[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fagUfjYFdwlNZttQ7aqeSz4DLtk2pAvtXBQLM07L2ei0":8,"$faATHGqj9k60BaCBwwy50c1vrQkLEBcgaiGakV7EyAdo":55,"$fBPzkWn8c_KGipIGQBiUOUkpB7yBKSkfcXaxiyQG3AVs":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},56062,870358,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//KGvUiQyxX7cgFOiNjW883bSOhp4xZi3T.png","罗旭","大连医科大学附属第一医院","肝胆外科","住院医师",53,0,"结直肠癌复发转移常用药品安全用药全攻略","","https://ystcdn.venuertc.com/venue/AI/0a350050-1cd1-4d2a-a47a-43937095e70a.jpg","\u003Cdiv class=\"guide-wrap\">\n  \u003Ch2 id=\"material_title\" class=\"guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">结直肠癌复发转移常用药品安全用药全攻略\u003C/h2>\n  \n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(90deg,#f7f7fa 60%,#e6ecf7 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01 主要药品类别与基础作用 🤔\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Cp>在结直肠癌复发转移的治疗中，目前应用最多的药品大致分为三类：\u003Cb>化疗药物、靶向药物、抗感染药物\u003C/b>。化疗药如伊立替康（Irinotecan）、奥沙利铂（Oxaliplatin）、氟尿嘧啶（5-FU）是基础用药；靶向药如瑞戈非尼（Regorafenib）等则针对肿瘤细胞相关信号通路；术后或特殊并发症时还会用到万古霉素（Vancomycin）等抗生素。\u003Cbr>\n      本文将分别介绍这些药品的成分、剂型、使用要点及重要注意事项，帮助大家安全用药，避免风险。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(100deg,#e8f5e9 50%,#f1f8e9 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02 化疗药物安全用药细节 🔬\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">常用化疗药成分与剂型\u003C/h3>\n      \u003Cp>\n        - \u003Cb>伊立替康\u003C/b>（Irinotecan）：静脉注射制剂，属于拓扑异构酶Ⅰ抑制剂。\u003Cbr>\n        - \u003Cb>奥沙利铂\u003C/b>（Oxaliplatin）：静脉注射制剂，铂类化合物。\u003Cbr>\n        - \u003Cb>氟尿嘧啶\u003C/b>（5-FU）：有静脉注射、口服（卡培他滨）等多种形式。\n      \u003C/p>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">药理作用重点\u003C/h3>\n      \u003Cul>\n        \u003Cli>\u003Cb>伊立替康\u003C/b>：干扰DNA复制，阻止肿瘤细胞分裂。\u003C/li>\n        \u003Cli>\u003Cb>奥沙利铂\u003C/b>：与DNA结合，抑制其修复和复制。\u003C/li>\n        \u003Cli>\u003Cb>5-FU\u003C/b>：阻断DNA和RNA合成。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">正确使用方法\u003C/h3>\n      \u003Cul>\n        \u003Cli>\u003Cb>剂型选择：\u003C/b>化疗药绝大多数为静脉滴注，用药需在专业医疗条件下进行。\u003C/li>\n        \u003Cli>\u003Cb>用药周期：\u003C/b>一般按多周期方案，每周期间隔2-3周，具体须遵医嘱，不可自行变更。\u003C/li>\n        \u003Cli>\u003Cb>饮食关系：\u003C/b>注射时无需空腹，也无需特殊饮食准备，但口服药如卡培他滨建议饭后服用以减轻胃肠刺激。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">特殊操作技巧\u003C/h3>\n      \u003Cul>\n        \u003Cli>\u003Cb>静脉注射：\u003C/b>必须由专业护理人员操作，不可自行注射。\u003C/li>\n        \u003Cli>\u003Cb>口服化疗药：\u003C/b>整片吞服，不要咀嚼、掰开或研碎。\u003C/li>\n        \u003Cli>\u003Cb>补水：\u003C/b>化疗期间需保持充足饮水，帮助代谢药物。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">用药小案例\u003C/h3>\n      \u003Cp>曾有一位66岁女性患者在用FOLFIRI方案（伊立替康+5-FU+亚叶酸钙）时因腹泻而减量，提醒大家多留意不良反应，及时与医生沟通调整方案。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(85deg,#f9fbe7 80%,#e1f5fe 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03 靶向药物安全用药指引🌱\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">主流成分与剂型\u003C/h3>\n      \u003Cp>\n        - \u003Cb>瑞戈非尼\u003C/b>（Regorafenib）：口服片剂，属于多靶点酪氨酸激酶抑制剂。\u003Cbr>\n        - 其他如贝伐单抗（Bevacizumab）为静脉制剂，更多用于一线方案。\n      \u003C/p>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">作用机制简介\u003C/h3>\n      \u003Cul>\n        \u003Cli>瑞戈非尼通过抑制多条肿瘤生长信号通路，抑制血管新生和肿瘤扩散。