[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fGl833bzE293Wqv3YZaoinkA86wJ6fy_Kr4BUoQ72eKE":8,"$fH9ev0PCP12UOGqp7QQJquKMIbDwSlAqn1Wqbt5oGk00":55,"$fyl_8leOh0ULpPoGHc18OgBK9hsJmHreH1pSa0wK4Zf8":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},58648,869215,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//ff00a6mz6WKjPdBvAuW4gk4YL9AAJ8AF.png","康晟","上海市东方医院","心血管内科","主任医师",37,0,"二甲双胍格列吡嗪片实用用药指南：安全用药六大关键点 👨‍⚕️💊","","https://ystcdn.venuertc.com/venue/AI/afa030e7-1f66-4897-b367-951f900459d3.jpg","\u003Cdiv class=\"antidiab-material\">\n  \u003Ch2 id=\"material_title\" class=\"antidiab-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">二甲双胍格列吡嗪片实用用药指南：安全用药六大关键点 👨‍⚕️💊\u003C/h2>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#eef6fa 0%,#f8fafc 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01. 服用时间和正确方法 ⏰\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        二甲双胍格列吡嗪片属于口服降糖药的联合制剂，由二甲双胍和格列吡嗪两种成分复合而成。正确的服药时间与方法，是保障药效、避免副反应的第一步。\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\u003Cstrong>最佳服药时机：\u003C/strong> 该药建议\u003Cstrong>随餐服用\u003C/strong>，餐中或餐后立即服下。这样可以有效减少胃肠道不适，也是预防低血糖的重要手段。\u003C/li>\n        \u003Cli>\u003Cstrong>用水送服：\u003C/strong> 足量温开水吞服整片，避免药片在口中分解，不宜嚼碎或碾碎。\u003C/li>\n        \u003Cli>\u003Cstrong>每天服用次数：\u003C/strong> 按医嘱，常见为每日3次，但应结合医生具体指示，不可自行增减。\u003C/li>\n      \u003C/ul>\n      \u003Cdiv class=\"antidiab-case-box\">\n        \u003Cspan class=\"antidiab-case-point\">案例分享：\u003C/span>\n        有位70岁的患者，每天三餐后各服一次二甲双胍格列吡嗪片，有效控制了晨起后的低血糖风险。\n      \u003C/div>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#f4f7f4 0%,#f8fafc 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02. 剂型特点及用药技巧 💡\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        本品为复合片剂，每片含二甲双胍250mg和格列吡嗪2.5mg。复合制剂的优势在于一日多药一次完成，提高依从性。\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>不建议分拆服用：\u003C/strong> 为确保两种成分比例恒定，\u003Cstrong>务必整片吞服\u003C/strong>。如出现吞咽困难，需与医生沟通换用其它剂型。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>特殊剂型：\u003C/strong> 市场上还有缓释型、控释型等复合制剂，使用方法与普通片剂存在差异，具体请遵循包装说明和医生指导。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>漏服处理：\u003C/strong> 如果偶尔漏服，应尽快补服，但接近下次服药时间时无需补服，也不可一次服用双倍剂量。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#eef6fa 0%,#f8fafc 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03. 药物相互作用与避免误服 🚫\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        二甲双胍和格列吡嗪分别具有独特的代谢途径，但和多类药物存在相互作用，需格外警惕。\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>常见相互作用：\u003C/strong>\n            \u003Cul>\n              \u003Cli>同时使用某些降压药、利尿剂、皮质激素时，可能影响药效。\u003C/li>\n              \u003Cli>含碘造影剂及酒精饮品与本品联用，增加乳酸中毒风险。\u003C/li>\n              \u003Cli>β受体阻滞剂等药品可掩盖低血糖症状，易延误识别。\u003C/li>\n            \u003C/ul>\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>正确做法：\u003C/strong> 用药前向医生咨询所用全部药品和保健品，遇新增处方务必再次核查相互作用。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cdiv class=\"antidiab-case-box\">\n        \u003Cspan class=\"antidiab-case-point\">临床提醒：\u003C/span>\n        有患者在服用该药同时使用某些心血管类药物后，出现药效增强，需及时调整治疗方案。\n      \u003C/div>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#f4f7f4 0%,#f8fafc 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04. 作用机制简析 🔬\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        这类复方药片之所以能有效改善血糖，关键在于两类成分的协同作用，各自机制如下：\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\u003Cstrong>二甲双胍：\u003C/strong> 主要减少肝脏葡萄糖生成，促进组织对糖的利用，改善胰岛素敏感性。不过，它不刺激胰岛素分泌，因此通常不会单独引起低血糖。\u003C/li>\n        \u003Cli>\u003Cstrong>格列吡嗪：\u003C/strong> 促进胰岛β细胞分泌胰岛素，起效快，但也有引发低血糖的可能。