[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$f1DlcNX8Fk2r8NdmJST-iLlqx8d5As_HOGNw817t8c0s":8,"$f1pdCORNC2Ykz-BldoRJ1FCd-CuuWUIGsHKMhcq7Cuxs":55,"$fGU8xUB7rYI_2vb0hxWGgZ5UuWCM38O34Q_27JNx_J7E":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},55313,863254,[],"https://ystcdn.venuertc.com/medical/ystApp/Dlmj9URvs7gXdepZpARivDbqwZwkg06p.png","朱永亮","龙口南山养生谷肿瘤医院","放射科","住院医师",397,0,"常用直肠癌晚期 pMMR 治疗药品安全用药指南","","https://ystcdn.venuertc.com/venue/AI/8bf0347b-5c71-4369-bfb7-4e267fd53fdd.jpg","\u003Cdiv class=\"material-outer-container\">\n  \u003Cdiv class=\"material-title-container\">\n    \u003Ch2 id=\"material_title\" class=\"material-main-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">常用直肠癌晚期 pMMR 治疗药品安全用药指南\u003C/h2>\n    \u003Cp class=\"material-intro\">\n      说起直肠癌相关治疗药品，很多药友对奥沙利铂和卡培他滨并不陌生。这些化疗药物在治疗过程中各有特点，但正确用药细节直接关系到效果和安全性。本文梳理了7个关键要点，专为需要或即将使用这些药品的患者和家属准备，帮助你科学用药、远离风险。 \n    \u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#f2f7fc,#e9ecef);\">\n      \u003Cspan class=\"material-section-icon\">💊\u003C/span>\n      \u003Cspan class=\"material-section-title\">01 奥沙利铂与卡培他滨：基本成分与剂型一览\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>\n          \u003Cstrong>奥沙利铂（Oxaliplatin）\u003C/strong>属于铂类抗肿瘤药，常以无色透明液体安瓿瓶形式供静脉注射，常见规格为50mg、100mg/支。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>卡培他滨（Capecitabine）\u003C/strong>为口服氟嘧啶类药物，最常见为薄膜衣片，规格通常为150mg、500mg/片。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        选择合适剂型时应根据医生指导。静脉注射药物需专业人员操作，口服片剂则需注意完整吞服。\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#fff6e5,#f7f3ea);\">\n      \u003Cspan class=\"material-section-icon\">💡\u003C/span>\n      \u003Cspan class=\"material-section-title\">02 药品的作用机制\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>\n          \u003Cb>奥沙利铂\u003C/b>能进入细胞后与DNA结合，抑制其复制和修复，从而阻断肿瘤细胞生长。\n        \u003C/li>\n        \u003Cli>\n          \u003Cb>卡培他滨\u003C/b>进入体内后通过酶转化为5-氟尿嘧啶（5-FU），进而影响DNA和RNA合成，使肿瘤细胞凋亡。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        这种协同作用是晚期直肠癌pMMR状态下化疗方案的重要基础。\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#eafbea,#e0fafa);\">\n      \u003Cspan class=\"material-section-icon\">⏲️\u003C/span>\n      \u003Cspan class=\"material-section-title\">03 正确的服用时间与用法用量\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Ch3 class=\"material-subsubtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">奥沙利铂\u003C/h3>\n      \u003Cul class=\"material-list\">\n        \u003Cli>主要通过静脉滴注给药，通常每2或3周一次，具体剂量由体表面积等因素决定。\u003C/li>\n        \u003Cli>首次注射后需严格监控，有过敏史者应提前告知医护人员。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"material-subsubtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">卡培他滨\u003C/h3>\n      \u003Cul class=\"material-list\">\n        \u003Cli>通常建议餐后30分钟内用温水送服，保证完整吞服不可咀嚼或压碎。\u003C/li>\n        \u003Cli>日服2次（间隔12小时），疗程安排由医生根据效果调整。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确做法：严格按方案执行，不随意增减剂量。