[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$f0TIMS1HaH9fy---PlkqCxxjFuehEusMbtsz2FmTRc7I":8,"$fWCeaiVeTk-iy9DKeeSNuCFBfuwMRySy6VrnFPDObwQ0":55,"$fRQClnmaRo3D48hM8qPt0e_40m0OfDjg_Dq6V1uozW4w":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},66601,867153,[],"https://cdn.yishi-tong.com/console/store-unknown/uF7OMd0P_hB1LaAPsAH23kXFsYY6stA4.png","庞杰铖","嵊州市人民医院","肝胆外科","住院医师",210,0,"肝癌三期治疗的关键：替雷利珠单抗与仑伐替尼的实用指南","","https://ystcdn.venuertc.com/venue/AI/ff95bc3b-0976-48a2-952f-fcfb4a4dc58f.jpg","\u003Cdiv id=\"material_title\">\n  \u003Ch1 style=\"font-size: 36px; line-height: 1.3; font-weight: 700; text-align: center; color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">\n    肝癌三期治疗的关键：替雷利珠单抗与仑伐替尼的实用指南\n    \u003Cspan style=\"font-size:28px;vertical-align:middle;\">💊🩺\u003C/span>\n  \u003C/h1>\n\u003C/div>\n\n\u003C!-- 目录导航 -->\n\u003Cdiv class=\"guide_navblock\" style=\"max-width:820px;margin:0 auto 30px auto;padding:16px 30px;background:linear-gradient(90deg, #e9eef6 0%, #f0f5fa 100%);box-shadow:0 2px 8px rgba(48,65,94,0.07);border-radius:18px;\">\n  \u003Cstrong style=\"font-size:20px;color:#2a426b;\">内容提要：\u003C/strong>\n  \u003Cul style=\"margin:16px 0 0 0;padding-left:18px;font-size:16px;color:#404a57;line-height:2.2;\">\n    \u003Cli>替雷利珠单抗与仑伐替尼的作用机制有哪些？\u003C/li>\n    \u003Cli>这两种药品如何正确使用？\u003C/li>\n    \u003Cli>有哪些常见不良反应及处理方法？\u003C/li>\n    \u003Cli>特殊人群应该如何调整剂量？\u003C/li>\n    \u003Cli>药物之间会不会互相影响？\u003C/li>\n    \u003Cli>储存与过量服用应该注意什么？\u003C/li>\n    \u003Cli>实际用药案例经验分享\u003C/li>\n    \u003Cli>全文引用权威英文资料与数据\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 开头引入 -->\n\u003Cdiv class=\"intro_block\" style=\"max-width:800px;margin:0 auto 32px auto;padding:22px 28px;background:linear-gradient(90deg,#fff9ef 0%,#f3f8ff 100%);border-radius:16px;font-size:19px;color:#2c3c59;line-height:2;\">\n  \u003Cp>提到肝癌三期的治疗，用到得最多的免疫与靶向药，非替雷利珠单抗和仑伐替尼莫属。这两种药品在联合方案中应用越来越广，但很多人对它的具体用法和关键注意事项还不清楚。其实，安全用药关键就在于细节。下面就带大家了解这两类药品的6大实用指导和实际用药经验。\u003C/p>\n\u003C/div>\n\n\u003C!-- 用药机制（药理作用） -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:36px 32px;background:#f7f9fc url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:right top;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 14px rgba(60,88,140,0.06);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">01. 药品作用机制简介 \u003Cspan style=\"font-size:22px;\">🧬\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.1;color:#294060;\">\n    \u003Cli>\u003Cb>替雷利珠单抗：\u003C/b> 这是一种免疫检查点抑制剂（PD-1单抗），通过阻断PD-1与其配体作用，增强人体自身免疫系统对异常细胞的识别与清除。\u003C/li>\n    \u003Cli>\u003Cb>仑伐替尼：\u003C/b> 属于多靶点酪氨酸激酶抑制剂，可以抑制血管内皮生长因子（VEGF）及相关信号通路，从而阻断异常细胞生长所需的血管生成。\u003C/li>\n    \u003Cli>两者联合应用可协同增强体内免疫活性，同时干扰异常细胞的生存环境，提升治疗效果。\u003C/li>\n    \u003Cli>\u003Cspan style=\"color:#167F39;\">权威引述：\u003C/span> 临床文献显示，仑伐替尼与免疫药物联合方案可提高有效率至36%左右，相比单药疗法更优。（引用：Finn RS, et al., \"Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma\", 2020, NEJM）\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 剂型与用法规范 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:34px 30px;background:#fbf4ed url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:center top;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(160,109,24,0.04);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">02. 