[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fNoId2i-GeuGHxQn1JK-4OgKLlyaTEIK1fGz5n9cLFh0":8,"$fo47kJ7Uk2TKp-KIo7tFHt2hhp7QaLZmUO2Li69cVL7M":55,"$f2SaSOKpcSHiZp-5508hcRFNMTsu_1oDVFG_IaR-9jcA":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},65524,863254,[],"https://ystcdn.venuertc.com/medical/ystApp/Dlmj9URvs7gXdepZpARivDbqwZwkg06p.png","朱永亮","龙口南山养生谷肿瘤医院","放射科","住院医师",397,0,"胃癌晚期化疗与靶向用药：全方位安全服药指南","","https://ystcdn.venuertc.com/venue/AI/eb3d29ae-43c6-42f5-a0ad-700ec9f7e3ee.jpg","\u003Cdiv class=\"material-main\">\n  \u003Ch2 id=\"material_title\" class=\"material-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">胃癌晚期化疗与靶向用药：全方位安全服药指南\u003C/h2>\n\n  \u003Csection class=\"material-intro material-bg\">\n    \u003Cp>\n      📋在胃癌晚期的治疗过程中，正确选择和使用化疗药及靶向药物是提升治疗效果、降低用药风险的关键。无论是信迪利单抗、奥沙利铂、替吉奥这样的联合化疗方案，还是最新的靶向用药组合，每一种药品都有独特的使用要求和安全注意事项。本篇内容将结合临床经验与权威指南，逐一介绍\u003Cem>7大关键用药细节\u003C/em>，帮助您全面掌握安全服药的实用方法，让每一次用药都科学、有效、安心。\n    \u003C/p>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01 💊化疗与靶向药：成分及剂型简介\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂（Oxaliplatin）：血浆制剂，常用规格为注射剂，每支常见含量为50mg或100mg。主要用于静脉输注。\u003C/li>\n        \u003Cli>替吉奥（Tegafur/Gimeracil/Oteracil）：口服胶囊或片剂型，规格一般以替吉奥成分计，参考包装为15mg、20mg、25mg等。\u003C/li>\n        \u003Cli>信迪利单抗（Sintilimab）：注射用单抗制剂，每瓶常见含量为100mg，用于静脉滴注。\u003C/li>\n      \u003C/ul>\n      \u003Cp>化疗药以静脉注射为主，口服药常见于辅助治疗环节。靶向药物则多为注射给药，需在医院完成。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02 ⏰服药时间与给药方式的关键\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>\u003Cstrong>奥沙利铂与信迪利单抗：\u003C/strong>仅适用于静脉滴注，每次用药确保在医院规范环境下完成，切勿自行注射。\u003C/li>\n        \u003Cli>\u003Cstrong>替吉奥：\u003C/strong>口服给药，餐后30分钟内服用更利于药物吸收，同时可减少胃部不适。喝水量建议≥150ml。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确做法：静脉给药全程留院观察，确认药液输注完毕后再离开。口服片剂时，不要空腹服用，也不要嚼碎胶囊或片剂。\n      \u003C/p>\n      \u003Cp class=\"material-tip\">一位女性患者在联合化疗期间，每次奥沙利铂和信迪利单抗均由护士操作，替吉奥服药则严格遵循餐后半小时，未出现明显胃肠道反应。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03 🔑剂型特点与特殊服用技巧\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂注射液仅用于静脉滴注，溶解后须快速使用，避免因长期暴露而失效。\u003C/li>\n        \u003Cli>替吉奥胶囊/片剂需整粒吞服，不能剥开、碾碎或溶于水，否则药效减弱。\u003C/li>\n        \u003Cli>信迪利单抗为冻干粉针，使用前需完全溶解，无沉淀方可使用。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        特别提醒：如遇胃肠不适，建议口服药服用时间适当调整，确保症状缓解后再服药，但不可擅自停药或更换剂型。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04 🧬作用机制一览（不包含使用方法）\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂：通过形成DNA交联，干扰癌细胞分裂。\u003C/li>\n        \u003Cli>替吉奥：在体内转化为氟尿嘧啶，阻止癌细胞复制。\u003C/li>\n        \u003Cli>信迪利单抗：阻断PD-1，增强免疫细胞对肿瘤细胞的杀伤力。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确理解药物机制有助于理性看待药效与不良反应，合理预期治疗过程。