[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fSb3p-e7vCYyzBlONciNrLw7287cbzoWttr11DO9-Brk":8,"$fY-YKoMcGkN4C7EFwegGVcVxCnOlkPQskaq_VsFmJC3w":55,"$fCqtNKbw1g2Xgnc81UH2OK_YFN8gHUQDUkrP-o8pZgs8":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},59838,870213,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//hk0nky0jW6hC6kA5kTPwGdSYQ068rXoE.png","俞宁娟","浙江大学医学院附属第二医院","肿瘤科","主治医师",34,0,"直肠癌肝肺转移治疗中的药品安全用药实用指南","","https://ystcdn.venuertc.com/venue/AI/7d501e50-8bb5-46d6-90f0-bd07fe7a14a9.jpg","\u003C!--直肠癌肝肺转移治疗相关药品安全用药指南 BEGIN-->\n\u003Cdiv class=\"meta-drug-wrapper\">\n  \u003Ch2 id=\"material_title\" class=\"meta-drug-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">直肠癌肝肺转移治疗中的药品安全用药实用指南\u003C/h2>\n  \u003Cdiv class=\"meta-drug-intro\">\n    \u003Cp>\n      面对多种药物联合应用的挑战，不少朋友会关心：用在直肠癌肝肺转移治疗中的药品到底怎么用才安全？如化疗药、靶向制剂、口服辅助药物等，各有不同要求。本指南聚焦7个易被忽略但又极其重要的细节，让您正确掌握每种主要药物的使用要点，安心应对日常用药。\n    \u003C/p>\n  \u003C/div>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01 化疗药的服用时间及方法 🕑\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        化疗方案如mFOLFOX6、XELOX、卡培他滨等，是直肠癌肝肺转移常用药物。这些药常需严格按照医嘱给药，部分药品为静脉注射，口服剂型通常要与餐有关。例如，卡培他滨须在餐后半小时内以足量水整片（或整粒）吞服，不能嚼碎，以减少胃肠刺激和增强吸收效果。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">正确做法：\u003C/span>服药要选固定时间，每日两次，早晚餐后半小时服下。遇静脉注射药，应配合专业人员操作且不能自行中断疗程。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">需要注意：\u003C/span>口服药片与热饮同服可能影响稳定性，建议用温开水送服。不可任意更改服药时间。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02 剂型的选择与服用技巧 💊\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        靶向及辅助化疗药（如贝伐珠单抗、阿柏西普、卡培他滨等）有注射、片剂、胶囊型。肠溶片如卡培他滨，禁止掰开或碾碎，以防药效丧失和胃肠刺激。部分药物（如静脉化疗药）对注射速度有要求，过快易引发恶心、骨髓抑制等副反应。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">正确做法：\u003C/span>服用肠溶片要整片吞服，配250ml温水。注射药需由专业人员进行，速度、浓度需严格监控。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03 药物相互作用分析 🔗\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        直肠癌转移治疗常涉及化疗药（如奥沙利铂、伊立替康）、靶向药（如贝伐珠单抗）和中枢辅助药共用。某些药物易与抗凝剂、某些抗生素、质子泵抑制剂等产生相互作用，可能增加出血风险、干扰药效。卡培他滨与华法林共用时，后者抗凝效应可显著增强。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">正确做法：\u003C/span>遇联合用药须主动告知医生当前所有药物列表。两种药被医师要求分开服用时至少间隔2小时。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">需要注意：\u003C/span>自行添加中药、健康补充剂易掩盖相互作用风险，不建议擅自加用。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04 特殊人群的用药调整 👨‍🦳👩‍🦳\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        老年患者、体重过低（如案例患者体重45kg）及肝肾功能减退者，对某些药极为敏感。部分化疗药如伊立替康、奥沙利铂，会因肝脏或肾脏代谢受限而蓄积，加剧副作用。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">正确做法：\u003C/span>化疗期间务必定期复查肝肾功能，必要时调整剂量。肝损害、白细胞下降等副反应，要遵医嘱停药或延长周期。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">特别提醒：\u003C/span>老人用药用量切勿简单按成人标准，儿童及青少年属于特殊禁忌人群，应严格限制绝大部分抗肿瘤药使用。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05 常见不良反应及处理 🚑\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        常见副反应包括恶心呕吐、腹泻、白细胞减少、手足综合征等。奥沙利铂可致感觉异常，贝伐珠单抗有出血、血压升高风险。