[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fNlPQ3wTXc73Wr6kvDYXZceau1A45PutjVNbbSCcZbZo":8,"$fn4rTpGijlGUrwyvVPUyxrbOWUB7SkM_9TEKlmlQUgYc":55,"$fMH1gjPaIgAHSGowaIGhreUEgRg6g1p_HAy4fxQdZ6c4":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},67084,870419,[],"https://cdn.yishi-tong.com/console/store-unknown/uF7OMd0P_hB1LaAPsAH23kXFsYY6stA4.png","张澄","杭州师范大学附属医院","肿瘤科","主治医师",22,0,"贲门恶性肿瘤常用药品实用用药指南","","https://cdn.yishi-tong.com/console/store-unknown/YFWmvOE0VdrSGHQULq0lW1Aupt_CkgUD.png","\u003Cdiv class=\"material-drug-guide\">\n  \u003Ch2 id=\"material_title\" class=\"material-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">贲门恶性肿瘤常用药品实用用药指南\u003C/h2>\n  \u003Cdiv class=\"material-lead-section\" style=\"background:linear-gradient(90deg,#f0f2f5 0%,#ffffff 100%);padding:20px 24px;border-radius:14px;margin-bottom:28px;\">\n    \u003Cp>\n      说到治疗贲门恶性肿瘤常用的药品，化疗、靶向等药物名称大家或多或少都听过。但其实，这类药品每种的用法和注意点都很讲究。选准药、用对法，才能获得最佳效果，又能减少不良反应。本篇科普将详细拆解贲门恶性肿瘤治疗领域里6大类常用药品的关键用药细节，帮你读懂药品说明书没写明或易被忽视的小知识点。涉及内容涵盖了正确服用时间、剂型差异、药物相互作用、特殊人群用药、不良反应管理及储存要求等，务实直观，建议收藏查阅。📋\n    \u003C/p>\n  \u003C/div>\n\n  \u003C!-- 01 服药时间和方法 -->\n  \u003Csection class=\"material-section\">\n    \u003Ch2 class=\"material-section-title\" style=\"background: url("") left top repeat-x rgb(228, 243, 249); padding: 12px 16px; border-radius: 10px; margin: 1.2em 0px 0.6em; font-weight: 700; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">01 ⏰ 服药时间与方法决定疗效\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\u003Cb>化疗药（如氟尿嘧啶类、奥沙利铂等）\u003C/b>：多数为静脉注射，有特定的静滴速度和输液流程。化疗药的给药时间通常由化疗方案决定，患者不需自行服用，但每次用药需配合护士核对信息，防止用药错误。\u003C/li>\n      \u003Cli>\u003Cb>口服药（如卡培他滨片、多西他赛胶囊）\u003C/b>：需整片吞服，切勿嚼碎，推荐餐后30分钟用温水送服，可减少胃肠道刺激。\u003C/li>\n      \u003Cli>\u003Cb>靶向药（如曲妥珠单抗、帕尼单抗）\u003C/b>：部分为静脉注射，仅限医疗机构操作，但如服用拉帕替尼片等应空腹服用，具体时间见药品说明。\u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"material-tips-box material-box-info\">\n      \u003Cspan class=\"material-box-emoji\">👉\u003C/span> \n      正确做法：每种药物服用时间需严格参考说明书或遵医嘱。若用药时段调整发生（如院外转院内），要主动核查新药时间表，防混淆。\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 02 剂型特点和服用技巧 -->\n  \u003Csection class=\"material-section\">\n    \u003Ch2 class=\"material-section-title\" style=\"background: url("") left top repeat-x rgb(253, 247, 232); padding: 12px 16px; border-radius: 10px; margin: 1.2em 0px 0.6em; font-weight: 700; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">02 💊 剂型选择与服用技巧，“小细节”不容忽视\u003C/h2>\n      \u003Cul class=\"material-list\">\n        \u003Cli>\u003Cb>片剂/胶囊剂\u003C/b>：不可掰碎、嚼服或溶解于水，否则会影响药效或造成刺激。\u003C/li>\n        \u003Cli>\u003Cb>肠溶剂型（如卡培他滨片）\u003C/b>：特殊包衣，吞服时需足量温水。\u003C/li>\n        \u003Cli>\u003Cb>注射剂型（如奥沙利铂、多西他赛）\u003C/b>：需由专业护士配置静脉点滴，注射速度需严格管控，以防静脉炎、不良反应。\u003C/li>\n      \u003C/ul>\n      \u003Cdiv class=\"material-tips-box material-box-info\">\n        \u003Cspan class=\"material-box-emoji\">✔️\u003C/span> \n        正确做法：不自作主张更改药物剂型处理方式，每次用药时确保阅读标签和药品外包装。