剂型规格及服用技巧 \u003Cspan style=\"font-size:22px;\">💡\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.15;color:#406a26;\">\n    \u003Cli>\u003Cb>替雷利珠单抗：\u003C/b>常用为注射剂型，规格为240mg/瓶。经静脉滴注，推荐每三周一次。\u003C/li>\n    \u003Cli>正确做法：必须由专业医师在医疗机构内操作，每次用药前需严格检查药品批号、效期、稀释比例。\u003C/li>\n    \u003Cli>\u003Cb>仑伐替尼：\u003C/b>口服胶囊剂型，常见规格4mg和10mg。\u003C/li>\n    \u003Cli>服药方法：每天同一时间整片吞服，用温水送服，不可嚼碎。\u003C/li>\n    \u003Cli>需要注意：空腹或餐后均可服用，但坚持规律时间有利于药效稳定。随意改变服药方式可能影响作用。\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 用药剂量规范部分 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:34px 30px;background:#e7f7f6 url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:right bottom;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(38,137,130,0.04);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">03. 用药剂量与调整 \u003Cspan style=\"font-size:22px;\">⏳\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.05;color:#23746e;\">\n    \u003Cli>\u003Cb>替雷利珠单抗注射：\u003C/b> 单次静脉滴注240mg。三周一次。标准剂量不建议随意调整。\u003C/li>\n    \u003Cli>\u003Cb>仑伐替尼口服：\u003C/b> 成年人体重≥60kg者建议每日12mg；体重<60kg者建议每日8mg。\u003C/li>\n    \u003Cli>正确做法：首次服用后，根据耐受情况和实验室检查由医生决定是否需减量。切勿自行变更剂量。\u003C/li>\n    \u003Cli>特殊情况处理：如出现明显不良反应（见后文），须联系专业医师评估是否暂缓或减量。\u003C/li>\n    \u003Cli>数据表明：仑伐替尼减量策略能降低副作用发生率至20%以下。（引用：Kudo M, et al., \"Lenvatinib in Unresectable Hepatocellular Carcinoma\", 2018, Lancet）\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 药物相互作用 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:36px 30px;background:#f3f9e6 url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:left top;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(43,120,29,0.05);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">04. 药物相互作用与组合用药 \u003Cspan style=\"font-size:22px;\">🔗\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.15;color:#427537;\">\n    \u003Cli>\u003Cb>仑伐替尼：\u003C/b> 需避免与强效CYP3A4抑制剂如伊曲康唑、酮康唑等同时使用，因可加剧药物副作用。\u003C/li>\n    \u003Cli>同时服用利福平等CYP3A4诱导剂可能降低血药浓度。\u003C/li>\n    \u003Cli>\u003Cb>替雷利珠单抗：\u003C/b> 尚无明确药物相互作用，但不推荐与其他免疫抑制剂协同使用，以免抵消药效。\u003C/li>\n    \u003Cli>组合用药原则：必须由医师检查药品清单，逐项审查是否有潜在交互反应。\u003C/li>\n    \u003Cli>临床提示：部分患者接受联合治疗时，应与现用药物间隔至少1小时以上。\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 用药禁忌部分 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:36px 30px;background:#ece7fa url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:left bottom;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(117,82,173,0.06);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">05. 用药禁忌及特殊人群用药调整 \u003Cspan style=\"font-size:22px;\">🚫\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.04;color:#584071;\">\n    \u003Cli>\u003Cstrong>替雷利珠单抗：\u003C/strong>对药品成分过敏者禁用。\u003C/li>\n    \u003Cli>孕期及哺乳期禁止使用，因药物可能影响胎儿或婴儿。\u003C/li>\n    \u003Cli>肾功能重度减退患者慎用，需定期检查。\u003C/li>\n    \u003Cli>\u003Cstrong>仑伐替尼：\u003C/strong> 孕妇、哺乳期、严重肝肾损伤者禁用。\u003C/li>\n    \u003Cli>老年人使用时建议起始剂量减半，由医师监测调整。\u003C/li>\n    \u003Cli>儿童不推荐使用此类药品。\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 不良反应及处理方法 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:36px 30px;background:#f7e8e7 url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:right top;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(225,92,76,0.05);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">06. 