[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$f51V6YHcDu1ycoPpYoB1QVgh1aqNBHkHVMEHd3bEymP0":8,"$fevLay-J1N3NjKyoQ3tif2ZySyBi2C3KzYXLA2un3AKQ":55,"$fWgYOA5yG9KP-oi7EWILG2opy1H3SsthZRgbOt9RlLW4":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},55227,870371,[],"https://cdn.haohuanjiao.com/learnMaterial/ystApp//BBsCIvgldfowLqXcmUE27AFCz4QmTDjp.png","王德兴","上海市第八人民医院","肿瘤科","副主任医师",6,0,"皮肤鳞状细胞癌常用药品实用指南","","https://ystcdn.venuertc.com/venue/AI/15159490-2fab-4a0d-a2a7-e7aad9840c6a.jpg","\u003Ch1 id=\"material_title\" class=\"guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">皮肤鳞状细胞癌常用药品实用指南\u003C/h1>\n\u003Cdiv class=\"guide-intro\">\n  治疗皮肤鳞状细胞癌的药物种类多样，从局部外用到全身用药各有特点。不同药物在服用（或使用）方法、不良反应防控、用药禁忌上有着诸多细节。本文将通过7个实用要点，为你梳理相关药品在安全使用时需要特别留意的具体做法，帮助你和家人在用药时更安心、有效。\n\u003C/div>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #f6f7f9 0%, #e2eafc 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01 外用药物的剂型和正确使用 🌿\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      局部用药在治疗表浅型皮肤鳞状细胞癌时较为常见，如5-氟尿嘧啶（5-FU）乳膏、咪喹莫特乳膏。此类药剂不需口服，直接涂抹在受影响部位即可。\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>5-氟尿嘧啶（5-FU）乳膏：\u003C/strong>剥脱型作用药物。正确做法：用温水清洁患处，洗净后用棉签或手指薄薄涂布，每日1-2次，用药前后须洗手。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>咪喹莫特乳膏：\u003C/strong>免疫调节剂。正确做法：晚上睡前涂一层薄药，次晨洗净，每周限定次数，遵医嘱操作。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>特别提醒：\u003C/strong>涂药时药膏不要接触正常皮肤或黏膜，尤其避免入眼。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      一位成年患者因长期暴露部位疗程中自行增大量，用药部位出现持续发红、痛痒，经调整至推荐剂量后明显改善。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #e7f0ea 0%, #dbe6e0 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02 外用药物的用药周期与停药判断 ⏳\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      局部用药需要持续一定时间，既不可自行延长，也不可随意缩短疗程。\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>5-FU乳膏：\u003C/strong>常规疗程2-4周。正确做法：完整用毕，不要提前停药，疗程结束后遵医嘱复诊。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>咪喹莫特乳膏：\u003C/strong>推荐单次疗程为6周左右，每周用药天数和间隔时间需严格执行。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>停药原则：\u003C/strong>用药部位严重红肿、糜烂或大面积溃剥时，应及时就医，由专业人员判断是否停止或暂停用药。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      数据显示，规范疗程完成的患者局部复发率显著降低\u003Csup>1\u003C/sup>。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #fffbe7 0%, #f7f8f2 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03 外用药物的常见不良反应和处理办法 😣\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      这些外用药在杀伤异常细胞时，常引起局部反应。常见表现包括发红、刺痛、脱屑、轻度渗出。严重时可出现溃烂、渗血等。\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>5-FU乳膏：\u003C/strong>红斑、干痒、脱皮，非常严重时可能有溃疡。正确做法：出现轻微刺激持续24-48小时后逐渐减轻可继续用药；若剧烈刺痛、流液，暂停涂药并及时就医。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>咪喹莫特乳膏：\u003C/strong>局部炎症、痂皮，一般为可耐受反应。异常疼痛或大块糜烂应立即停药。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      出现严重不良反应需携带药品包装或说明书前往医院就诊，便于医师进一步判断。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #f1eaff 0%, #e5ecee 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04 局部用药的禁忌与注意事项 ⚠️\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      不同药物都有使用限制。