[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$f0XSdcSPIIyxm5ELHNecCQMRCyaMRprGFP0_dUbVPl4M":8,"$fmw0YQIV1nzCjrlXBfDFf9AQODX3lokPawMsOgyYxkA4":55,"$f5qEu3T2uaybAkqu6CrnOek0JtODODWnHQbzVtbCtHEI":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},66088,870559,[],"https://cdn.yishi-tong.com/console/store-unknown/uF7OMd0P_hB1LaAPsAH23kXFsYY6stA4.png","王灵伟","阳城县人民医院","肿瘤科","住院医师",13,0,"有效应对肝癌：仑伐替尼与索拉菲尼治疗指南","","https://cdn.yishi-tong.com/console/store-26/jcz3NQmqfoUMuFkc82EhCK7t9eFhaPh6.png","\u003Ch2 id=\"material_title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">有效应对肝癌：仑伐替尼与索拉菲尼治疗指南\u003C/h2>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #e8f3fa 0%, #f7fafc 100%); padding: 18px 0; font-size: 1.3em;\">\n    01 仑伐替尼与索拉菲尼：基本认识\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    仑伐替尼和索拉菲尼，都是目前肿瘤领域较常用的靶向药物，主要以口服片剂形式上市。两者都属于多靶点酪氨酸激酶抑制剂，通过干预细胞内信号传导，阻止肿瘤区域血管生成，从而实现抑制肿瘤生长的效果。\u003Cbr>\n    \u003Cspan class=\"drug-highlight\">主要成分：\u003C/span>仑伐替尼（Lenvatinib）与索拉菲尼（Sorafenib）。\u003Cbr>\n    \u003Cspan class=\"drug-highlight\">常见规格：\u003C/span>\u003Cbr> \n    👉 仑伐替尼：4mg、10mg片剂，作为标准制剂广泛流通。\u003Cbr>\n    👉 索拉菲尼：200mg片剂，每片含盐酸索拉菲尼200毫克。\u003Cbr>\n    服用时无需借助辅助设备，直接以水送服。\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #f0ecf7 0%, #fcfbfe 100%); padding: 18px 0; font-size: 1.3em;\">\n    02 药物作用机制简述\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    两款药物都是多靶点抑制剂，其核心机制相当于“切断肿瘤供应线”\u003Cspan style=\"margin-left:4px;\">🚧\u003C/span>。仑伐替尼主要抑制 VEGF、FGF、PDGF、RET等多种酪氨酸激酶，索拉菲尼则同时抑制肿瘤细胞增殖通路和新生血管生成。\u003Cbr>\n    \u003Cstrong>不与细胞直接作用，而是调整细胞环境，使肿瘤区域血液供应受限，减少肿瘤营养获取，最终达到抑制肿瘤生长的作用。\u003C/strong>（Matsui et al., 2017；Llovet et al., 2008）\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #e7fae8 0%, #f7fcf8 100%); padding: 18px 0; font-size: 1.3em;\">\n    03 正确使用方法及服药时间 🕰️\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cul style=\"padding-left:24px;list-style:disc;\">\n      \u003Cli>\u003Cstrong>仑伐替尼：\u003C/strong>通常每日一次，每次用量根据体重决定：\n        \u003Cul style=\"margin-top:4px;\">\n          \u003Cli>≥60kg：建议起始剂量12mg/日。\u003C/li>\n          \u003Cli><60kg：建议起始剂量8mg/日。\u003C/li>\n        \u003C/ul>\n        具体剂量需医生根据实际情况调整。\n      \u003C/li>\n      \u003Cli>\u003Cstrong>索拉菲尼：\u003C/strong>通常每日两次，每次400mg（即2片），间隔12小时。请用一杯温水整片吞服，禁止掰开或嚼碎。\u003C/li>\n      \u003Cli>建议服药时间：餐前或餐后均可，但推荐空腹1小时或餐后2小时服用，以防食物影响药物吸收。\u003C/li>\n    \u003C/ul>\n    \u003Cspan class=\"tip-box\" style=\"background: #fffbe8; border-left: 3px solid #ffd700; padding:6px 11px; display:inline-block; margin-top: 11px;\">正确做法：每次用量须遵医嘱，切勿自行增减。漏服时不可随意补充双倍剂量。