\u003C/li>\n        \u003Cli>\n          \u003Cstrong>复合优势：\u003C/strong> 联合制剂既控糖又降低部分低血糖发生风险，有助于优化治疗效果（Rojas, L.B., Gomes, M.B. \"Metformin: an old but still the best treatment for type 2 diabetes.\" Diabetology & Metabolic Syndrome. 2013; 5:6.）。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#eef6fa 0%,#f8fafc 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05. 用药禁忌与注意事项 ⚠️\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        不同人群的用药安全性存在个体差异，有些情况必须回避使用，也有不少细节值得警惕。\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>用药禁忌：\u003C/strong>\n          \u003Cul>\n            \u003Cli>有严重肾功能问题者禁用，肝功能不良也需避免。\u003C/li>\n            \u003Cli>重度感染、缺氧、酗酒时不宜服用。\u003C/li>\n            \u003Cli>孕妇、哺乳期女性和儿童应遵医嘱，部分情况禁用。\u003C/li>\n          \u003C/ul>\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>老年人：\u003C/strong> 年龄超过60岁，特别是基础疾病较多者，建议监测肾功能、遵医嘱调整剂量。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>停药与复诊：\u003C/strong> 如遇手术、重病、特殊检查（如使用造影剂），应事先报备医生是否暂停用药。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cdiv class=\"antidiab-case-box\">\n        \u003Cspan class=\"antidiab-case-point\">特殊提醒：\u003C/span>\n        一位老年患者因肾功能减退需更改药物方案，避免严重不良后果。\n      \u003C/div>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#f4f7f4 0%,#f8fafc 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06. 常见不良反应与处理办法 🚨\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        虽大多数患者耐受良好，但部分人群会遇到一些不适反应。正确识别及应对方法值得提前知晓。\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>常见反应：\u003C/strong> 包括胃肠道不适（如恶心、腹泻）、轻度低血糖症状等。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>处理方法：\u003C/strong>\n          \u003Cul>\n            \u003Cli>如轻微消化不良，建议随餐服用、少量多餐，症状常可自行缓解。\u003C/li>\n            \u003Cli>出现明显低血糖反应，可立即补充含糖食物，再与医生联系调整用量。\u003C/li>\n            \u003Cli>极少数情况（如乳酸性酸中毒表现），一旦精神异常、极度乏力，须立即就医。\u003C/li>\n          \u003C/ul>\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>数据参考：\u003C/strong> 临床研究显示，胃肠道不良反应发生率约为5-20%，低血糖的整体风险低于单用部分促泌剂（UK Prospective Diabetes Study Group. \"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes.\" Lancet. 1998; 352(9131):854-865.）。\n        \u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#eef6fa 0%,#f8fafc 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07. 储存要求与过期处理 📦\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        不同药物对存放环境有特定要求，本品储存方式如下：\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>储存温度：\u003C/strong> 建议保持在25°C以下，放在干燥通风、避光位置。避免将药品随意放置于潮湿浴室、窗台等处。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>药品过期处理：\u003C/strong> 超过保质期药品坚决不可使用，请按医废要求送至药房回收点或由专门机构处理。\u003C/li>\n        \u003Cli>\n          \u003Cstrong>儿童安全：\u003C/strong> 药品务必远离儿童易及之处，防止误服。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section-result\" style=\"background:linear-gradient(90deg,#e8f0fc 0%,#f8fafc 100%); border-left:6px solid #80b6f6; margin-bottom:36px;\">\n    \u003Ch2 class=\"antidiab-summary-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">结语：安全用药，效果佳 👍\u003C/h2>\n    \u003Cdiv class=\"antidiab-content\">\n      \u003Cp>\n        合理应用二甲双胍格列吡嗪片可以发挥双重控糖优势，还能减少单用格列吡嗪的低血糖风险。服用时，务必严格遵照医生建议，注意饮食配合、服药时机以及定期检测肾功能。如果用药过程中有任何不适，要及时与专业医生沟通。每一步都记牢科学用药细节，你的健康管理才真正有保障。\n      \u003C/p>\n      \u003Cul>\n        \u003Cli>\u003Cstrong>千万不可自行增减剂量或换药\u003C/strong>。\u003C/li>\n        \u003Cli>\u003Cstrong>对用药疑问，一定要第一时间咨询专业医生或药师\u003C/strong>。