\n      \u003C/p>\n      \u003Cp class=\"material-tip\">文献参考：Sun, J. et al. (2023). Clinical application of PD-1 inhibitor sintilimab in advanced gastric cancer. \u003Cem>Drug Design, Development and Therapy\u003C/em>, 17, 1523-1534.\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05 👥药物相互作用和联合用药注意点\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂、替吉奥可能与抗凝药物（如华法林）发生相互作用，合用时需监测凝血功能。\u003C/li>\n        \u003Cli>信迪利单抗不宜与强烈免疫抑制剂联合使用，否则免疫疗效降低。\u003C/li>\n        \u003Cli>多数化疗药与西咪替丁、雷尼替丁等药物合用，需咨询医生是否影响药效。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确做法：用药期间避免自行添加其他药物，所有联合用药必须由医生评估和开具。\n      \u003C/p>\n      \u003Cp class=\"material-tip\">有位患者在使用替吉奥后合用草药，导致药效波动，后经调整方案，药物血浓度恢复正常。\u003C/p>\n      \u003Cp>\n        跨药品联合应用前，务必报告全部正在服用药品，尤其是中药、抗凝药和免疫类药物。\n      \u003C/p>\n      \u003Cp class=\"material-tip\">文献参考：Xie, Z. et al. (2022). Combined administration of platinum drugs and antacids: risks and recommendations. \u003Cem>Supportive Care in Cancer\u003C/em>, 30(5), 4215-4223.\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06 ⚠️常见不良反应与应对措施\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂：手足麻木、胃肠道不适为常见反应，发生率约30%-50%。\u003C/li>\n        \u003Cli>替吉奥：可能口腔炎、腹泻，严重者偶有白细胞减少，需按医嘱定期监测血象。\u003C/li>\n        \u003Cli>信迪利单抗：可能有皮疹、乏力、发热等，约5%-15%患者发生。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确做法：出现皮疹、口腔溃疡或严重腹泻，应及时反馈医生，切勿自行停药。麻木、疼痛可适当延迟下次用药，具体由医生调整。\n      \u003C/p>\n      \u003Cp class=\"material-tip\">临床数据显示，联合化疗期间不良反应发生率随周期增加，需动态调整剂量。参考：Yoo, C. et al. (2023). Adverse events in advanced gastric cancer therapy: Incidence and management. \u003Cem>J. Gastroenterol.\u003C/em>, 58(2), 220-230.\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07 📦储存方法、有效期与过量处理\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂注射液：密封保存于2-8℃冰箱内，溶液必须于配制后24小时内使用。\u003C/li>\n        \u003Cli>替吉奥片/胶囊：初封产品建议置于室温（15-25℃），避免潮湿与光照，开封后1月内使用。\u003C/li>\n        \u003Cli>信迪利单抗冻干粉：完好包装存储在2-8℃环境，开瓶即用，不可长期储存。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        \u003Cstrong>过量服用\u003C/strong>：\n        化疗药过量风险极高（骨髓抑制等），出现异常症状应\u003Cem>即刻就医\u003C/em>，不可自行处理。漏服后，只有在医生建议下才可补服，切勿自行加倍。\n      \u003C/p>\n      \u003Cp>\n        \u003Cstrong>过期药品\u003C/strong>：\n        严禁继续服用已过有效期药物，过期药应交由医院或药店回收处理，不可随意丢弃。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">08 👩‍⚕️特殊人群用药调整与重点提醒\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>老年人用药：需酌情减少剂量，加强肝肾功能监测。\u003C/li>\n        \u003Cli>孕妇、哺乳期妇女：奥沙利铂、替吉奥、信迪利单抗均不推荐使用，必须充分权衡风险后，由医生决定是否用药。\u003C/li>\n        \u003Cli>肝肾功能不全患者：建议减量或调整间隔周期，具体方案由主治医生制定。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确做法：特殊人群不得自行更改剂量，任何用药调整均须由专业医生审核。\n      \u003C/p>\n      \u003Cp class=\"material-tip\">一例下肢血栓患者在联合化疗期间，抗凝药物由医生全程监控，避免药物相互作用。