\u003C/span>\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #dae6f6 0%, #f2f7fa 100%); padding: 18px 0; font-size: 1.3em;\">\n    04 剂型特点和服用技巧\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cspan class=\"drug-highlight\">仑伐替尼：\u003C/span>棕黄色片剂，质地坚硬，整片吞服不宜掰碎。尤其对于有吞咽障碍的老年人，可用一整杯水辅助吞咽（约150ml），确保药片顺利通过食道，防止黏附。\n    \u003Cbr>\n    \u003Cspan class=\"drug-highlight\">索拉菲尼：\u003C/span>浅黄色薄膜包衣片，建议餐前吞服。禁止剥除包衣，否则可能影响释放速度和吸收效果。\n    \u003Cbr>\n    特别提醒：药片如有破损或过软，建议直接更换新药片，避免药效受损。\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #f9f4eb 0%, #fcf8f2 100%); padding: 18px 0; font-size: 1.3em;\">\n    05 药物相互作用与合用药注意事项 👩‍⚕️\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cstrong>仑伐替尼：\u003C/strong>有多种药物相互作用：\n    \u003Cul style=\"padding-left:24px;list-style:disc;\">\n      \u003Cli>与CYP3A4酶抑制剂（如酮康唑）合用可能增加仑伐替尼血药浓度。\u003C/li>\n      \u003Cli>与抗凝药、降压药需慎用，避免血压和出血风险增加。\u003C/li>\n      \u003Cli>同时服用葡萄柚汁可影响药物代谢，应避免。\u003C/li>\n    \u003C/ul>\n    \u003Cstrong>索拉菲尼：\u003C/strong>\n    \u003Cul style=\"padding-left:24px;list-style:disc;\">\n      \u003Cli>与华法林、咯噻嗪等抗凝药物可能增加出血风险。\u003C/li>\n      \u003Cli>与CYP3A4酶诱导剂（如利福平）合用时药效降低。\u003C/li>\n      \u003Cli>不可与高脂膳食同服，否则吸收可能增强，从而引发更多不良反应。\u003C/li>\n    \u003C/ul>\n    \u003Cspan class=\"tip-box\" style=\"background: #e7f7ff; border-left: 3px solid #1c76ab; padding:6px 11px; display:inline-block; margin-top: 11px;\">\n      用药期间如需合用其他药物，请提前向医生报备，避免药效变化和副作用累积。\n    \u003C/span>\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #f0f8ed 0%, #f5fcf5 100%); padding: 18px 0; font-size: 1.3em;\">\n    06 特殊人群用药注意 🔬\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cul style=\"padding-left:24px;list-style:disc;\">\n      \u003Cli>老年人（65岁以上）：肾、肝代谢能力下降，建议从低剂量起步，逐步调整至目标剂量；应严密监测血压和肾功能。\u003C/li>\n      \u003Cli>肝功能不全患者：需提前评估肝酶（转氨酶）及蛋白合成能力，必要时降低用量或暂停用药。\u003C/li>\n      \u003Cli>孕妇和哺乳期女性：两药均有潜在致畸性和泌乳抑制，需绝对禁止使用。\u003C/li>\n      \u003Cli>儿童或青少年：目前尚无足够安全性数据，不建议18岁以下使用。\u003C/li>\n    \u003C/ul>\n    \u003Cspan class=\"tip-box\" style=\"background: #fae7ee; border-left: 3px solid #d43e8f; padding:6px 11px; display:inline-block; margin-top: 11px;\">正确做法：特殊群体首次用药须在医生完整评估下进行，每次调整都需复查相关生化指标。\u003C/span>\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #ffe6e6 0%, #fff8f7 100%); padding: 18px 0; font-size: 1.3em;\">\n    07 常见不良反应与处理方法 🩺\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cspan class=\"drug-highlight\">仑伐替尼：\u003C/span>常见不良反应包括高血压（发病率30-40%）、蛋白尿、乏力、食欲减退和胃肠道不适。出现高血压的时候，一般需加用降压药，蛋白尿严重者要停药观察。（Kudo et al., 2018）\n    \u003Cbr>\n    \u003Cspan class=\"drug-highlight\">索拉菲尼：\u003C/span>易出现皮疹、手足症候群（红肿、脱皮）、腹泻及轻度血压升高。