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"antidiab-section\" style=\"background:linear-gradient(90deg,#f8fafc 0%,#e5ecec 100%);\">\n    \u003Ch2 class=\"antidiab-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">参考文献\u003C/h2>\n    \u003Cdiv class=\"antidiab-content antidiab-ref\">\n      \u003Col>\n        \u003Cli>Rojas, L.B., & Gomes, M.B. (2013). Metformin: an old but still the best treatment for type 2 diabetes. \u003Ci>Diabetology & Metabolic Syndrome\u003C/i>, 5:6. \u003Ca href=\"https://diabetolmetabsynd.biomedcentral.com/articles/10.1186/1758-5996-5-6\" target=\"_blank\">链接\u003C/a>\u003C/li>\n        \u003Cli>UK Prospective Diabetes Study (UKPDS) Group. (1998). Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes. \u003Ci>The Lancet\u003C/i>, 352(9131), 854–865. \u003Ca href=\"https://pubmed.ncbi.nlm.nih.gov/9742977/\" target=\"_blank\">链接\u003C/a>\u003C/li>\n        \u003Cli>Bailey, C.J. (2017). Metformin: historical overview. \u003Ci>Diabetologia\u003C/i>, 60(9), 1566-1576. \u003Ca href=\"https://pubmed.ncbi.nlm.nih.gov/28620763/\" target=\"_blank\">链接\u003C/a>\u003C/li>\n      \u003C/ol>\n    \u003C/div>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.antidiab-material {\n  background-color: #fbfbfd;\n  max-width: 840px;\n  margin: 48px auto 32px auto;\n  font-family: 'Segoe UI', 'PingFang SC', Arial, sans-serif;\n  color: #232a35;\n  border-radius: 16px;\n  box-shadow: 0 8px 36px rgba(128,184,246,0.04);\n  padding: 28px 24px 24px 24px;\n  box-sizing: border-box;\n}\n.antidiab-title {\n  font-size: 2.2em;\n  line-height: 1.3;\n  color: #2897ca;\n  font-weight: bold;\n  padding-bottom: 22px;\n  border-bottom: 2px solid #e3eefb;\n  margin-bottom: 36px;\n}\n.antidiab-section {\n  margin-bottom: 36px;\n  border-radius: 10px;\n  padding: 26px 30px 16px 30px;\n}\n.antidiab-subtitle {\n  font-size: 1.25em;\n  color: #258294;\n  padding-bottom: 10px;\n  margin-bottom: 10px;\n  letter-spacing: 1px;\n  font-weight: bold;\n  background: none;\n}\n.antidiab-content {\n  font-size: 1.05em;\n  color: #314052;\n  line-height: 1.8;\n}\n.antidiab-content ul {\n  margin: 14px 0 14px 24px;\n  padding-left:10px;\n}\n.antidiab-content li {\n  margin-bottom: 7px;\n}\n.antidiab-case-box {\n  background: #f6f9fb;\n  border-left: 5px solid #78bdf1;\n  border-radius: 0 7px 7px 0;\n  padding: 12px 16px 12px 18px;\n  font-size: 1em;\n  margin-top: 16px;\n  box-sizing: border-box;\n  color: #1a4761;\n}\n.antidiab-case-point {\n  font-weight:bold;\n  color: #3094b5;\n}\n.antidiab-summary-title {\n  font-size: 1.15em;\n  color: #237baa;\n  font-weight: bold;\n  margin-bottom: 10px;\n}\n.antidiab-section-result {\n  padding:28px 30px 12px 30px;\n  border-radius: 12px;\n  margin-bottom: 32px;\n}\n.antidiab-ref {\n  font-size:0.96em;\n  color: #60748b;\n}\n.antidiab-ref ol {\n  padding-left: 21px;\n  margin-top:14px;\n}\n.antidiab-ref li {\n  margin-bottom: 5px;\n  word-break: break-all;\n}\n@media (max-width:700px) {\n  .antidiab-material {\n    padding: 14px 3% 8px 3%;\n    border-radius: 0;\n    max-width:98vw;\n  }\n  .antidiab-section, .antidiab-section-result {\n    padding: 14px 2% 8px 2%;\n    border-radius: 0;\n  }\n  .antidiab-title {\n    font-size: 1.4em;\n    padding-bottom: 13px;\n    margin-bottom: 24px;\n  }\n}\n\u003C/style>\n\n","\u003Cdiv class=\"antidiab-material\">\n  \u003Ch2 id=\"material_title\" class=\"antidiab-title\" style=\"color: rgb(4",576,"2025-08-13 10:09:44","二甲双胍, 格列吡嗪, 口服降糖药, 糖尿病用药, 安全用药, 药物相互作用, 不良反应, 用药禁忌, 低血糖, 降糖药物","了解二甲双胍格列吡嗪片的正确用法、药物相互作用与不良反应，确保安全用药，改善血糖控制。适合糖尿病患者和其家属。","2025-08-21 08:34:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","慢性病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]