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">服用时间与方法\u003C/h3>\n      \u003Cul>\n        \u003Cli>\u003Cb>服药时间：\u003C/b>建议每日固定时间服用，通常餐后服下。\u003C/li>\n        \u003Cli>\u003Cb>服用方式：\u003C/b>整片用温水送服，不可掰开、嚼碎或溶解在水中。\u003C/li>\n        \u003Cli>\u003Cb>饮食建议：\u003C/b>进食低脂饮食可能有利于吸收和安全性。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">剂量调整提醒\u003C/h3>\n      \u003Cul>\n        \u003Cli>如服药后出现严重乏力、食欲下降或腹泻，须及时联系医生，不可擅自停药或自行减量。\u003C/li>\n        \u003Cli>老年患者或肝肾功能不全者，应根据个体情况调整剂量。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">用药案例借鉴\u003C/h3>\n      \u003Cp>在临床上，部分患者使用瑞戈非尼出现乏力和轻度腹泻，医生会酌情减量或暂时停药，并加强饮食及对症处理。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(95deg,#f3e5f5 70%,#e8eaf6 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04 抗感染药物安全使用须知🦠\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">常用成分与剂型\u003C/h3>\n      \u003Cp>\n        - \u003Cb>万古霉素\u003C/b>（Vancomycin）：静脉注射制剂，临床用于严重耐药性细菌感染。\n      \u003C/p>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">作用机理提示\u003C/h3>\n      \u003Cul>\n        \u003Cli>万古霉素主要通过抑制细菌细胞壁的合成发挥抗菌效果。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">正确用法与剂量管理\u003C/h3>\n      \u003Cul>\n        \u003Cli>必须严格按照医嘱控制使用剂量和疗程，避免滥用或漏用。\u003C/li>\n        \u003Cli>给药速度过快易致静脉炎或\"红人综合征\"，应遵循推荐输注速度。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">特殊用药场合\u003C/h3>\n      \u003Cul>\n        \u003Cli>脓胸、术后感染等特殊情况下按需使用，需定期监测肾功能。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">不良反应管理\u003C/h3>\n      \u003Cul>\n        \u003Cli>常见副作用为肾功能损伤、耳鸣、皮疹等。\u003C/li>\n        \u003Cli>发现尿量减少、皮肤瘙痒等应及时报告医生。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(80deg,#fff3e0 70%,#ffe0b2 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05 药物相互作用与同时用药⚠️\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">典型相互作用案例\u003C/h3>\n      \u003Cul>\n        \u003Cli>伊立替康与某些降压药、抗真菌药如酮康唑、保健品可能影响药效或毒性，建议主动向医生说明所有正在使用的药品。\u003C/li>\n        \u003Cli>奥沙利铂合并用过高剂量的维生素C可能影响药物稳定性。\u003C/li>\n        \u003Cli>瑞戈非尼易受酶诱导剂（利福平、苯巴比妥）或强制酸剂影响而降低疗效。\u003C/li>\n        \u003Cli>万古霉素与利尿剂、氨基糖苷类合用时增加肾毒性风险。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">正确做法\u003C/h3>\n      \u003Cul>\n        \u003Cli>同类药物避免重复合用，启新药前反复核查已有用药种类。\u003C/li>\n        \u003Cli>如需合用，务必遵医嘱按时间间隔服用。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">饮食协同\u003C/h3>\n      \u003Cul>\n        \u003Cli>服化疗药与靶向药时尽量保持饮食均衡，避免暴饮暴食或过量高脂食品，少饮酒。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(87deg,#fffde7 60%,#fff8e1 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06 特殊人群用药调整指南 👨‍👩‍👧‍👦\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Cul>\n        \u003Cli>\u003Cb>老年人：\u003C/b>肝肾功能下降易累积药物毒性，常需减量和延长给药间隔。\u003C/li>\n        \u003Cli>\u003Cb>肝肾功能不全：\u003C/b>如伊立替康和万古霉素，需要根据功能检测结果调整剂量。\u003C/li>\n        \u003Cli>\u003Cb>孕妇与哺乳期女性：\u003C/b>化疗药物一般禁用，瑞戈非尼禁用于孕妇和哺乳期。\u003C/li>\n        \u003Cli>\u003Cb>糖尿病患者：\u003C/b>部分药物（如化疗药）可能影响血糖，需密切监测。\u003C/li>\n      \u003C/ul>\n      \u003Cp>正确做法：开始新药治疗前，主动向医生说明家族史、过敏史和身体特殊状况。