[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fmV5788fki9j-KXbS2MJJKfhM9BymqMGpCd6-fMwQ1_w":8,"$fc3bjY3lNffU64hYyk3iO_VF5rakCq3GDNoPgEcQLv0w":55,"$fPMt6B-imIGiniauJWClHXRRrvq_6IPcDo31F1CsE6es":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},66612,869460,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//oxzyB6fWPWB6dtH5WvFkMh8jEI76jIwG.png","田彦华","树兰（杭州）医院","皮肤性病科","主治医师",35,0,"皮肤恶性黑色素瘤常用药品使用实用指南","","https://ystcdn.venuertc.com/venue/AI/3ef0b5b4-eb50-4949-a2e5-b11d5e435694.jpg","\u003Cdiv class=\"melanoma-guide-component\">\n  \u003Ch1 id=\"material_title\" class=\"melanoma-guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n    皮肤恶性黑色素瘤常用药品使用实用指南\n  \u003C/h1>\n  \n  \u003Csection class=\"melanoma-guide-section melanoma-guide-intro\">\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cp>\n        说起来，面对恶性黑色素瘤，药品选择和安全用药始终是大家最关心的事情。不管是化疗、靶向还是免疫药物，它们的使用方法、常见不良反应和相互作用等细节都会直接影响效果和安全。本文总结了七类核心要点，从用药时机、剂型选择到副作用处理，每一点都实用直接，适合日常参考。读完之后，你会知道“这个药要这样用”的关键要诀。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 01 剂型与服用技巧 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      01 剂型与服用技巧 🎯\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">化疗药品：\u003C/span>以静脉注射剂常见，如达卡巴嗪、顺铂、多柔比星。必须在医疗机构完成。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">靶向制剂：\u003C/span>多为片剂（口服），如达拉非尼、维莫非尼。需要整片吞服，忌咀嚼、掰开或磨碎，温水送服。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">免疫药物：\u003C/span>常用药如帕博利珠单抗、纳武利尤单抗，主要为静脉滴注方式，需在专业科室操作，单次输注时间通常30-120分钟。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">辅助药：\u003C/span>如止吐药昂丹司琼有片剂和注射液两类。片剂需整片吞服，注射液则按医嘱静脉推注。\n        \u003C/li>\n        \u003Cli>\n          服药时推荐用200-300ml温水送服，特别是口服片剂。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">案例：\u003C/span>临床中有患者因维莫非尼片剂咀嚼后服用，出现消化不良。正确做法应为整片吞服。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 02 药品作用机制简单说明 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      02 药品作用机制速览 🔬\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">化疗药：\u003C/span>如达卡巴嗪、顺铂等，通过干扰细胞分裂实现抗肿瘤效果。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">靶向治疗：\u003C/span>达拉非尼、恩可拉非尼、维莫非尼通过抑制BRAF基因突变相关酶的活性，仅作用于含特定突变的癌细胞。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">免疫治疗：\u003C/span>帕博利珠单抗、纳武利尤单抗为PD-1抑制剂，可解除肿瘤细胞对免疫系统的抑制，增强T细胞活性攻击肿瘤。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">辅助治疗：\u003C/span>如海曲泊帕属于促血小板生成剂，通过刺激骨髓以提升血小板水平，用于化疗后支持。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"melanoma-guide-minitext\">\n        这些机制直接决定了药品的适应症和常见副作用，但具体用法还需结合药品说明书。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 03 用药时机和用法用量 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      03 合理用药时机与正确用量 ⏰\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">化疗药品：\u003C/span>\n          采用周期方案，多数每21-28天为一疗程，由医生根据体表面积/病情调整具体用量。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">靶向药：\u003C/span>\n          推荐固定时段服药，如每天早晚各一次。饱腹或空腹服用需严格参考说明书，有些药需空腹，否则药效受影响。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">免疫疗法：\u003C/span>\n          注射间隔通常为2-3周。需要全程监测输液反应。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">辅助药品：\u003C/span>\n          如昂丹司琼片，多在化疗前30分钟至1小时服用，可有效预防急性恶心。