[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fuzDfFi3MoR1hpYoAS04am6BDxt7ZsIZ7e_zuJqnO4vQ":8,"$fJfiRE4Crp_2onUl_FpUcz2UALpFGK0uqcCwg7CTSDdA":55,"$fUCrB0zUpORUqQNOPtVJqY2w5o0aXSTx5_isuEro1Od0":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},57270,868930,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//I1FWmnRcbiiMwqwaoazidCwMZV08s7iU.png","费正华","温州医科大学附属第一医院","肿瘤科","副主任医师",16,0,"胃腺癌伴脑转移常用药品实用用药指南","","https://ystcdn.venuertc.com/venue/AI/f2eb6165-c3cc-48b0-aaa2-413f9a257010.jpg","\u003Cdiv class=\"material-container\">\n  \u003Ch2 id=\"material_title\" class=\"material-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">胃腺癌伴脑转移常用药品实用用药指南\u003C/h2>\n\n  \u003Cdiv class=\"material-section material-bg1\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🌟 一、导语：化疗与支持药物，细节决定安全\u003C/h2>\n    \u003Cp class=\"material-text\">\n      说起来，针对复杂肿瘤治疗我们常会用到替吉奥、奥沙利铂这类化疗药物，以及地塞米松、昂丹司琼等辅助用药。每一类药品都有各自的服用技巧、相互作用和不良反应。下面就以实际用药为例，一次性讲清这些药品在家庭和住院中的7个关键细节——只聚焦药品本身，方便大家参考与记忆。\n    \u003C/p>\n  \u003C/div>\n\n  \u003C!-- 01 -->\n  \u003Cdiv class=\"material-section material-bg2\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">1️⃣ 服药时间与方法全解析\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        \u003Cstrong>替吉奥胶囊（Tegafur-Gimeracil-Oteracil Capsules）\u003C/strong>：用量通常由医生根据体表面积和肝肾功能调整。\u003Cbr>\n        \u003Cspan class=\"material-important\">正确做法：\u003C/span>一般建议早晚各一次，餐后30分钟内整粒用水吞服，切勿咬碎或掰开。漏服时，不得一次补服两倍剂量。\u003Cbr>\n        \u003Cspan class=\"material-tips\">特别提醒：\u003C/span>同时进餐能减少刺激胃部的不适感，有助于稳定药效。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>奥沙利铂（Oxaliplatin）\u003C/strong>：为静脉注射用药，由专业医疗人员操作。\u003Cbr>\n        \u003Cspan class=\"material-important\">正确做法：\u003C/span>静脉点滴时浓度与速度严格遵医嘱，一般不与其他药品同瓶输注，避免进食冷饮或接触冷物以减少神经反应。\u003C/li>\n      \u003Cli>\n        \u003Cstrong>地塞米松（Dexamethasone）\u003C/strong>：根据方案口服或注射。\u003Cbr>\n        \u003Cspan class=\"material-important\">服药时机：\u003C/span>清晨口服为佳，预防影响睡眠，并建议足量饮水以免胃黏膜不适。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>昂丹司琼片（Ondansetron Tablets）\u003C/strong>：多用于化疗期间防止恶心呕吐。\u003Cbr>\n        \u003Cspan class=\"material-important\">服法指导：\u003C/span>服前后至少间隔半小时内不暴饮暴食，建议用温水整片吞服。\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\n  \u003C!-- 02 -->\n  \u003Cdiv class=\"material-section material-bg3\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">2️⃣ 剂型特点和易混误区\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        \u003Cstrong>替吉奥胶囊：\u003C/strong>必须整粒吞服，内容物若接触空气易降解，开胶囊服用会降低疗效，且有刺激性。\u003Cbr>\n        \u003Cspan class=\"material-tips\">临床案例：\u003C/span>有位患者咀嚼胶囊后出现口腔黏膜反应，仅单次即可产生局部损伤。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>奥沙利铂：\u003C/strong>需严格配制浓度且配合特定溶液，用葡萄糖注射液溶解。常用规格50mg与100mg。\u003Cbr>\n        \u003Cspan class=\"material-important\">特别提醒：\u003C/span>禁止与氯化钠溶液混合，否则易出现析出。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>地塞米松片：\u003C/strong>属于糖皮质激素片剂，服用时应一次性吞服，无需掰碎。\u003Cbr>\n        \u003Cspan class=\"material-tips\">需要注意：\u003C/span>长期服用需遵医嘱逐步减量，不可自行停药。