\u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"material-section material-bg\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">09 📚关键文献与用药数据\u003C/h2>\n    \u003Cdiv class=\"material-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>有效率——替吉奥联合奥沙利铂方案在胃癌治疗中有效率约为40%-60%。\u003Cbr>（参考：Bang, Y.J. et al. (2019). Chemotherapy combinations for advanced gastric cancer: A meta-analysis. \u003Cem>Ann Oncol.\u003C/em> 30(4), 607-617.）\u003C/li>\n        \u003Cli>信迪利单抗相关免疫反应率5%-15%，不良反应多可逆。\u003Cbr>（参考：Sun, J. et al. (2023). Clinical application of PD-1 inhibitor sintilimab in advanced gastric cancer. \u003Cem>Drug Des Dev Ther\u003C/em>, 17, 1523-1534.）\u003C/li>\n        \u003Cli>说明书提示——替吉奥片剂不可嚼碎服用，漏服请勿加量补服。\u003Cbr>（参考：Teysuno，Japanese product information, 2022.\u003C/li>\u003C/ul>\u003C/div>\u003C/section>\n\u003C/div>\n\n\u003Cstyle>\n.material-main {\n  max-width: 850px;\n  margin: 0 auto;\n  font-family: \"Segoe UI\", \"Arial\", sans-serif;\n  background: #f6f9f8;\n  border-radius: 12px;\n  box-shadow: 0 2px 14px 2px rgba(0,46,116,0.08);\n  padding: 24px 28px;\n}\n.material-title {\n  margin-top: 18px;\n  margin-bottom: 26px;\n  font-size: 2.3em;\n  color: #1a436b;\n  font-weight: 700;\n  letter-spacing: 0.02em;\n  text-align: center;\n  border-bottom: 2px solid #bed2e3;\n  padding-bottom: 12px;\n}\n.material-bg {\n  background: linear-gradient(102deg, #e6eff5 8%, #f6f9f8 90%);\n  border-radius: 16px;\n  margin-bottom: 32px;\n  padding: 20px 20px 14px 20px;\n  box-shadow: 0 1px 4px 1px rgba(163,186,231,0.07);\n}\n.material-section {\n  transition: box-shadow 0.2s;\n}\n.material-section:hover {\n  box-shadow: 0 4px 18px 4px rgba(0,46,116,0.09);\n}\n.material-subtitle {\n  font-size: 1.5em;\n  color: #254a7c;\n  margin-bottom: 12px;\n  margin-top: 0;\n  font-weight: 600;\n  display: flex;\n  align-items: center;\n}\n.material-content {\n  font-size: 1.09em;\n  color: #27425a;\n  line-height: 1.74em;\n  margin-bottom: 6px;\n}\n.material-list {\n  margin-left: 0;\n  padding-left: 20px;\n}\n.material-list li {\n  margin-bottom: 11px;\n  line-height: 1.7em;\n}\n.material-tip {\n  background: #f3f7fb;\n  color: #486a90;\n  padding: 9px 13px;\n  border-left: 4px solid #8CC1EA;\n  border-radius: 6px;\n  margin: 13px 0 11px 0;\n  font-size: 1em;\n}\n@media screen and (max-width: 1200px) {\n  .material-main {max-width: 97%;}\n}\n@media screen and (max-width: 900px) {\n  .material-main {padding: 14px 6px;}\n  .material-title {font-size: 1.3em;}\n}\n\u003C/style>\n\n","\u003Cdiv class=\"material-main\">\n  \u003Ch2 id=\"material_title\" class=\"material-title\" style=\"color: rgb(44, 6",523,"2025-09-02 18:22:58","胃癌, 化疗, 靶向用药, 安全服药, 不良反应, 病人指南","本文深入解析胃癌晚期化疗及靶向用药的关键细节，让患者与家属了解用药方法、注意事项与不良反应，确保安全有效治疗。","2025-09-08 11:46:09",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]