案例中患者接受多轮化疗后，继续口服卡培他滨，需关注长期毒性。临床数据显示，卡培他滨相关手足综合征发生率可达60%。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">正确做法：\u003C/span>若出现持续呕吐、腹泻、皮肤剥脱等现象需及时就医，酌情延长化疗周期或减量处理。发现注射部位红肿、硬结应报告医护人员。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">需要注意：\u003C/span>中重度骨髓抑制表现时严禁自行继续服药，应至医院复诊。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06 储存方式与有效期 🧊\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        大部分口服药需避光密封、室温保存，部分生物靶向制剂需要2-8℃冷藏，切忌冷冻。开封后二周未用完的药瓶严禁使用。注射类药剂一经配制应当天用完。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">正确做法：\u003C/span>存于干燥阴凉处，远离儿童与宠物。拆封药品切勿与日用品混放。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">需要注意：\u003C/span>过期变色、有潮气味或发霉药品必须全部销毁，千万不可因节省或疏忽继续服用。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07 忘服与过量时的安全对策 🚦\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        遗漏一次口服药怎么办？绝不可一次性加倍补服。大剂量服用易导致毒性蓄积。不少患者因副作用停止服药后自行恢复，有一定风险。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">正确做法：\u003C/span>若单次漏服，发现后及时补服；下次用药不可再加量。如忘记一天以上，建议与医师沟通做进一步调整。\u003Cbr>\n        \u003Cspan class=\"meta-drug-strong\">需要注意：\u003C/span>出现恶心、口腔糜烂、指端麻木等过量中毒迹象，必须立即到正规医疗机构处理，不可等待症状自行缓解。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">08 用药实践案例分享 📝\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cul class=\"meta-drug-case-list\">\n        \u003Cli>一例老年男性，在连续多周期化疗（mFOLFOX6联合卡培他滨）期间出现手足皮肤红肿，经及时告知医师并调整剂量后，不良反应明显减轻。\u003C/li>\n        \u003Cli>临床中发现，联合贝伐珠单抗后若合并非甾体抗炎药，出血风险显著增加，院内已作为用药警示反复培训。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">09 总结与用药警示 ☑️\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Cp>\n        用于直肠癌肝肺转移的药物多为大分子抗肿瘤药、靶向制剂与辅助性药品，相互作用和毒副作用发生风险都高于普通药物。尤其口服抗肿瘤药，必须严格遵医嘱使用。掌握剂型、服用方法、监管异常反应和妥善存储，是减少用药风险的核心。每一次药物调整，建议都要与主诊医生当面沟通后执行。\u003Cbr>\n        化疗药、靶向药联合应用时，更要高度警惕相互作用和不良反应。本指南提到的每一点细节，都是安全用药的重要“守门员”。遵循这些操作，有助于把风险降到最低，实现用药安心、疗效最大化。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003Csection class=\"meta-drug-section\">\n    \u003Ch2 class=\"meta-drug-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">10 文献与权威资料参考\u003C/h2>\n    \u003Cdiv class=\"meta-drug-bg\">\n      \u003Col class=\"meta-drug-reference-list\">\n        \u003Cli>Van Cutsem, E., Cervantes, A., Adam, R., Sobrero, A., Van Krieken, J. H., Aderka, D., ... & Nordlinger, B. (2016). ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. \u003Cem>Annals of Oncology, 27\u003C/em>(8), 1386-1422. https://doi.org/10.1093/annonc/mdw235\u003C/li>\n        \u003Cli>Grothey, A., Sobrero, A. F., Siena, S., Falcone, A., Ychou, M., Humblet, Y., ... & Van Cutsem, E. (2013). Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. \u003Cem>The Lancet, 381\u003C/em>(9863), 303-312. https://doi.org/10.1016/S0140-6736(12)61900-X\u003C/li>\n        \u003Cli>Cremolini, C., Loupakis, F., Antoniotti, C., & Falcone, A. (2020). FOLFOXIRI and Bevacizumab as First-Line Treatment for Metastatic Colorectal Cancer: A Review of the Evidence. \u003Cem>Cancers, 12\u003C/em>(9), 2516. https://doi.org/10.3390/cancers12092516\u003C/li>\n      \u003C/ol>\n    \u003C/div>\n  \u003C/section>\n\u003C/div>\n\n\u003Cstyle>\n.meta-drug-wrapper {\n  font-family: \"PingFang SC\", \"Hiragino Sans GB\", \"Microsoft YaHei\", Arial, sans-serif;\n  background: #fafbfc;\n  padding: 32px 16px 40px 16px;\n  max-width: 850px;\n  margin: 0 auto 40px auto;\n  border-radius: 18px;\n  box-shadow: 0 2px 16px 0 rgba(120,132,153,0.05);\n}\n.meta-drug-title {\n  text-align: center;\n  color: #294375;\n  font-weight: 700;\n  font-size: 2.1em;\n  letter-spacing: .04em;\n  margin-bottom: 32px;\n  line-height: 1.15;\n}\n.meta-drug-intro {\n  background: linear-gradient(90deg, #e3ecfc 0%, #f6fafe 100%);\n  border-radius: 12px;\n  padding: 26px 24px 22px 24px;\n  margin-bottom: 25px;\n  font-size: 1.13em;\n  color: #354060;\n  border-left: 5px solid #80aaff;\n}\n.meta-drug-section {\n  margin-top: 28px;\n  margin-bottom: 30px;\n}\n.meta-drug-subtitle {\n  font-size: 1.22em;\n  font-weight: 600;\n  color: #216ab6;\n  padding-bottom: 10px;\n  letter-spacing: .02em;\n  background: linear-gradient(90deg, #e2ecfa 0%, #f9fbfd 90%);\n  border-radius: 8px 8px 0 0;\n  margin-bottom: 0px;\n  box-shadow: none;\n  padding: 15px 22px 10px 22px;\n}\n.meta-drug-bg {\n  background: linear-gradient(92deg, #f7faff 66%, #e8f0fe 100%);\n  border-radius: 0 0 11px 11px;\n  padding: 22px 32px 16px 28px;\n  font-size: 1.07em;\n  box-sizing: border-box;\n  color: #2f3640;\n  margin-bottom: 0px;\n}\n.meta-drug-bg p, .meta-drug-bg ul, .meta-drug-bg ol {\n  margin: 0;\n  padding: 0;\n}\n.meta-drug-strong {\n  color: #294375;\n  font-weight: bold;\n  margin-right: 5px;\n}\n.meta-drug-case-list {\n  margin-left: 2em;\n  margin-top: 7px;\n  margin-bottom: 7px;\n  color: #39435a;\n  font-size: 1em;\n  line-height: 1.82;\n  list-style: disc;\n}\n.meta-drug-reference-list {\n  color: #313a51;\n  font-size: 1em;\n  margin-left: 2em;\n  line-height: 1.55;\n  margin-top: 7px;\n  padding-right: 10px;\n}\n@media (max-width: 660px) {\n  .meta-drug-wrapper { padding: 8px 1px 26px 1px;}\n  .meta-drug-title { font-size: 1.23em; margin-bottom: 18px;}\n  .meta-drug-section { margin-top: 13px; margin-bottom: 16px;}\n  .meta-drug-subtitle { font-size: 1.13em; padding: 12px 7px 7px 13px;}\n  .meta-drug-bg { padding: 9px 10px 9px 11px; font-size: 0.99em;}\n  .meta-drug-intro { padding: 14px 8px 10px 9px; font-size: 0.98em;}\n  .meta-drug-case-list, .meta-drug-reference-list { font-size: 0.97em;}\n}\n\u003C/style>\n\u003C!--直肠癌肝肺转移治疗相关药品安全用药指南 END-->\n","\u003C!--直肠癌肝肺转移治疗相关药品安全用药指南 BEGIN-->\n\u003Cdiv class=\"meta-drug-wrapper\">\n  \u003Ch2 id=\"material_title\" class=\"me",541,"2025-08-18 10:33:35","直肠癌, 肝肺转移, 药品安全, 化疗药, 靶向药","本指南将帮助您了解直肠癌肝肺转移的药物使用方法和注意事项，确保用药安全与疗效最大化。适用于患者及其家属。","2025-08-21 07:36:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]