有些人群禁用，有些状态下需格外小心。\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>孕妇、哺乳期禁用：\u003C/strong>5-氟尿嘧啶、咪喹莫特等不适合孕妇和哺乳期妇女，因存在致畸或母乳排泄的风险。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>皮肤损伤禁用：\u003C/strong>严重感染、开放伤口、出血区不宜使用外用抗肿瘤乳膏。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>过敏史：\u003C/strong>已知该药成分过敏者禁用，首次使用建议在小范围试涂。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      \u003Cstrong>正确做法：\u003C/strong>不确定能否使用时一定先征求医生意见，不要擅自更改剂量或疗程。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #eafff0 0%, #f4f6fa 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05 系统用药及特殊用药途径 🧴\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      对于侵袭性较强或者扩散的病灶，常需全身治疗。临床主要选用：\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>化疗药物（如紫杉醇、顺铂）：\u003C/strong>多为静脉滴注，需按体表面积或体重计算剂量。正确做法：严格依赖医护团队操作，不得私自调整或终止。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>免疫检查点抑制剂：\u003C/strong>如派姆单抗、纳武利尤单抗。部分晚期患者获益，但需在肿瘤专科严格评估后决定。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      \u003Cstrong>用药案例：\u003C/strong>某位糖尿病合并鳞状细胞癌患者，化疗期间因未按要求监测血糖出现波动，调整后顺利完成疗程。\n    \u003C/p>\n    \u003Cp>\n      \u003Cstrong>特别提醒：\u003C/strong>合并慢性病时，全身用药方案需协同多学科共同管理。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #f8eae6 0%, #f4f0ee 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06 药物相互作用与饮食关系 🍽️\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      很多抗肿瘤药物代谢途径复杂，与常见药品及食物可能产生相互作用。\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>抗肿瘤药和降糖药：\u003C/strong>糖尿病患者化疗期间，降糖药用量需酌情调整，部分化疗药可影响血糖稳定。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>紫杉醇、顺铂：\u003C/strong>宜用大量水送服，治疗前后建议避免高脂高糖饮食。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>外用药：\u003C/strong>与同部位其他外用制剂需间隔30分钟以上，以免相互影响。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      \u003Cstrong>正确做法：\u003C/strong>每新加一种药物都应提前咨询医生和药师，了解是否有禁忌或需调整疗程。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #e6edff 0%, #f3f8fb 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07 储存、过期和漏用处理 🕒\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      不同药品对保存环境有严格要求。妥善保存可保证药效稳定，防止变质。\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>5-氟尿嘧啶、咪喹莫特乳膏：\u003C/strong>需避光、避高温，建议存于25℃以下阴凉干燥处。开封后应在1个月内用完，有凝结、变色、异味应立即弃用。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>注射药品：\u003C/strong>未用完的剂量、用后残液必须丢弃，绝不可二次使用。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>漏服漏涂：\u003C/strong>如1次未按时涂抹，想起后可尽快补用，离下次用药接近则跳过，不得一次多量。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>过期药品：\u003C/strong>不论剩余多少均应丢弃，勿尝试重复利用。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      \u003Cstrong>正确做法：\u003C/strong>药盒、药管开封后及时标日期，明确丢弃时间，避免误用。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Csection class=\"guide-section\" style=\"background: linear-gradient(90deg, #ffeeff 0%, #faf7f4 100%);\">\n  \u003Ch2 class=\"guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">08 用药期间自我监测和就医时机 🩺\u003C/h2>\n  \u003Cdiv class=\"guide-content\">\n    \u003Cp>\n      用药过程中，身体的监控同样重要。异常反应一旦出现，要有判断和行动的意识。