不良反应与应对办法 \u003Cspan style=\"font-size:22px;\">⚠️\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.15;color:#a25252;\">\n    \u003Cli>\u003Cstrong>替雷利珠单抗：\u003C/strong>常见有注射部位反应（红肿、疼痛）、乏力、皮疹、偶有过敏。极少数可能出现免疫相关全身反应。\u003C/li>\n    \u003Cli>\u003Cstrong>仑伐替尼：\u003C/strong>可能引起高血压、食欲减退、腹泻、乏力，也可有蛋白尿、手足皮肤反应。\u003C/li>\n    \u003Cli>正确做法：出现轻度不适可观察，若持续加重或有严重表现（发热、持续性腹泻、明显皮疹等），应立即就医。\u003C/li>\n    \u003Cli>处理原则：不要自行停药，主动报告给主治医师，由医生评估是否调整方案。\u003C/li>\n    \u003Cli>临床数据：高血压在使用仑伐替尼时发生率约为40%，但绝大部分可通过降压药物控制。（引用：Kudo M, et al., 2018）\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 漏服与过量处理 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:36px 30px;background:#f3faeb url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:left top;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(47,146,40,0.06);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">07. 漏服与过量用药处理 \u003Cspan style=\"font-size:22px;\">⏰\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.03;color:#398321;\">\n    \u003Cli>\u003Cstrong>仑伐替尼：\u003C/strong>漏服后建议立即补服，若接近下一次服药，则跳过漏服剂量，不可一次服用两倍剂量。\u003C/li>\n    \u003Cli>过量服用可能引起剧烈不良反应，如高血压危象、严重乏力、消化道反应等。\u003C/li>\n    \u003Cli>正确做法：如出现过量服用，及早联系医生处理，不要自行催吐或增加其他药物。\u003C/li>\n    \u003Cli>\u003Cstrong>替雷利珠单抗：\u003C/strong>由于为院内给药，通常无漏服问题。若用量超标或给药频率不当，应及时通知专科人员进行现场处理。\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 储存条件与有效期 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:36px 30px;background:#e6eee6 url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:right bottom;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(97,113,92,0.07);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">08. 储存方式与有效期管理 \u003Cspan style=\"font-size:22px;\">📦\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.13;color:#365a37;\">\n    \u003Cli>\u003Cstrong>替雷利珠单抗：\u003C/strong>需冷藏，2-8℃避光保存。\u003C/li>\n    \u003Cli>开封后应及时使用，不可长时间放置。\u003C/li>\n    \u003Cli>\u003Cstrong>仑伐替尼：\u003C/strong>室温下（不高于30℃）避光、干燥储存。\u003C/li>\n    \u003Cli>过期药物应按医嘱安全销毁，绝不可继续服用。\u003C/li>\n    \u003Cli>药盒请保留至治疗结束，便于核查信息。\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 实际用药案例经验分享 -->\n\u003Cdiv class=\"section_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:36px 30px;background:#e3effb url('data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAE3RFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAA1JREFUeNpiYGBgAAAABAABJzQnCgAAAABJRU5ErkJggg==');background-position:left top;background-repeat:no-repeat;border-radius:20px;box-shadow:0 2px 12px rgba(56,114,171,0.08);\">\n  \u003Ch2 style=\"font-size: 26px; color: rgb(44, 62, 80); font-weight: 700; letter-spacing: 0.02em; margin: 1.2em 0px 0.6em; border-bottom: 1px solid rgb(238, 238, 238);\">09. 实际用药案例分享 \u003Cspan style=\"font-size:22px;\">👀\u003C/span>\u003C/h2>\n  \u003Cul style=\"font-size:18px;line-height:2.17;color:#21537c;\">\n    \u003Cli>有位男性患者在接受替雷利珠单抗联合仑伐替尼期间，由专科医生定期监测肝肾功能，调整仑伐替尼用量后副作用减轻。\u003C/li>\n    \u003Cli>临床上，部分患者采用院内滴注替雷利珠单抗时偶有皮疹表现，通过及时与医师沟通并短时停药，恢复顺利。\u003C/li>\n    \u003Cli>一位患者漏服仑伐替尼后谨遵单次补服规则，未出现不适，药效保持稳定。经验显示，严格遵医嘱是减少风险的关键。\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003C!