如漏服一剂，不可随意补服，应继续按原计划时间服药。\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#fceaea,#f9e3e3);\">\n      \u003Cspan class=\"material-section-icon\">❗\u003C/span>\n      \u003Cspan class=\"material-section-title\">04 药物相互作用与并用禁忌\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂与氨基葡萄糖类药同用可能增神经毒性。\u003C/li>\n        \u003Cli>卡培他滨与华法林并用可增强抗凝血作用，需密切监测凝血相关指标。\u003C/li>\n        \u003Cli>同时服用抗酸药（如铝、镁类）可影响卡培他滨吸收，建议间隔2小时以上。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确做法：用药前将所有正在服用的药物和保健品清晰告知医生或药师。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#f5f7fa,#ece9f9);\">\n      \u003Cspan class=\"material-section-icon\">👵\u003C/span>\n      \u003Cspan class=\"material-section-title\">05 特殊人群用药调整\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>\u003Cstrong>老年人\u003C/strong>：肾功能下降、体重不足者常需调整剂量，部分患者起始剂量可降低；密切监测不良反应。\u003C/li>\n        \u003Cli>\u003Cstrong>肝肾功能不全者\u003C/strong>：奥沙利铂及卡培他滨主要通过肾代谢，肾功能异常时，剂量或用药频率通常要减少。\u003C/li>\n        \u003Cli>\u003Cstrong>孕妇及哺乳期妇女\u003C/strong>：两类药物均有致畸及哺乳禁忌，应严格避用。\u003C/li>\n      \u003C/ul>\n      \u003Cp>正确做法：本类药品必须根据医生处方及监护用药，严禁自行增减剂量。\u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#fafaec,#f4f9ed);\">\n      \u003Cspan class=\"material-section-icon\">⚠️\u003C/span>\n      \u003Cspan class=\"material-section-title\">06 常见不良反应与及时处理\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Ch3 class=\"material-subsubtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">奥沙利铂\u003C/h3>\n      \u003Cul class=\"material-list\">\n        \u003Cli>手脚麻木、刺痛（外周神经病变），常为剂量相关，应避免接触冷水冷物加重症状。\u003C/li>\n        \u003Cli>部分患者可能发生恶心、呕吐，遵医嘱用止吐药可减轻反应。\u003C/li>\n        \u003Cli>偶见严重过敏反应，表现为皮肤红疹、呼吸困难，需立即停药就医。\u003C/li>\n      \u003C/ul>\n      \u003Ch3 class=\"material-subsubtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">卡培他滨\u003C/h3>\n      \u003Cul class=\"material-list\">\n        \u003Cli>常引起手足综合征（皮肤发红、脱皮），可使用保湿用品，严重时需暂停用药。\u003C/li>\n        \u003Cli>腹泻较常见，持续或剧烈腹泻要及时报告医生，避免脱水。\u003C/li>\n        \u003Cli>部分人可能有口腔炎，保持口腔清洁，轻微症状多可自行缓解，严重时暂停服药。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        临床研究显示，奥沙利铂引发手足麻木的发生率约有60%（Gamelin et al., 2004），卡培他滨相关手足综合征发生率在18-60%之间（Blum et al., 2001）。\n      \u003C/p>\n      \u003Cp>\n        正确做法：发现严重不适、皮疹、水肿、呼吸异常或持续呕吐腹泻等，应立即中止本次用药并及时就医，切勿自行处理！\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#e7f5fa,#e5f5ee);\">\n      \u003Cspan class=\"material-section-icon\">📦\u003C/span>\n      \u003Cspan class=\"material-section-title\">07 储存方法与过期药物管理\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂针剂需避光、避热冷藏（2-8℃)，用前取出恢复室温再配制，不可直接暴露于高温。\u003C/li>\n        \u003Cli>卡培他滨片剂置阴凉干燥处保存，避免受潮及强光照射。\u003C/li>\n        \u003Cli>开封后及时用完，过期或变色药品切勿再使用，务必按照药店指导或社区药品回收渠道安全处理。\u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        正确做法：储存位置需远离儿童和宠物，防止误服。