皮疹局部可用低浓度糖皮质激素乳膏，如持续恶化请及时就医。\n    \u003Cbr>\n    严重不良反应如持续高血压、重度蛋白尿或严重脱水，必须暂停用药并尽快联系专业医生，而不是等待症状自行缓解。\n    \u003Cspan class=\"tip-box\" style=\"background: #f7effa; border-left: 3px solid #8d77b3; padding:6px 11px; display:inline-block; margin-top: 11px;\">出现副作用时不要自行停药，务必先与医生沟通，经过专业评估后决定是否调整用药。\u003C/span>\n    \u003Cbr>\n    \u003Cspan class=\"case-highlight\" style=\"background: #faf9ea; border-radius: 8px; padding:10px 18px; display:block; margin-top:14px;\">\n      案例分享：一位67岁男性，服用靶向药物期间出现高血压和蛋白尿，经及时复查及调整降压药后，成功稳定血压并继续用药。\n    \u003C/span>\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #edf7fc 0%, #fbfdfe 100%); padding: 18px 0; font-size: 1.3em;\">\n    08 药品储存和有效期管理 🧊\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    两款药品均需放置于阴凉干燥处，建议室温（15-30℃）保存，远离强光和潮湿环境。冷藏并不推荐，避免受潮结块。\n    \u003Cbr>\n    开封后药品务必使用原包装密封保存，超过有效期或发现片剂颜色异常、片剂破损，应直接废弃，不要继续使用。\n    \u003Cspan class=\"tip-box\" style=\"background: #e8fbfa; border-left: 3px solid #22b3ac; padding:6px 11px; display:inline-block; margin-top: 11px;\">过期药品可通过医疗机构或药店回收，不建议自行丢弃，以防环境污染。\u003C/span>\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #f6f2ee 0%, #fcfbf3 100%); padding: 18px 0; font-size: 1.3em;\">\n    09 漏服和过量处理方法\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cstrong>漏服处理：\u003C/strong>如发现漏服，应在当日尽快补服一次，但如果临近下次服药时间，略过漏服，按原计划继续即可。切勿同一天内重复多次服用。\n    \u003Cbr>\n    \u003Cstrong>过量风险：\u003C/strong>一次过量服用可能导致严重高血压、肾功能损失及急性肠胃不适。出现上述症状后应及时就诊，进行相关检查和洗胃监护。\n    \u003Cbr>\n    正确做法：家中备药时可用药品分隔盒辅助记录服用情况，避免遗忘或重复。\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #e8f7fd 0%, #f7fafc 100%); padding: 18px 0; font-size: 1.3em;\">\n    10 用药管理与日常监控 📆\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cul style=\"padding-left:24px;list-style:disc;\">\n      \u003Cli>用药期间建议每1-2周复查血压、尿蛋白和肾功能。\u003C/li>\n      \u003Cli>长期服用者要定期做肝肾功能检测，评估是否需要调整剂量。\u003C/li>\n      \u003Cli>饮食以高蛋白、低盐为主，配合日常监控，减少蛋白尿风险。\u003C/li>\n      \u003Cli>避免剧烈运动和暴露在高温潮湿环境。\u003C/li>\n    \u003C/ul>\n    \u003Cspan class=\"tip-box\" style=\"background: #fefbe9; border-left: 3px solid #bea155; padding:6px 11px; display:inline-block; margin-top: 11px;\">发生任何药品相关不适时，应尽快咨询医生，不建议自行调整方案。\u003C/span>\n  \u003C/div>\n\u003C/div>\n\n\u003Cdiv class=\"drug-section\" style=\"margin-top:30px;\">\n  \u003Cdiv class=\"section-title\" style=\"background: linear-gradient(90deg, #eeeeee 0%, #fcfcfc 100%); padding: 18px 0; font-size: 1.3em;\">\n    11 结尾总结与安全提示\n  \u003C/div>\n  \u003Cdiv class=\"section-content\" style=\"padding: 14px 0;\">\n    \u003Cstrong>仑伐替尼和索拉菲尼都是口服靶向药，选用时需严格遵循剂量规范和服药技巧，切记定期监测不良反应，及时调整方案。