-- 总结提升实用性 -->\n\u003Cdiv class=\"conclusion_block\" style=\"max-width:830px;margin:0 auto 38px auto;padding:38px 32px;background:#faf6f2;border-radius:20px;box-shadow:0 2px 16px rgba(115,105,98,0.08);font-size:19px;line-height:2.14;color:#463b31;\">\n  \u003Ch2 style=\"font-size: 24px; color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; letter-spacing: 0.01em; border-bottom: 1px solid rgb(238, 238, 238);\">结语与用药提醒 \u003Cspan style=\"font-size:22px;\">🔍\u003C/span>\u003C/h2>\n  \u003Cp>替雷利珠单抗和仑伐替尼的规范使用，对于安全获得最佳治疗结果至关重要。最值得注意的是：\u003C/p>\n  \u003Cul style=\"margin:18px 0 0 18px;font-size:18px;color:#5f511e;line-height:2.25;\">\n    \u003Cli>一定坚持规律给药，按剂量执行，每次服药前仔细核查。\u003C/li>\n    \u003Cli>出现副作用要及时与医生联系，切勿自作主张停药或增减剂量。\u003C/li>\n    \u003Cli>药物储存、过期处理须严格按照说明操作，防止影响药品安全。\u003C/li>\n    \u003Cli>如对组合用药有疑问，一定说出所有服用清单让医生检查，避免药物相互作用风险。\u003C/li>\n  \u003C/ul>\n  \u003Cp>安全用药不是只靠一次知识学习，更需要每次细致执行。遇到不适或异常，必须咨询专业医师。好了，这些用药细节你记住了吗？合理用药，安全常在。🛡️\u003C/p>\n\u003C/div>\n\n\u003C!-- 文献引用区块 -->\n\u003Cdiv class=\"reference_block\" style=\"max-width:820px;margin:0 auto 36px auto;padding:18px 22px;background:#eef6ff;border-radius:15px;box-shadow:0 1px 9px rgba(67,110,195,0.07);font-size:17px;color:#315297;\">\n  \u003Ch3 style=\"font-size: 20px; color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">参考文献\u003C/h3>\n  \u003Cul style=\"margin-left:17px;\">\n    \u003Cli>Finn RS, Qin S, Ikeda M, et al. (2020). Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma. \u003Ci>New England Journal of Medicine\u003C/i>, 382:1894–1905. https://doi.org/10.1056/NEJMoa1915745\u003C/li>\n    \u003Cli>Kudo M, Finn RS, Qin S, et al. (2018). Lenvatinib versus sorafenib in first-line treatment of unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. \u003Ci>Lancet\u003C/i>, 391(10126):1163-1173. https://doi.org/10.1016/S0140-6736(18)30207-1\u003C/li>\n    \u003Cli>Cheng AL, et al. (2019). Efficacy and safety of atezolizumab plus bevacizumab in Chinese patients with unresectable hepatocellular carcinoma. \u003Ci>Journal of Hepatology\u003C/i>, 71(3): Intermediate reference for combination therapy. https://doi.org/10.1016/j.jhep.2019.03.019\u003C/li>\n  \u003C/ul>\n\u003C/div>\n\n\u003Cstyle>\n/* 独立全局样式，仅用于药品科普块，不影响其他内容 */\n.guide_navblock, .intro_block, .section_block,\n.conclusion_block, .reference_block {\n  font-family: \"PingFang SC\", \"Segoe UI\", \"Arial\", \"Helvetica Neue\", \"sans-serif\";\n  box-sizing:border-box;\n}\n\n/* 标题样式独立 */\n#material_title h1 {\n  letter-spacing:0.02em;\n}\n\n/* 副标题样式独立 */\n.section_block h2, .conclusion_block h2, .reference_block h3 {\n  margin-top:0;\n}\n\n/* 列表样式独立 */\n.section_block ul, .conclusion_block ul, .reference_block ul, .guide_navblock ul {\n  padding-left:22px;\n  margin-top:0;\n  margin-bottom:0;\n}\n\n.section_block, .conclusion_block, .reference_block {\n  border: none;\n}\n\u003C/style>\n\n","\u003Cdiv id=\"material_title\">\n  \u003Ch1 style=\"font-size: 36px; line-height: 1.3; font-weight: 700; text-ali",510,"2025-09-17 11:55:05","肝癌, 替雷利珠单抗, 仑伐替尼, 药物相互作用, 不良反应","本指南提供替雷利珠单抗与仑伐替尼的使用技巧、药物相互作用及不良反应处理，帮助患者安全用药，实现最佳治疗效果。","2025-10-20 14:26:13",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]