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(90deg,#e3f2fd 60%,#bbdefb 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07 常见不良反应与应对方法 💊\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">化疗药品常见副作用\u003C/h3>\n      \u003Cul>\n        \u003Cli>消化道异常（如腹泻、恶心）\u003C/li>\n        \u003Cli>乏力、白细胞减少\u003C/li>\n        \u003Cli>手脚麻木、味觉改变（多见于奥沙利铂）\u003C/li>\n        \u003Cli>个别可致脱发\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">靶向药品副作用\u003C/h3>\n      \u003Cul>\n        \u003Cli>口腔溃疡、手足皮炎、腹泻\u003C/li>\n        \u003Cli>高血压、肝酶升高\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">抗感染药不良反应\u003C/h3>\n      \u003Cul>\n        \u003Cli>耳鸣、肾功能下降、注射部位炎症\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">应对策略\u003C/h3>\n      \u003Cul>\n        \u003Cli>及时沟通新发或不适感，与医生商讨调整用药或处理意见。\u003C/li>\n        \u003Cli>出现乏力恶心、皮肤反应等，建议合理休息、调整饮食并加强体力维护。\u003C/li>\n        \u003Cli>任何严重反应（如持续高热、突发出血、过敏）需尽快就医。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n  \n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(90deg,#e0f7fa 75%,#b3e5fc 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">08 储存、补救与过量处理 ⏳\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">药品储存 \u003Cspan style=\"font-size:1em;\">📦\u003C/span>\u003C/h3>\n      \u003Cul>\n        \u003Cli>化疗药和靶向药大多需放在阴凉干燥处，避免阳光直射。\u003C/li>\n        \u003Cli>多数药品应在25°C以下保存，部分静脉用药需按说明冷藏。\u003C/li>\n        \u003Cli>开封后药品须按说明规定时限用完，剩余需交回医院妥善销毁。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">漏服与过量应对\u003C/h3>\n      \u003Cul>\n        \u003Cli>若漏服瑞戈非尼、卡培他滨等口服药，发现后立即补服，时间接近下次服药则跳过不过量服用。\u003C/li>\n        \u003Cli>因故多服、过量或不明数量服用时，应立即寻求医院或急诊协助。\u003C/li>\n        \u003Cli>不建议自行催吐或停药，先稳定自身状态，保留药品包装备查。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"guide-mini-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">药品有效期核查\u003C/h3>\n      \u003Cul>\n        \u003Cli>每次新领药品须仔细核查生产日期和有效期。\u003C/li>\n        \u003Cli>过期、外观异常或有异味的药品应停止使用。\u003C/li>\n        \u003Cli>自行丢弃要防止儿童和宠物误食。\u003C/li>\n      \u003C/ul>\n    \u003C/div>\n  \u003C/div>\n  \n  \u003Cdiv class=\"guide-section\" style=\"background:linear-gradient(90deg,#ede7f6 60%,#e0e0e0 100%);\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">09 药品安全用药要点总结 🌟\u003C/h2>\n    \u003Cdiv class=\"guide-content\">\n      \u003Cul>\n        \u003Cli>药品使用前，一定要核查成分和剂型，掌握正确服用方式。\u003C/li>\n        \u003Cli>合并多种药品时需严格核查相互作用，不随意增减其他药物。\u003C/li>\n        \u003Cli>出现副作用不要慌乱，也不自行乱调，优先与医生联系，遵循专业处理建议。\u003C/li>\n        \u003Cli>药品储存需留心环境条件，剩余药品及时销毁防止误用。\u003C/li>\n        \u003Cli>老年人、肝肾功能异常或孕产妇应特别关注用药剂量和风险。\u003C/li>\n      \u003C/ul>\n      \u003Cp>其实，只要按照说明书和医生指导正确用药，大多数药物是安全有效的。遇到疑问或不适，及时求助专业人员，才是最保险的办法。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n  \n  \u003Cdiv class=\"guide-section\" style=\"background:#f2f2f2;\">\n    \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">参考文献/References\u003C/h2>\n    \u003Col class=\"guide-ref\">\n      \u003Cli>Grothey, A., Sobrero, A. F., Siena, S., et al. (2013). Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. \u003Ci>Lancet\u003C/i>, 381(9863), 303-312. https://doi.org/10.1016/S0140-6736(12)61900-X\u003C/li>\n      \u003Cli>Kwakman, J. J., Vink, G., Vestjens, J. H., et al. (2018). Severe Adverse Events in Patients Treated With Chemotherapy (CAPOX/FOLFOX/FOLFIRI) ± Targeted Therapy for Metastatic Colorectal Cancer: A Population-Based Study. \u003Ci>Drugs - Real World Outcomes\u003C/i>, 5(3), 143-153. https://doi.org/10.1007/s40801-018-0141-4\u003C/li>\n      \u003Cli>Liu, C., Bayer, A., Cosgrove, S., Daum, R., Fridkin, S., Gorwitz, R., et al. (2011). Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children. \u003Ci>Clinical Infectious Diseases\u003C/i>, 52(3), e18-e55. https://doi.org/10.1093/cid/ciq146\u003C/li>\n      \u003Cli>Van Cutsem, E., Cervantes, A., Adam, R., Sobrero, A., Van Krieken, J. H., et al. (2016). ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. \u003Ci>Annals of Oncology\u003C/i>, 27(8), 1386-1422. https://doi.org/10.1093/annonc/mdw235\u003C/li>\n      \u003Cli>De Gramont, A., Figer, A., Seymour, M., et al. (2000). Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. \u003Ci>Journal of Clinical Oncology\u003C/i>, 18(16), 2938–2947. https://doi.org/10.1200/JCO.2000.18.16.2938\u003C/li>\n    \u003C/ol>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.guide-wrap {\n  font-family: \"PingFang SC\", \"Helvetica Neue\", Helvetica, Arial, \"Microsoft YaHei\", sans-serif;\n  font-size: 17px;\n  color: #333;\n  line-height: 1.8;\n  max-width: 900px;\n  margin: 30px auto 50px auto;\n  border-radius: 18px;\n  box-shadow: 0 5px 32px rgba(160,170,200,0.17);\n  background: #ffffff;\n  padding: 35px;\n}\n.guide-title {\n  font-size: 2.4em;\n  color: #273c75;\n  text-align: center;\n  font-weight: bold;\n  letter-spacing: 1.5px;\n  margin-bottom: 32px;\n  margin-top: 0;\n  text-shadow: 1px 2px 10px #f2f3f7;\n}\n.guide-section {\n  margin-bottom: 44px;\n  border-radius: 10px;\n  padding: 35px 32px 28px 32px;\n  box-sizing: border-box;\n}\n.guide-subtitle {\n  font-size: 1.45em;\n  color: #37474f;\n  font-weight: bold;\n  border-left: 6px solid #90caf9;\n  margin-bottom: 20px;\n  margin-top: 0;\n  padding-left: 13px;\n  background-color: rgba(255,255,255,0.18);\n  border-radius: 6px;\n  box-shadow: 0 2px 10px rgba(220,220,220,0.12);\n  line-height: 1.25;\n}\n.guide-content ul {\n  margin: 8px 0px 18px 20px;\n  padding-left: 17px;\n}\n.guide-mini-title {\n  font-size: 1.11em;\n  color: #4376c7;\n  margin-bottom: 9px;\n  font-weight: 600;\n  margin-top: 19px;\n  line-height: 1.37;\n}\n.guide-content p, .guide-content ul, .guide-content ol {\n  margin-top: 0.4em;\n  margin-bottom: 0.55em;\n}\n.guide-content li {\n  margin-bottom: 4px;\n}\n.guide-ref {\n  font-size: 0.97em;\n  color: #616161;\n  padding-left: 15px;\n  margin-top: 17px;\n  line-height: 1.7;\n}\n.guide-ref li {\n  margin-bottom: 7px;\n}\n@media (max-width: 600px) {\n  .guide-wrap { padding: 8px; }\n  .guide-section { padding: 10px 8px 15px 8px; }\n  .guide-title { font-size: 1.25em; }\n}\n\u003C/style>\n","\u003Cdiv class=\"guide-wrap\">\n  \u003Ch2 id=\"material_title\" class=\"guide-title\" style=\"color: rgb(44, 62, 80)",529,"2025-08-06 11:31:18","结直肠癌,化疗药物,靶向药物,抗感染药物,用药安全,药物副作用,老年人用药,药物相互作用","本指南为您提供结直肠癌复发转移常用药物的安全使用要点，涵盖化疗药物、靶向药物、抗感染药物等，助您有效管理治疗过程，确保用药安全。","2025-08-09 12:41:29",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]