\n        \u003C/li>\n        \u003Cli>\n          忘记服药时，发现时间未超24小时可补服，若超时则跳过，不可双倍用药。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">小贴士：\u003C/span>\n          用药时间可以设置手机提醒，防止漏服，提高依从性。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 04 药物相互作用与合理搭配 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      04 药物相互作用需警惕 ⚠️\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          靶向药品如达拉非尼、维莫非尼可与多种药物发生相互作用（如酶诱导剂、酶抑制剂），影响其血药浓度。\n        \u003C/li>\n        \u003Cli>\n          部分口服药不可与葡萄柚汁同服，会抑制或增强药效，带来额外风险。\n        \u003C/li>\n        \u003Cli>\n          化疗期间，避免与肝毒性或肾毒性药物（部分抗生素、非甾体类消炎药）同时用药，防止累加损伤。\n        \u003C/li>\n        \u003Cli>\n          昂丹司琼等止吐药与含5-羟色胺活性的药物合用，可能诱发5-HT综合征（表现为皮肤潮红、心悸等）。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">正确做法：\u003C/span>遇到新药加入或停止用药，务必咨询医生或药师，确认药物能否安全合用。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">案例：\u003C/span>曾有患者在靶向治疗期间擅自服用感冒药，导致药物浓度变化，效果减弱。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 05 特殊人群的用药方案 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      05 特殊人群用药细节 🧓🤰\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">老年患者：\u003C/span>肝肾代谢能力下降，部分药物（如达卡巴嗪）需要酌情降低剂量，定期做肝肾功能监测。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">肝肾功能不全：\u003C/span>部分靶向药、辅助药需要剂量个体化，具体调整请遵医嘱。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">孕妇：\u003C/span>多数化疗和靶向药禁止在妊娠期使用。必须评估风险与获益。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">儿童：\u003C/span>黑色素瘤相关药品在儿童中的适应症有限，用药需格外谨慎，按说明书体重调整。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">案例：\u003C/span>\n          一位65岁女性患者，化疗期间出现骨髓抑制，后调整剂量并加强支持，用药更平稳。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">正确做法：\u003C/span>特殊人群变化较大，遇以下情况需主动告知医生：既往药物过敏、慢性病、近期怀孕计划。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 06 常见不良反应及时处理 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      06 常见不良反应及应对方案 🩹\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">化疗药：\u003C/span>骨髓抑制（血细胞下降）、消化道反应、脱发。出现感染或贫血症状应及时联系医生。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">靶向药：\u003C/span>皮肤反应（红疹、瘙痒）、关节痛。皮肤异常可用温和保湿剂、避免刺激性外用药。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">免疫药：\u003C/span>输注反应（发热、低血压、皮疹），或免疫相关副反应（如甲状腺功能变化）。出现持续高热、皮疹、胰腺炎或呼吸困难等需立即就医。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">辅助药：\u003C/span>昂丹司琼可能引发便秘、少见心律失常，出现心悸应停药并报告医生。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">轻度反应处理：\u003C/span>如单纯轻度皮疹、轻度恶心，可适当调整生活方式，注意多饮水、饮食清淡。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">严重/持久不适：\u003C/span>任何无法缓解或加重的不良反应应停止相关药物，并第一时间就医。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"melanoma-guide-minitext\">\n        \u003Cspan class=\"melanoma-guide-strong\">数据参考：\u003C/span>PD-1类药物不良反应发生率约为10-30%，大多数可逆转（参考：Robert, C. et al., 2015）。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 07 储存与有效期管理 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      07 储存环境与有效期管理 📦\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">储存条件：\u003C/span>绝大多数口服和注射黑色素瘤相关药如靶向药、免疫药需避光、干燥保存，一般在25°C以下。部分特殊药物需冷藏（2-8°C），遵医嘱为准。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">开封要求：\u003C/span>片剂或胶囊类开瓶后紧密封好，防止受潮。