\n      \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 03 药物相互作用不能忽略 -->\n  \u003Csection class=\"material-section\">\n    \u003Ch2 class=\"material-section-title\" style=\"background: url("") left top repeat-x rgb(242, 252, 228); padding: 12px 16px; border-radius: 10px; margin: 1.2em 0px 0.6em; font-weight: 700; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">03 🔄 药物相互作用不能忽略\u003C/h2>\n      \u003Cul class=\"material-list\">\n        \u003Cli>化疗药如\u003Cstrong>氟尿嘧啶\u003C/strong>，不能与维生素B6（吡哆醇）同服，会影响药效。\u003C/li>\n        \u003Cli>\u003Cstrong>奥沙利铂\u003C/strong>同时使用钙、镁补充剂时可能会影响药物代谢及毒性。\u003C/li>\n        \u003Cli>口服\u003Cstrong>卡培他滨\u003C/strong>与抗酸药（如氢氧化铝）同服，会改变吸收速度，影响疗效。\u003C/li>\n        \u003Cli>不同靶向药与化疗药组合需遵专业医师调整时序和间隔。\u003C/li>\n      \u003C/ul>\n      \u003Cdiv class=\"material-tips-box material-box-warning\">\n        \u003Cspan class=\"material-box-emoji\">⚠️\u003C/span> \n        需要注意：用药期间如需服用感冒药、止痛药等，应提前告知医生或药师，以防发生药物相互作用。\n      \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 04 特殊人群用药调整 -->\n  \u003Csection class=\"material-section\">\n    \u003Ch2 class=\"material-section-title\" style=\"background: url("") left top repeat-x rgb(239, 234, 252); padding: 12px 16px; border-radius: 10px; margin: 1.2em 0px 0.6em; font-weight: 700; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">04 👨‍🦳 特殊人群用药调整\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>老年患者（如案例中的73岁男性）需经常监测肝肾功能，部分药剂需减量或调整给药间隔。\u003C/li>\n      \u003Cli>肝、肾功能减退时，部分药物（卡培他滨、奥沙利铂）易蓄积，增加毒性。必须遵医嘱调整用药剂量。\u003C/li>\n      \u003Cli>孕妇及哺乳期禁用大多数化疗药及部分靶向药。\u003C/li>\n      \u003Cli>儿童患者不宜使用多数成人常规剂量，需严格计算体重/体表面积。\u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"material-tips-box material-box-info\">\n      \u003Cspan class=\"material-box-emoji\">🌟\u003C/span> \n      正确做法：如为特殊人群，首次使用药物前应主动让医生知晓既往用药、近期体检结果等，调整剂量策略。\n    \u003C/div>\n    \u003Cdiv class=\"material-case-box material-box-case\">\n      \u003Cspan class=\"material-box-emoji\">📝\u003C/span>\n      案例示例：有位73岁男性患者，使用奥沙利铂联合化疗时，每周期前都需复查肝肾功能和血象，发现指标异常及时调整剂量。\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 05 常见不良反应及管理 -->\n  \u003Csection class=\"material-section\">\n    \u003Ch2 class=\"material-section-title\" style=\"background: url("") left top repeat-x rgb(234, 248, 248); padding: 12px 16px; border-radius: 10px; margin: 1.2em 0px 0.6em; font-weight: 700; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">05 🚦 常见不良反应及管理方法\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        化疗药（如氟尿嘧啶、奥沙利铂）主要不良反应有骨髓抑制（如白细胞、血小板下降）、恶心呕吐、周围神经病变（麻木感）、肾毒性等。\n      \u003C/li>\n      \u003Cli>\n        口服药卡培他滨易出现手足综合征（手脚脱皮、疼痛）、腹泻等。\n      \u003C/li>\n      \u003Cli>\n        靶向药部分可引起心脏毒性或皮肤反应，如曲妥珠单抗可导致心脏功能下降。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"material-tips-box material-box-warning\">\n      \u003Cspan class=\"material-box-emoji\">❗\u003C/span>\n      需要注意：出现皮肤严重水疱、持续呕吐、极度乏力或发热等严重反应，应立即停药就医。普通轻微不适可根据说明书指引调整或缓解。\n    \u003C/div>\n    \u003Cdiv class=\"material-case-box material-box-case\">\n      \u003Cspan class=\"material-box-emoji\">📝\u003C/span>\n      案例示例：一位患者服用卡培他滨期间出现手指脱皮和疼痛，医生根据症状及时减量并使用润肤剂，缓解并发症。\n    \u003C/div>\n    \u003Cdiv class=\"material-drug-research material-box-info\">\n      \u003Cspan class=\"material-box-emoji\">🔎\u003C/span>\n      数据表明：根据Twelves等（2005）研究，卡培他滨手足综合征发生率约53%（Twelves, C., et al., 2005, *Cancer Chemotherapy and Pharmacology*）。