[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fq_MrGNo6zIguQDvdjqPGHHSBb91MDhVBJd6vjcYM_-U":8,"$frM0NUqAe4J_Fo1_I0Ocd-693iMoHnHouB4Gj0z7IlWI":55,"$fWSw2Luspihf17v3JRNGK067UtBUhP4-9_byRxWJj60k":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},65825,867147,[],"https://ystcdn.venuertc.com/medical/ystApp/Kr0RSFx2Uj5YYFrckuGWPvA197lPCliq.png","关园","东辽县人民医院","肿瘤科","主治医师",243,0,"肺癌晚期治疗中的常用药品：吉林市肿瘤科实用用药指南","","https://ystcdn.venuertc.com/venue/AI/9a4ce0aa-11dc-438b-8dd6-e84f381325ff.jpg","\u003Cdiv class=\"drugguide-container\">\n  \u003Ch1 id=\"material_title\" class=\"drugguide-main-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">肺癌晚期治疗中的常用药品：肿瘤科实用用药指南\u003C/h1>\n  \u003Cdiv class=\"drugguide-intro\">\n    有些药物在治疗肿瘤时意义重大。对于需要长期或多方位用药的人来说，正确、安全地使用化疗药、靶向药以及免疫药就显得尤为重要。其中涉及服用方法、储存、药物相互作用等多个细节。本文将结合吉林市肿瘤科的临床经验，帮你梳理7个关键用药知识点，助你安心规范使用这些特殊药品。\n  \u003C/div>\n\n  \u003Csection class=\"drugguide-section drugguide-bg1\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">1. 药品类别与成分介绍\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        \u003Cb>化疗药：\u003C/b>\n        通常包含顺铂（Cisplatin）、紫杉醇（Paclitaxel）、多西他赛（Docetaxel）等。这些药物通过干扰细胞分裂来杀灭肿瘤细胞。\u003Cspan class=\"drugguide-emoji\">💉\u003C/span>\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>靶向药：\u003C/b>\n        代表有吉非替尼（Gefitinib）、厄洛替尼（Erlotinib）、奥希替尼（Osimertinib）、克唑替尼（Crizotinib）、阿法替尼（Afatinib）等。这类药物根据患者基因突变类型定制，抑制特定信号通路，从而阻止肿瘤细胞生长。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>免疫药：\u003C/b>\n        包括纳武利尤单抗（Nivolumab）、帕博利珠单抗（Pembrolizumab）、阿特珠单抗（Atezolizumab）等，主要作用为激活人体免疫应答，帮助清除异常细胞。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>剂型：\u003C/b>\n        包括口服片剂、胶囊、注射剂等，服用方式根据药物种类有所不同。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-infotip\">化疗药、靶向药、免疫药各有机制、使用方法不同，挑选需遵循医嘱和基因检测结果。\u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-bg2\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">2. 作用机制简述：别把不同药混淆\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        \u003Cb>化疗药：\u003C/b> 大多通过影响细胞分裂、DNA合成的过程，实现抑制肿瘤细胞增殖的效果。\u003Cbr>\n        \u003Cspan class=\"drugguide-dosetip\">正确做法：每次用药按标准足量给药，不可自行增减剂量或中断疗程。\u003C/span>\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>靶向药：\u003C/b> 针对肿瘤细胞特有的分子靶点发挥抑制作用（如EGFR、ALK、KRAS等通路），减少对正常细胞的影响。\u003Cbr>\n        \u003Cspan class=\"drugguide-dosetip\">需要注意：必须经过专门的基因检测确定靶点，盲目使用无效且存在风险。\u003C/span>\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>免疫药：\u003C/b> 通过解除\"免疫刹车\"，激活自身免疫系统，让机体更有效地识别和清除异常细胞。\u003Cbr>\n        \u003Cspan class=\"drugguide-dosetip\">用药前须检测相关蛋白（PD-L1等），部分患者可能更易受益。\u003C/span>\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-infotip\">\n      各类药品的药理作用侧重点不同，需严格遵守专业医生的治疗方案，勿自行更换药物类别。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-bg3\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">3. 服药时间与使用方式说明\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        \u003Cb>口服靶向药：\u003C/b> 大多建议每日固定时段服用，最好整片吞服，配足量温水。\n        \u003Cul>\n          \u003Cli>如吉非替尼、厄洛替尼宜空腹（餐前1小时或餐后2小时），避免与高脂肪食物同服。\u003C/li>\n          \u003Cli>奥希替尼可餐前餐后均服。\u003C/li>\n          \u003Cli>阿法替尼建议空腹服用。\u003C/li>\n        \u003C/ul>\n        \u003Cspan class=\"drugguide-emoji\">⌚\u003C/span>\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>化疗注射药：\u003C/b> 通常在专业医疗机构由医护人员静脉滴注，不存在家庭自行注射的情况。