多剂量针剂使用后应及时盖好瓶塞，避免污染。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">有效期：\u003C/span>按药品包装标识为准，逾期药品不可再用。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">过期药品处理：\u003C/span>不可随意丢弃，建议交还至药店或医疗机构统一回收，避免环境污染。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">正确做法：\u003C/span>每次用药前留意包装“生产”和“有效期”，有疑问时拍照记录，便于就诊时核对。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 08 使用体验与实践总结 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      08 实操经验总结与特别提醒 📝\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg\">\n      \u003Cul class=\"melanoma-guide-list\">\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">用药清单别混淆：\u003C/span>多药并用时，可用表格或APP将药名、剂量、服药时间记录清楚，防止遗漏或重复。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">复诊带药盒：\u003C/span>去医院随访/复查时，随身携带全部药品或说明书，便于医生药师判断用药合理性。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">及时沟通新反应：\u003C/span>如出现未在说明书标明的症状，或者用药后有持续不适，务必记录发生时间和具体表现，第一时间向医护人员咨询。\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"melanoma-guide-strong\">群体用药安全：\u003C/span>家庭成员如需协助投药，需一人专责，避免他人误服或自作主张调整用量。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp class=\"melanoma-guide-minitext\">\n        \u003Cspan class=\"melanoma-guide-strong\">核心提醒：\u003C/span>相同药品生产厂家、规格、剂型可能不同，使用时严格对照医嘱和包装信息。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 09 关键参考文献与出处 -->\n  \u003Csection class=\"melanoma-guide-section\">\n    \u003Ch2 class=\"melanoma-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\n      09 主要文献与进一步阅读 🔖\n    \u003C/h2>\n    \u003Cdiv class=\"melanoma-guide-bg melanoma-guide-reference\">\n      \u003Col>\n        \u003Cli>\n          Robert, C., Schachter, J., Long, G. V., et al. (2015). Pembrolizumab versus Ipilimumab in Advanced Melanoma. \u003Cspan class=\"melanoma-guide-ita\">The New England Journal of Medicine\u003C/span>, 372(26), 2521–2532. \u003Ca href=\"https://pubmed.ncbi.nlm.nih.gov/25891173/\" target=\"_blank\" rel=\"noopener\">PubMed\u003C/a>\n        \u003C/li>\n        \u003Cli>\n          Flaherty, K. T., Infante, J. R., Daud, A., et al. (2012). Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations. \u003Cspan class=\"melanoma-guide-ita\">The New England Journal of Medicine\u003C/span>, 367(18), 1694–1703. \u003Ca href=\"https://pubmed.ncbi.nlm.nih.gov/23020132/\" target=\"_blank\" rel=\"noopener\">PubMed\u003C/a>\n        \u003C/li>\n        \u003Cli>\n          Merck Manual - Consumer Version: Melanoma. Vinod E. Nambudiri, MD, MBA, EdM, 2024. \u003Ca href=\"https://www.msdmanuals.com/en-cn/home/skin-disorders/malignant-melanoma/melanoma\" target=\"_blank\" rel=\"noopener\">View\u003C/a>\n        \u003C/li>\n        \u003Cli>\n          Eigentler, T. K., Caroli, U. M., Radny, P., & Garbe, C. (2011). Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomized clinical trials. \u003Cspan class=\"melanoma-guide-ita\">The Lancet Oncology\u003C/span>, 12(8), 816–824. \u003Ca href=\"https://pubmed.ncbi.nlm.nih.gov/21798636/\" target=\"_blank\" rel=\"noopener\">PubMed\u003C/a>\n        \u003C/li>\n        \u003Cli>\n          Long, G. V., Stroyakovskiy, D., Gogas, H., et al. (2015). Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial. \u003Cspan class=\"melanoma-guide-ita\">The Lancet\u003C/span>, 386(9992), 444–451. \u003Ca href=\"https://pubmed.ncbi.nlm.nih.gov/26037941/\" target=\"_blank\" rel=\"noopener\">PubMed\u003C/a>\n        \u003C/li>\n      \u003C/ol>\n      \u003Cp class=\"melanoma-guide-minitext\">\n        以上文献可通过PubMed、MSD手册等权威医学数据库检索获取，为本指南提供数据和药品信息支持。\u003C/p>\u003C/div>\u003C/section>\n\u003C/div>\n\n\u003Cstyle>\n.melanoma-guide-component {\n  font-family: \"Segoe UI\", \"Helvetica Neue\", Arial, \"PingFang SC\", \"Hiragino Sans GB\", \"Microsoft YaHei\", sans-serif;\n  max-width: 820px;\n  margin: 0 auto;\n  background: #FAFAFA;\n  color: #232323;\n  border-radius: 10px;\n  box-shadow: 0 6px 24px rgba(50,50,60,0.08);\n  padding: 0;\n}\n.melanoma-guide-title {\n  background: linear-gradient(90deg, #f3e7e9 0%, #e3eee0 100%);\n  padding: 38px 20px 22px 30px;\n  border-radius: 10px 10px 0 0;\n  font-size: 2.1rem;\n  text-align: left;\n  font-weight: 700;\n  margin-bottom: 20px;\n  letter-spacing: 1px;\n}\n.melanoma-guide-section {\n  margin-bottom: 34px;\n  padding: 0 24px;\n}\n.melanoma-guide-bg {\n  background: linear-gradient(100deg, #fcfcfc 80%, #e1ecee 100%);\n  border-radius: 8px;\n  padding: 22px 22px 17px 22px;\n  min-height: 54px;\n  margin-top: 7px;\n  box-shadow: 0 2px 6px rgba(200,220,220,0.05);\n}\n.melanoma-guide-subtitle {\n  background: linear-gradient(20deg, #daece5 75%, #fcf2f5 100%);\n  font-size: 1.35rem;\n  padding: 9px 13px 10px 18px;\n  border-radius: 8px 8px 0 0;\n  margin: 0 0 4px 0;\n  font-weight: bold;\n  letter-spacing: 0.5px;\n  box-shadow: 0 2px 6px rgba(140,210,210,0.04);\n}\n.melanoma-guide-list {\n  padding-left: 18px;\n  font-size: 1.04rem;\n  margin-bottom: 0;\n  color: #2C3D37;\n}\n.melanoma-guide-list li {\n  margin-bottom: 12px;\n  list-style-type: disc;\n  line-height: 1.9;\n}\n.melanoma-guide-strong {\n  font-weight: bold;\n  color: #286A5F;\n}\n.melanoma-guide-minitext {\n  font-size: 0.97rem;\n  margin-top: 16px;\n  color: #626262;\n  letter-spacing: 0.1em;\n}\n.melanoma-guide-ita {\n  font-style: italic;\n}\n.melanoma-guide-reference a {\n  color: #3366cc;\n  text-decoration: underline;\n}\n.melanoma-guide-reference a:hover {\n  color: #194d96;\n}\n.melanoma-guide-summary {\n  margin-bottom: 0;\n}\n.melanoma-guide-intro {\n  margin-bottom: 28px;\n}\n@media (max-width:650px) {\n  .melanoma-guide-component { max-width: 98%; padding: 0;}\n  .melanoma-guide-section { padding: 0 6px;}\n  .melanoma-guide-title { padding: 22px 7px 14px 10px; font-size: 1.35rem;}\n  .melanoma-guide-subtitle { font-size: 1.11rem; padding: 7px 8px 7px 9px;}\n  .melanoma-guide-bg { padding: 9px 6px 9px 9px; }\n}\n\u003C/style>\n","\u003Cdiv class=\"melanoma-guide-component\">\n  \u003Ch1 id=\"material_title\" class=\"melanoma-guide-title\" style=",525,"2025-09-17 13:53:30","恶性黑色素瘤, 化疗药, 靶向药, 免疫治疗药, 安全用药","本文为您提供了关于皮肤恶性黑色素瘤的药品使用指南，涵盖药物种类、用药时机及副作用处理等实用信息，帮助患者安全用药。","2025-09-27 12:30:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]