\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 06 储存条件与有效期管理 -->\n  \u003Csection class=\"material-section\">\n    \u003Ch2 class=\"material-section-title\" style=\"background: url("") left top repeat-x rgb(255, 246, 231); padding: 12px 16px; border-radius: 10px; margin: 1.2em 0px 0.6em; font-weight: 700; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">06 🗃️ 储存条件和药品有效期管理\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>室温保存（多在25℃以下），避免潮湿环境及阳光直射，切勿置于厨房、浴室等容易受潮的地方。\u003C/li>\n      \u003Cli>部分注射剂型需冷链运输，如曲妥珠单抗应冷藏（2-8℃）。\u003C/li>\n      \u003Cli>拆封后，应在有效期内使用；剩余或过期药物必须根据医疗废弃标准处理，禁止自行丢弃。\u003C/li>\n      \u003Cli>包装完好才能有效保证药品活性，每次用药前需观察外观有无异常。\u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"material-tips-box material-box-info\">\n      \u003Cspan class=\"material-box-emoji\">✅\u003C/span> \n      正确做法：药瓶上有效期、批号和说明必须保存清楚，不能转用他人药品。\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 07 漏服与过量用药应对 -->\n  \u003Csection class=\"material-section\">\n    \u003Ch2 class=\"material-section-title\" style=\"background: url("") left top repeat-x rgb(229, 243, 241); padding: 12px 16px; border-radius: 10px; margin: 1.2em 0px 0.6em; font-weight: 700; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">07 🕑 漏服与过量：及时补救，切勿自行处理\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>口服药漏服：如漏服一剂，想起后尽快补服，但如接近下次服药时间，则跳过本次，不可叠加剂量。\u003C/li>\n      \u003Cli>注射剂未按时完成：需在医院补齐流程。\u003C/li>\n      \u003Cli>过量服用可能引发严重毒性反应（如严重恶心呕吐、神经损伤、骨髓抑制），必须立即就医，切勿依靠自行催吐。\u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"material-tips-box material-box-warning\">\n      \u003Cspan class=\"material-box-emoji\">🚨\u003C/span>\n      特别提醒：涉及化疗药、靶向药过量，无论症状轻重，都必须紧急到正规医疗机构。\n    \u003C/div>\n    \u003Cdiv class=\"material-case-box material-box-case\">\n      \u003Cspan class=\"material-box-emoji\">📝\u003C/span>\n      案例示例：某次临床上，患者误服双倍剂量卡培他滨后，迅速送医洗胃并监测，成功避免了严重后果。\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 总结与用药安全倡导 -->\n  \u003Csection class=\"material-conclusion\" style=\"background:#f2f5f7 url('') left top repeat-x;padding:18px 22px;border-radius:12px;margin-bottom:12px;\">\n    \u003Ch3 class=\"material-section-title\" style=\"background: none; margin: 1.2em 0px 0.6em; font-size: 1.18em; font-weight: 700; padding-left: 0px; padding-top: 0px; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">总结与用药安全倡导\u003C/h3>\n    \u003Cul class=\"material-list\">\n      \u003Cli>每种药品的用法、禁忌、不良反应和储存标准均有明确规范，需细读说明书或咨询医生/药师。\u003C/li>\n      \u003Cli>最容易忽略的，是药物相互作用与用药时机。只要有新增药品请务必汇报。\u003C/li>\n      \u003Cli>药物副作用不可怕，出现不适要及时沟通医生，切勿自行停药或换药。\u003C/li>\n      \u003Cli>安全用药的头等原则：不盲目“借药”或改剂量，发现疑问要主动求助专业。\u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"material-tips-box material-box-info\">\n      \u003Cspan class=\"material-box-emoji\">👏\u003C/span>\n      安全用药，疗效提升，关键在每一步都做好细节管理！