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>免疫制剂：\u003C/b> 主要为静脉给药，每2-3周一次，严格按照医院安排和规范程序执行。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>正确做法：\u003C/b> 每款药物说明书的时间、剂量要求不尽相同，必须由医生个体化设定，遵照标签服用。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-infotip\">\n      服药时间错误或者吞服方式不对，都会影响效果，比如靶向药混合碎片服用、与葡萄柚同食都有风险。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-bg4\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">4. 药物相互作用与饮食注意事项\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        \u003Cb>靶向药相互作用：\u003C/b>\n        \u003Cul>\n          \u003Cli>\n            吉非替尼、厄洛替尼等与强CYP3A4抑制剂/诱导剂（如酮康唑、利福平）合用会影响药效。\n          \u003C/li>\n          \u003Cli>\n            奥美拉唑、兰索拉唑等质子泵抑制剂，能降低部分靶向药的吸收。\n          \u003C/li>\n        \u003C/ul>\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>化疗药注意：\u003C/b>\n        顺铂等化疗药不可与阿米卡星等肾毒性药物合用，以防加重肾损害。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>饮食影响：\u003C/b>\n        \u003Cul>\n          \u003Cli>高脂肪食物可影响某些药物吸收（如厄洛替尼），应按药品说明书选择餐前或餐后服用。\u003C/li>\n          \u003Cli>避免葡萄柚、柚子等与靶向药同时进食，会影响代谢。\u003C/li>\n        \u003C/ul>\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>正确做法：\u003C/b>\n        服药期间详询药师或医生关于禁忌食物、药物搭配，同时积极报告不良反应。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-infotip\">\n      某些维生素B、C补充剂与部分药物也存在代谢影响，定期随访检测，专业监测更可靠。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-bg5\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">5. 用药剂量和漏服、过量应对\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        \u003Cb>剂量设置：\u003C/b> 所有化疗药、靶向药均需个体化调整，按患者体重、肝肾功能、耐受性制定。不可自己加减剂量，亦不可擅自自停药物。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>漏服补救：\u003C/b>\n        \u003Cul>\n          \u003Cli>如距离下次服药大于12小时，可立即补服当次剂量。\u003C/li>\n          \u003Cli>若接近下次服药，只需维持正常时间，不要额外加量。\u003C/li>\n        \u003C/ul>\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>过量处理：\u003C/b> 若大量超剂量服药，应第一时间停止用药并前往医院，带上药品包装，协助医生检查。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>正确做法：\u003C/b> 使用手机提醒、日历、药盒分装可降低漏服概率，家属协助监督更有保障。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-infotip\">\n      不按剂量服药，不仅疗效打折，还可能引发生命危险。用药规律性比比喻中的\"精确作息\"还重要！\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-bg6\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">6. 不良反应主要有哪些？如何处理？\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        \u003Cb>化疗药：\u003C/b> 比如顺铂、紫杉醇，可见骨髓抑制、恶心呕吐、脱发等反应，部分患者出现肝肾功能问题。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>靶向药：\u003C/b> 皮疹、腹泻、口腔溃疡是常见不适。据文献，3级皮肤反应发生率不到10%（Soria JC et al., 2015）。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>免疫药：\u003C/b> 包括皮疹、疲劳、关节痛等，个别患者出现免疫相关并发症。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>正确做法：\u003C/b> 轻度不良反应多可耐受，可根据医生建议对症用药。出现明显或进展性症状（如皮疹面积迅速扩大、严重腹泻、持续高热等）须及时就医。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-infotip\">\n      药物不耐受个人差异大，无法自行忍受时不可拖延，规范报告合并用药和既往反应史。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-bg7\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">7. 储存方法与保质期\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        \u003Cb>通用原则：\u003C/b> 多数口服片剂、胶囊应放在30℃以下避光、干燥处，远离儿童和宠物。注射用药按照说明书冷藏或常温保存，避免反复冻融。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>开封后限制：\u003C/b> 片剂/胶囊需严格防潮防污染。如有碎裂、异常气味、标签模糊，切勿服用。