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>昂丹司琼片：\u003C/strong>为抗呕吐药水溶性片剂，禁止嚼服或碾碎，否则吸收速度改变，药效不稳定。\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\n  \u003C!-- 03 -->\n  \u003Cdiv class=\"material-section material-bg4\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">3️⃣ 常见药物相互作用注意事项\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        \u003Cstrong>替吉奥胶囊：\u003C/strong>与华法林、苯妥英钠并用时（如合用抗凝/抗癫痫），会增强毒性或改变血药浓度。\u003Cbr>\n        \u003Cspan class=\"material-important\">正确做法：\u003C/span>合用前后务必监测凝血指标或药血浓度，严禁自行加减药。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>奥沙利铂：\u003C/strong>与氨基糖苷类等肾毒药物合用时，肾损害风险增高。不可与含铝、铂等制剂同用。\u003Cbr>\n        \u003Cspan class=\"material-tips\">特别提醒：\u003C/span>治疗间隔期间避免补充高剂量维生素C，因其可能影响药效稳定性。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>地塞米松：\u003C/strong>同时使用非甾体抗炎药时（如布洛芬、阿司匹林），胃肠道不良反应率升高。\u003Cbr>\n        \u003Cspan class=\"material-important\">建议：\u003C/span>如必需合用，缩短疗程并注意胃部保护。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>昂丹司琼片：\u003C/strong>与抗心律失常药同用时可增加心律失常风险；与其他5-HT\u003Csub>3\u003C/sub>拮抗剂合用需警惕过量。\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\n  \u003C!-- 04 -->\n  \u003Cdiv class=\"material-section material-bg5\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">4️⃣ 特殊人群用药要点\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        \u003Cstrong>老年人：\u003C/strong>由于肝肾功能退化，替吉奥、奥沙利铂等需适当减量，严密监测血液学指标。\u003Cbr>\n        \u003Cspan class=\"material-tips\">案例：\u003C/span>一位74岁患者入院期间经评估，降低替吉奥剂量后副反应明显减少。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>肝肾功能不全者：\u003C/strong>替吉奥、奥沙利铂均需据检查结果严格调整剂量，因代谢产物蓄积风险升高。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>孕妇哺乳期：\u003C/strong>所有化疗类药物，包括替吉奥和奥沙利铂，孕妇及哺乳期禁用；地塞米松、昂丹司琼用药前需医生权衡利弊。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>儿童：\u003C/strong>这几类药物在儿童中的应用有限，必须依照专业医嘱严格权衡并个体化调整。\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\n  \u003C!-- 05 -->\n  \u003Cdiv class=\"material-section material-bg6\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">5️⃣ 典型不良反应及处理建议\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        \u003Cstrong>替吉奥胶囊：\u003C/strong>最常见为胃肠道反应（如恶心、腹泻）、手足综合征。\u003Cbr>\n        \u003Cspan class=\"material-data\">数据：\u003C/span>临床研究显示，替吉奥引发的3级以上不良反应发生率在15%-25%之间\u003Csup>[1]\u003C/sup>。出现严重腹泻或皮肤反应，需马上停药并及时联系医生。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>奥沙利铂：\u003C/strong>周围神经病变常见，表现为手足刺痛，对冷敏感。\u003Cbr>\n        \u003Cspan class=\"material-tips\">正确处理：\u003C/span>感觉异常时避免触碰冷物。发生持续性麻木、呼吸困难时，需立即就医处理。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>地塞米松：\u003C/strong>长期大剂量用药可引起高血压、高血糖、骨质疏松。\u003Cbr>\n        \u003Cspan class=\"material-important\">正确应对：\u003C/span>定期监测血压、血糖及骨密度。突然停药会造成急性肾上腺危象，务必遵医嘱逐渐减量。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>昂丹司琼片：\u003C/strong>可出现头痛、便秘或轻度心律异常。\u003Cbr>\n        \u003Cspan class=\"material-important\">警惕：\u003C/span>如伴持续性头晕、心悸，需停药并咨询医生。\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\n  \u003C!-- 06 -->\n  \u003Cdiv class=\"material-section material-bg7\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">6️⃣ 储存条件与有效期指南\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        \u003Cstrong>替吉奥胶囊：\u003C/strong>放置于干燥处，常温储存（不超过25°C），避免日晒潮湿，开瓶后一个月用完为宜。