\u003C/strong>\n    \u003Cbr>\n    两款药品优势在于：可直接作用于肿瘤相关通路，实现持续抑制，不需住院即可使用。但重要的是，务必注意合用药物、饮食与用药方式，尤其高血压和肾功能问题要密切关注。\n    \u003Cbr>\u003Cbr>\n    最后，合理用药提高疗效，确保安全是首要目标。如遇到不良反应或疑惑，请及时联系医生或药师，不要自行改动用药计划。\n  \u003C/div>\n\u003C/div>\n\n\u003C!-- 文献参考 -->\n\u003Cdiv class=\"ref-section\" style=\"background: #f7fbfc; padding: 24px 12px; border-radius: 8px; margin-top:30px;\">\n  \u003Cdiv style=\"font-size:1.1em; font-weight:600; margin-bottom:12px;\">\n    参考文献\n  \u003C/div>\n  \u003Col style=\"padding-left:20px;\">\n    \u003Cli>Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J. F., et al. (2008). Sorafenib in advanced hepatocellular carcinoma. \u003Ci>The New England Journal of Medicine\u003C/i>, 359(4), 378-390.\u003C/li>\n    \u003Cli>Matsui, J., Funahashi, Y., Uenaka, T., Watanabe, T., Tsuruoka, A., & Asada, M. (2017). Multi-kinase inhibitor E7080 suppresses tumor cell proliferation and angiogenesis. \u003Ci>Cancer Science\u003C/i>, 99(8), 1598–1607.\u003C/li>\n    \u003Cli>Kudo, M., Finn, R. S., Qin, S., Han, K. H., Ikeda, K., Piscaglia, F., et al. (2018). Lenvatinib versus sorafenib in first-line treatment of unresectable hepatocellular carcinoma. \u003Ci>The Lancet\u003C/i>, 391(10126), 1163–1173.\u003C/li>\n  \u003C/ol>\n\u003C/div>\n\n\u003Cstyle>\n.material_title {\n  color: #225885; font-weight:700; font-size:2em;\n  margin-bottom:34px; text-align:left;\n}\n.drug-section {\n  margin-bottom:38px;\n}\n.section-title {\n  font-weight:600;\n  border-radius:8px;\n  color:#2a495a;\n  letter-spacing:0.5px;\n  margin-bottom: 12px;\n}\n.section-content {\n  font-size:1.05em;\n  color:#383f45;\n  line-height:1.8;\n  padding-left: 10px;\n}\n.drug-highlight {\n  color:#225885;\n  font-weight:600;\n  padding:2px 2px;\n}\n.tip-box {\n  font-size: 1em;\n  font-weight:500;\n  border-radius:8px;\n}\n.case-highlight {\n  font-size: 1em;\n  font-style:italic;\n  border-radius:8px;\n}\n.ref-section {\n  font-size:0.96em;\n  color:#334750;\n}\n@media screen and (max-width: 600px) {\n  .section-title { font-size:1.04em !important; padding: 14px 0 !important;}\n  .material_title { font-size:1.55em !important;}\n  .section-content { font-size:0.98em !important;}\n  .ref-section { font-size:0.89em;}\n}\n\u003C/style>\n\n","\u003Ch2 id=\"material_title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; bo",521,"2025-09-11 19:03:36","肝癌, 仑伐替尼, 索拉菲尼, 治疗指南, 不良反应, 服药注意事项, 癌症治疗, 靶向药物","本文详细介绍了仑伐替尼和索拉菲尼的使用指南，涵盖基本信息、服用方法与不良反应，旨在帮助患者安全有效地抗击肝癌，获取更好的治疗成果。","2025-09-13 09:30:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]