\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#fbeacb,#f6e9ec);\">\n      \u003Cspan class=\"material-section-icon\">🤔\u003C/span>\n      \u003Cspan class=\"material-section-title\">08 漏服与过量处理\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>\n          \u003Cb>卡培他滨\u003C/b>如漏服，不可补服或加量，按下次正常时间服用即可。如误服超量，应尽快通知医生，特别关注是否有明显不良反应。\n        \u003C/li>\n        \u003Cli>\n          \u003Cb>奥沙利铂\u003C/b>静脉给药需专业监护，出现配药或用药剂量问题应及时报告医护团队。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        出现用药差错时，不建议自行处理，应第一时间求助专业医疗团队。\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#eaf4fc,#f3ecfa);\">\n      \u003Cspan class=\"material-section-icon\">📑\u003C/span>\n      \u003Cspan class=\"material-section-title\">09 典型用药经验分享\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul class=\"material-list\">\n        \u003Cli>\n          有位患者使用奥沙利铂期间发生麻木，在提醒后避免冷饮刺激，症状明显减轻。\n        \u003C/li>\n        \u003Cli>\n          一位老年患者服用卡培他滨后出现轻度手足肿胀，及时联系医生后调整剂量，顺利完成疗程。\n        \u003C/li>\n        \u003Cli>\n          临床上发现卡培他滨漏服时按规定不补服，安全性更有保障。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        这些经验说明，留意用药反应，及时与医生沟通，是安全合理用药的关键。\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#e4fbfb,#f6f7fa);\">\n      \u003Cspan class=\"material-section-icon\">🔑\u003C/span>\n      \u003Cspan class=\"material-section-title\">10 全文要点总结与实用提醒\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cp>\n        化疗药物如奥沙利铂和卡培他滨在直肠癌pMMR患者治疗中应用广泛，但合理、安全用药极其重要。正确的服药时间、方法和剂量，预防不良反应，了解药品相互作用及储存方法，是每位患者都需要掌握的基本功。遇到异常反应或无法判断的情况，第一时间请教医生或药师，切勿自行调整药物。用药，是一场需要耐心和专业配合的\"马拉松\"，唯有科学管理，才能保障最大获益、最小风险。\n      \u003C/p>\n      \u003Cp>\n        \u003Cb>再次强调：\u003C/b>所有化疗药品均需在指导下安全使用，明确每一步细节都是安全用药的重要保障。\n      \u003C/p>\n    \u003C/div>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section\">\n    \u003Cdiv class=\"material-section-header\" style=\"background: linear-gradient(90deg,#ebf2fc,#f7f3ed);\">\n      \u003Cspan class=\"material-section-icon\">🔬\u003C/span>\n      \u003Cspan class=\"material-section-title\">参考文献\u003C/span>\n    \u003C/div>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Col class=\"material-ref-list\">\n        \u003Cli>Gamelin, L., Boisdron-Celle, M., Morel, A., Poirier, A.-L., Kerbrat, P., & Gamelin, E. (2004). Oxaliplatin-related neurotoxicity: interest and limits of neuroprotective strategies. \u003Ci>Supportive Care in Cancer\u003C/i>, 12(8), 571–581. https://doi.org/10.1007/s00520-004-0619-0\u003C/li>\n        \u003Cli>Blum, J. L., Jones, S. E., Buzdar, A. U., LoRusso, P. M., Kuter, I., Vogel, C., ... & Reich, L. (2001). Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer. \u003Ci>Journal of Clinical Oncology\u003C/i>, 19(22), 4097–4106. https://doi.org/10.1200/JCO.2001.19.22.4097\u003C/li>\n        \u003Cli>Twelves, C., Wong, A., Nowacki, M. P., Abt, M., Burris, H., Carrato, A., ... & Van Cutsem, E. (2005). Capecitabine as adjuvant treatment for stage III colon cancer. \u003Ci>New England Journal of Medicine\u003C/i>, 352(26), 2696-2704. https://doi.org/10.1056/NEJMoa043116\u003C/li>\n        \u003Cli>Saif, M. W., & Reardon, J. (2005). Management of oxaliplatin-induced peripheral neuropathy. \u003Ci>Therapy\u003C/i>, 2(4), 389-393. https://doi.org/10.2217/14750708.2.4.389\u003C/li>\n      \u003C/ol>\n    \u003C/div>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.material-outer-container {\n  max-width: 840px;\n  background: #fff;\n  margin: 38px auto 38px auto;\n  border-radius: 18px;\n  box-shadow: 0 3px 34px rgba(42,63,104,0.07);\n  padding: 30px 28px 42px 28px;\n  font-family: 'Segoe UI', 'PingFang SC', 'Hiragino Sans GB', 'Arial', sans-serif;\n}\n.material-title-container {\n  border-bottom: 2px solid #e3ebf7;\n  margin-bottom: 16px;\n  padding-bottom: 6px;\n}\n.material-main-title {\n  font-size: 2.0em;\n  color: #212f42;\n  line-height: 1.25;\n  font-weight: 700;\n  margin: 0 0 12px 0;\n}\n.material-intro {\n  color: #376b81;\n  font-size: 1.18em;\n  margin: 0 0 5px 0;\n}\n.material-section {\n  margin-bottom: 30px;\n  margin-top: 8px;\n}\n.material-section-header {\n  display: flex;\n  align-items: center;\n  border-radius: 12px 12px 0 0;\n  min-height: 44px;\n  padding: 0 18px;\n  font-size: 1.11em;\n  font-weight: bold;\n  color: #1d2345;\n  border-left: 4px solid #79c7cc;\n  border-bottom: 1px solid #e6e8eb;\n  letter-spacing: .02em;\n}\n.material-section-icon {\n  margin-right: 11px;\n  font-size: 1.3em;\n}\n.material-section-title {\n  font-weight: 600;\n  flex: 1;\n}\n.material-section-content {\n  background: #f9fbfc;\n  padding: 18px 22px 12px 22px;\n  font-size: 1.02em;\n  line-height: 1.86;\n  color: #273348;\n  border-radius: 0 0 12px 12px;\n  border: 1px solid #eef3f8;\n  border-top: none;\n  margin-bottom: 4px;\n  min-height: 45px;\n}\n.material-list {\n  margin: 6px 0 13px 0;\n  padding-left: 22px;\n}\n.material-list li {\n  margin-bottom: 7px;\n}\n.material-subsubtitle {\n  color: #657590;\n  font-size: 1.03em;\n  font-weight: 560;\n  margin-top: 9px;\n  margin-bottom:1px;\n}\n.material-ref-list {\n  margin: 10px 0 0 16px;\n  padding: 0 0 0 10px;\n  font-size: 0.98em;\n  color: #5f697d;\n  line-height: 1.75;\n}\n.material-ref-list li {\n  margin-bottom: 7px;\n}\n@media (max-width:700px) {\n  .material-outer-container { padding:10px 2vw 10px 2vw; max-width:99vw; }\n  .material-title-container, .material-section-content { padding-left: 4vw; padding-right: 4vw; }\n  .material-section-header { font-size:1em; padding-left:2vw; padding-right:2vw;}\n}\n\u003C/style>\n","\u003Cdiv class=\"material-outer-container\">\n  \u003Cdiv class=\"material-title-container\">\n    \u003Ch2 id=\"material",367,"2025-08-04 11:19:14","直肠癌, 奥沙利铂, 卡培他滨, 安全用药, 化疗不良反应, pMMR, 用药指导, 患者教育","本文为您提供奥沙利铂与卡培他滨的使用详解，确保安全用药及有效治疗晚期直肠癌，帮助患者及家属科学管理用药。","2025-08-04 11:56:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]