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>奥沙利铂：\u003C/strong>原药瓶密封避光储存。配好静脉液后，需4小时内用完，不适宜保存。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>地塞米松片：\u003C/strong>常温储存，密封防潮。开封后注意避免孩子误食。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>昂丹司琼片：\u003C/strong>阴凉干燥处保存（温度低于30℃），保持包装完好，切勿置于潮湿环境中。\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\n  \u003C!-- 07 -->\n  \u003Cdiv class=\"material-section material-bg8\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">7️⃣ 漏服与过量的正确补救\u003C/h2>\n    \u003Cul class=\"material-list\">\n      \u003Cli>\n        \u003Cstrong>替吉奥胶囊：\u003C/strong>漏服时，应在下一次正常时间继续服用，无需补服或加量。\u003Cbr>\n        \u003Cspan class=\"material-important\">如一次误服过量：\u003C/span>密切观察，及时联系医生，必要时送医。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>奥沙利铂：\u003C/strong>为静脉注射药物，发生过量时需在医院监护，由专业医生处理。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>地塞米松、昂丹司琼：\u003C/strong>服药过量可引发不良反应，及时停药，携带用药记录前往医院检查。\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\n  \u003C!-- 结尾 -->\n  \u003Cdiv class=\"material-section material-conclusion\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🔍 总结&用药建议\u003C/h2>\n    \u003Cp class=\"material-text\">\n      \u003Cspan class=\"material-strong-highlight\">整体来看，\u003C/span>替吉奥、奥沙利铂、地塞米松、昂丹司琼等药品安全应用需关注剂量准确、用药时间、相互作用、不良反应的处理和储存条件。\u003Cbr>\n      建议务必根据医生指导定期复查、合理用药。\u003Cbr>\n      把握细节，减少风险，让药品在治疗中发挥最大价值。如有特殊情况或疑问，及时与医生、药师沟通。\n    \u003C/p>\n  \u003C/div>\n\n  \u003C!-- 参考文献 -->\n  \u003Cdiv class=\"material-section material-bg9\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">📚 参考文献\u003C/h2>\n    \u003Col class=\"material-refs\">\n      \u003Cli>\n        Shirasaka, T., Nakano, K., Takechi, T., Satake, H., Uchida, J., Fujioka, A., ... & Fukushima, M. (1996). Antitumor activity of an oral fluoropyrimidine derivative, S-1 (Tegafur-Gimeracil-Oteracil potassium), against human gastric cancer. \u003Ci>British Journal of Cancer, 74\u003C/i>(3), 454–459.\n      \u003C/li>\n      \u003Cli>\n        Cassidy, J., Misset, J. L., & Diaz-Rubio, E. (2000). Oxaliplatin-based combination therapy for advanced colorectal cancer: A review of efficacy and safety. \u003Ci>Annals of Oncology, 11\u003C/i>(8), 939–956.\n      \u003C/li>\n      \u003Cli>\n        Navari, R. M., & Aapro, M. (2016). Antiemetic prophylaxis for chemotherapy-induced nausea and vomiting. \u003Ci>New England Journal of Medicine, 374\u003C/i>(14), 1356–1367.\n      \u003C/li>\n      \u003Cli>\n        Schäcke, H., Döcke, W. D., & Asadullah, K. (2002). Mechanisms involved in the side effects of glucocorticoids. \u003Ci>Pharmacology & Therapeutics, 96\u003C/i>(1), 23–43.