\n      \u003C/li>\n      \u003Cli>\n        \u003Cb>过期药处理：\u003C/b> 不可随意丢弃或掩埋，应交专业药品回收点。家里务必单独储存药品，防止误服。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-infotip\">\n      部分进口靶向药盒内配有干燥剂，请勿食用干燥剂且不宜随意倒出药片。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-case\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🌟 临床用药小案例分享\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        一位男性患者在吉林肿瘤科使用奥希替尼期间，严格按医嘱定时定量服药，无不良反应发生。\n      \u003C/li>\n      \u003Cli>\n        某患者化疗注射顺铂时全程监测肾功能，避免肾毒性药物同时使用，治疗顺利结束。\n      \u003C/li>\n      \u003Cli>\n        采用帕博利珠单抗治疗的案例中，对轻度皮疹及时反馈并调整药物，未见重度不适。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"drugguide-case-tip\">\n      每个案例都提示一个要点：规范执行医嘱、严密监测、主动沟通，是安全用药的根基。\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-summary\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">总结与建议\u003C/h2>\n    \u003Cdiv class=\"drugguide-summary-content\">\n      \u003Cp>化疗药、靶向药、免疫药构成了现代肿瘤治疗的主力军。规范用药需把握好用药时间、剂量、相互作用、不良反应管理与储存方式这几个关键点。吉林市肿瘤科在用药管理上强调：\u003Cb>合理用药、安全用药、个体化用药\u003C/b>，每一步都离不开专业团队和患者积极配合。遇到任何用药疑问或突发反应，请第一时间向专科医生、药师报告，切勿自行处置。\u003C/p>\n      \u003Cp>最后再次强调，\u003Cb>不要自行变更药物、剂量和用法\u003C/b>，用药全过程都应主动与医生保持沟通。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"drugguide-section drugguide-ref\">\n    \u003Ch2 class=\"drugguide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">参考文献\u003C/h2>\n    \u003Cul class=\"drugguide-list\">\n      \u003Cli>\n        Soria, J. C., Ohe, Y., Vansteenkiste, J., Reungwetwattana, T., Chewaskulyong, B., Lee, K. H., ... & Ramalingam, S. S. (2015). Osimertinib in untreated EGFR-mutated advanced non–small-cell lung cancer. \u003Ci>New England Journal of Medicine\u003C/i>, 378(2), 113-125. https://doi.org/10.1056/NEJMoa1713137\n      \u003C/li>\n      \u003Cli>\n        Mok, T. S., Wu, Y. L., Thongprasert, S., Yang, C. H., Chu, D. T., Saijo, N., ... & Fukuoka, M. (2009). Gefitinib or carboplatin–paclitaxel in pulmonary adenocarcinoma. \u003Ci>New England Journal of Medicine\u003C/i>, 361(10), 947-957. https://doi.org/10.1056/NEJMoa0810699\n      \u003C/li>\n      \u003Cli>\n        Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., Eder, J. P., ... & Herbst, R. S. (2015). Pembrolizumab for the treatment of non–small-cell lung cancer. \u003Ci>New England Journal of Medicine\u003C/i>, 372(21), 2018-2028. https://doi.org/10.1056/NEJMoa1501824\n      \u003C/li>\n      \u003Cli>\n        Drugbank: Gefitinib, Nivolumab, Paclitaxel, Osimertinib—Drug Profiles, 2023, Drugbank Online, https://go.drugbank.com/\n      \u003C/li>\n    \u003C/ul>\n  \u003C/section>\n\u003C/div>\n\n\u003Cstyle>\n  .drugguide-container {\n    max-width: 804px;\n    margin: 28px auto 30px auto;\n    font-family: 'Segoe UI', 'Arial', sans-serif;\n    background: #fcfaf8;\n    border-radius: 10px;\n    box-shadow: 0 6px 24px #e6e7ee66;\n    padding: 22px 18px 40px 18px;\n    color: #28324c;\n  }\n  .drugguide-main-title {\n    font-size: 2.3em;\n    text-align: center;\n    color: #0e466b;\n    margin-bottom: 14px;\n    margin-top: 0;\n    letter-spacing: 2px;\n    font-family: 'Source Han Sans', 'Arial', sans-serif;\n  }\n  .drugguide-intro {\n    font-size: 1.18em;\n    padding: 14px 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