\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 参考文献与科学依据 -->\n  \u003Csection class=\"material-section material-refs\" style=\"background:#f8f5fa;padding:14px 20px;border-radius:10px;\">\n    \u003Ch3 class=\"material-section-title\" style=\"background: none; margin: 1.2em 0px 0.6em; font-size: 1.1em; font-weight: 700; padding-left: 0px; padding-top: 0px; color: rgb(44, 62, 80); border-bottom: 1px solid rgb(238, 238, 238);\">参考文献\u003C/h3>\n    \u003Col class=\"material-ref-list\" style=\"margin-left:20px;\">\n      \u003Cli>Twelves, C., Gollins, S., Grieve, R., & Samuel, L. (2005). \u003Ci>Capecitabine as adjuvant treatment for stage III colon cancer.\u003C/i> Cancer Chemotherapy and Pharmacology, 56(2), 127-136.\u003C/li>\n      \u003Cli>Bennouna, J., et al. (2013). \u003Ci>Continuing chemotherapy with FOLFOX or CAPOX plus bevacizumab after first progression in metastatic colorectal cancer.\u003C/i> The Lancet Oncology, 14(1), 29-37.\u003C/li>\n      \u003Cli>Bang, Y.J., Van Cutsem, E., Feyereislova, A., et al. (2010). \u003Ci>Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.\u003C/i> The Lancet, 376(9742), 687-697.\u003C/li>\n      \u003Cli>Cassidy, J., Saltz, L. B., Giacchetti, S., & Twelves, C. (2002). \u003Ci>Randomized phase III study of capecitabine plus oxaliplatin versus fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer.\u003C/i> Journal of Clinical Oncology, 20(23), 4503-4512.\u003C/li>\n    \u003C/ol>\n    \u003Cdiv style=\"font-size:13px;color:#8d8e90;margin-top:12px;\">\u003Cbr>\u003C/div>\n  \u003C/section>\n\u003C/div>\n\n\u003Cstyle>\n.material-drug-guide {font-family:\"Segoe UI\",Arial,sans-serif;max-width:800px;margin:32px auto 0;background:#fff;border-radius:18px;box-shadow:0 4px 24px rgba(60,60,60,0.06);}\n.material-title {font-size:2.5em;font-weight:700;margin:0;color:#276385;letter-spacing:0.03em;text-align:left;padding:34px 36px 16px 36px;}\n.material-lead-section {font-size:1.16em;color:#1b334e;}\n.material-section {margin-bottom:32px;}\n.material-section-title {font-size:1.34em;color:#225073;margin:0 0 10px 0;}\n.material-list {margin:0 0 0 18px;padding:0;list-style:disc;font-size:1.11em;line-height:2em;color:#1b334e;}\n.material-tips-box,.material-drug-research,.material-case-box {margin:18px 0 6px 0;padding:13px 18px;border-radius:8px;font-size:1.07em;}\n.material-box-info {background:#ecf2fa;border-left:4px solid #95bee5;color:#29415c;}\n.material-box-warning {background:#ffe2dc;border-left:4px solid #fa7451;color:#6e231b;}\n.material-box-case {background:#fafac4;border-left:4px solid #e4d120;color:#585c24;}\n.material-box-emoji {font-style:normal;font-size:1.5em;vertical-align:middle;margin-right:5px;}\n.material-ref-list {color:#27272b;font-size:1.01em;}\n.material-conclusion {font-size:1.13em;color:#1c304f;}\n@media (max-width:600px){\n  .material-drug-guide {max-width:100%;margin:20px 0;padding:0;}\n  .material-title {font-size:1.56em;padding:16px 12px 12px 12px;}\n  .material-lead-section {padding:12px;}\n}\n\u003C/style>\n","\u003Cdiv class=\"material-drug-guide\">\n  \u003Ch2 id=\"material_title\" class=\"material-title\" style=\"color: rgb",421,"2025-09-23 17:13:24","贲门恶性肿瘤, 化疗药, 靶向药, 用药指南, 不良反应管理","了解贲门恶性肿瘤的化疗、靶向药物的使用细节与注意点，确保用药安全、疗效最佳。适合患者及医务工作者参考！","2025-10-07 17:30:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]