\n      \u003C/li>\n    \u003C/ol>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.material-container {\n  max-width: 820px;\n  margin: 32px auto 24px auto;\n  background: #fafbfb;\n  border-radius: 8px;\n  box-shadow: 0 4px 24px rgba(75,155,182,0.11), 0 1.5px 5px rgba(110,168,195,0.09);\n  font-family: 'Segoe UI', 'Arial', sans-serif;\n  font-size: 18px;\n  color: #243746;\n  padding: 36px 32px 32px 32px;\n}\n.material-title {\n  font-size: 2.4em;\n  font-weight: bold;\n  text-align: center;\n  margin: 0 0 24px 0;\n  letter-spacing: 1.8px;\n  color: #205580;\n  line-height: 1.24;\n}\n.material-section {\n  margin-top: 34px;\n  margin-bottom: 22px;\n  padding: 28px 24px 20px 24px;\n  border-radius: 12px;\n}\n.material-bg1 {\n  background: linear-gradient(100deg, #eef4fa 90%, #d9ebe3 140%);\n}\n.material-bg2 {\n  background: linear-gradient(90deg, #deebf7 80%, #e8f1ef 120%);\n}\n.material-bg3 {\n  background: linear-gradient(90deg, #f6efed 80%, #eaeaee 130%);\n}\n.material-bg4 {\n  background: linear-gradient(95deg, #e6f6ee 80%, #dbf1fa 130%);\n}\n.material-bg5 {\n  background: linear-gradient(92deg, #f3f6ea 75%, #e2e6ef 130%);\n}\n.material-bg6 {\n  background: linear-gradient(95deg, #ecf1fa 70%, #e6f9f1 130%);\n}\n.material-bg7 {\n  background: linear-gradient(96deg, #f9f5ef 80%, #eaf4f4 140%);\n}\n.material-bg8 {\n  background: linear-gradient(99deg, #eaf7ff 65%, #fdebe3 135%);\n}\n.material-bg9 {\n  background: linear-gradient(99deg, #f2fdf9 85%, #eef3f8 120%);\n}\n.material-conclusion {\n  background: linear-gradient(90deg, #ffd9eb 60%, #f7f7f7 160%);\n  margin-bottom: 24px;\n}\n.material-subtitle {\n  font-size: 1.48em;\n  font-weight: 600;\n  color: #276177;\n  margin-bottom: 18px;\n  margin-top: 0;\n  letter-spacing: 1.2px;\n  text-shadow: 0 2px 18px rgba(181, 196, 225, 0.07);\n}\n.material-list {\n  margin: 0;\n  padding: 0 0 0 18px;\n}\n.material-list li {\n  margin-bottom: 15px;\n  line-height: 1.8;\n  list-style-type: disc;\n}\n.material-important {\n  color: #c44343;\n  font-weight: 520;\n  margin-left: 2px;\n}\n.material-tips {\n  color: #5b9e31;\n  font-weight: 480;\n  margin-left: 2px;\n}\n.material-data {\n  background: #f6ffed;\n  border-radius: 5px;\n  color: #206d6a;\n  padding: 1px 8px;\n  margin-right: 3px;\n  font-size: 0.98em;\n  display: inline-block;\n}\n.material-strong-highlight {\n  font-weight: bold;\n  color: #1b798e;\n}\n.material-text {\n  margin: 12px 0 0 0;\n  font-size: 1.05em;\n  line-height: 1.78;\n}\n.material-refs {\n  padding-left: 24px;\n  font-size: 1em;\n  color: #4b6582;\n}\n.material-refs li {\n  margin-bottom: 7px;\n  list-style-type: decimal;\n}\n@media (max-width: 700px) {\n  .material-container {\n    padding: 16px 10px;\n  }\n  .material-section {\n    padding: 15px 5px 14px 10px;\n    margin-top: 18px;\n    margin-bottom: 13px;\n  }\n  .material-title {\n    font-size: 1.4em;\n    padding: 0 3px;\n  }\n  .material-subtitle {\n    font-size: 1.1em;\n    padding-left: 0;\n  }\n}\n\u003C/style>\n\n","\u003Cdiv class=\"material-container\">\n  \u003Ch2 id=\"material_title\" class=\"material-title\" style=\"color: rgb(",545,"2025-08-08 15:57:39","胃腺癌, 替吉奥, 奥沙利铂, 化疗药物, 用药指南, 不良反应, 服药方法","该指南提供了胃腺癌伴脑转移患者常用药品（如替吉奥、奥沙利铂等）的服用方法及注意事项，帮助患者安全用药，减轻不良反应，实现最佳治疗效果。","2025-08-10 07:54:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]