, #fcf8f2 100%);\n  padding: 28px 16px 18px 32px;\n  border-radius: 18px;\n  box-shadow: 0 2px 8px 0 rgba(240,192,128,0.05);\n}\n\n.km_cholangiocarcinoma-list {\n  margin: 18px 0 0 0;\n  padding: 0 0 0 18px;\n  font-size: 17px;\n  line-height: 1.7em;\n  color: #484a52;\n  font-family: \"PingFang SC\", Arial, Helvetica, sans-serif;\n}\n\n.km_cholangiocarcinoma-list li {\n  margin-bottom: 12px;\n  font-size: 17px;\n}\n\n.km_cholangiocarcinoma-emoji {\n  font-size: 22px;\n  vertical-align: middle;\n  margin: 0 6px 0 0;\n}\n\n.km_cholangiocarcinoma-references {\n  margin-top: 40px;\n  margin-bottom: 40px;\n  padding: 24px;\n  background: linear-gradient(90deg, #f4fafb 0%, #e7f3fa 100%);\n  border-radius: 15px;\n  box-shadow: 0 2px 7px 0 rgba(120,200,220,0.07);\n}\n\n.km_cholangiocarcinoma-references h3 {\n  font-weight: bold;\n  font-size: 21px;\n  color: #23778e;\n  margin-bottom: 16px;\n}\n\n.km_cholangiocarcinoma-references ul {\n  padding-left: 22px;\n}\n\n.km_cholangiocarcinoma-references ul li {\n  margin-bottom: 11px;\n  font-size: 17px;\n  color: #476666;\n  line-height: 1.6em;\n}\n\u003C/style>\n","\u003Cdiv id=\"material_title\" class=\"km_cholangiocarcinoma-title\">\n  \u003Ch2 style=\"color: rgb(44, 62, 80); 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