\n    \u003C/p>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>局部：\u003C/strong>红肿、疼痛垂直进展加重，伴有渗出或恶臭需立即停药并到医院。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>全身：\u003C/strong>发热、全身皮疹、乏力、呼吸不畅等，不宜自理，应尽快就医。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>长期：\u003C/strong>按医嘱定期复诊，必要时进行实验室复查，确保安全。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      准确记录用药过程中的异常，有助于药师或医生快速调整个人用药方案。\n    \u003C/p>\n  \u003C/div>\n\u003C/section>\n\n\u003Cdiv class=\"guide-summary\">\n  \u003Cstrong>总结：\u003C/strong>\n  \u003Cp>\n    治疗皮肤鳞状细胞癌的药品既丰富又专业，局部涂抹、系统化疗、免疫用药各有要求。最核心的安全细节包括遵守剂量和疗程、不随意联用其他药物、不在特殊人群中轻易使用，以及每天细致监测自己的反应。药物保存和操作环节也绝不可大意。如对自己的用法或效果有疑问，及时咨询医生或药师。合理用药，是每个人安全治疗的基本保障。\n  \u003C/p>\n\u003C/div>\n\n\u003Chr class=\"guide-divider\">\n\n\u003Cdiv class=\"guide-refs\">\n  \u003Cstrong>主要参考文献与资料：\u003C/strong>\n  \u003Col>\n    \u003Cli>Stratigos AJ, Garbe C, Lebbe C, et al. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. \u003Ci>European Journal of Cancer\u003C/i>. 2020;128:60–82. doi:10.1016/j.ejca.2020.01.015.\u003C/li>\n    \u003Cli>Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. \u003Ci>Journal of the American Academy of Dermatology\u003C/i>. 1994;30(5 Pt 1):774–778. doi:10.1016/s0190-9622(94)70126-1.\u003C/li>\n    \u003Cli>National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology: Squamous Cell Skin Cancer. Version 2.2023. \u003Ca href=\"https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1467\" target=\"_blank\">NCCN.org\u003C/a>\u003C/li>\n  \u003C/ol>\n\u003C/div>\n\n\u003Cstyle>\n.guide-title {\n  font-size: 2.4em;\n  color: #23395d;\n  margin-top: 40px;\n  margin-bottom: 18px;\n  font-weight: bold;\n  text-align: center;\n  letter-spacing: 2px;\n  line-height: 1.2;\n  background: linear-gradient(90deg, #ddefff 20%, #f8fafd 100%);\n  padding: 14px 0;\n  border-radius: 8px;\n  box-shadow: 0 2px 8px #eee;\n}\n.guide-intro {\n  font-size: 1.1em;\n  color: #37516a;\n  background: #f6f7fb;\n  padding: 18px 28px;\n  margin-bottom: 25px;\n  border-radius: 8px;\n  line-height: 1.7;\n  box-shadow: 0 1px 4px #ecedf6;\n}\n.guide-section {\n  margin: 26px auto 24px auto;\n  padding: 34px 28px 36px 28px;\n  border-radius: 12px;\n  box-shadow: 0 2px 8px #ebeaf2;\n}\n.guide-subtitle {\n  font-size: 1.3em;\n  color: #19416e;\n  background: rgba(255,255,255,0.48);\n  padding: 8px 22px;\n  border-radius: 8px;\n  margin: 0 0 15px 0;\n  font-weight: 600;\n  letter-spacing: 1px;\n  line-height: 1.25;\n  box-shadow: 0 1px 3px #eee;\n  display: inline-block;\n  min-width: 55%;\n}\n.guide-content {\n  font-size: 1.13em;\n  color: #334358;\n  letter-spacing: 0.02em;\n  margin: 0 0 6px 0;\n  line-height: 2.1;\n}\n.guide-content ul {\n  margin: 18px 0 16px 22px;\n  color: #425e7a;\n}\n.guide-content li {\n  margin-bottom: 6px;\n  line-height: 1.9;\n  font-size: 1em;\n  list-style-type: disc;\n}\n.guide-summary {\n  background: linear-gradient(90deg, #f4f7fb 0%, #eefdff 100%);\n  margin: 24px auto;\n  border-radius: 9px;\n  padding: 18px 27px;\n  color: #2e4053;\n  font-size: 1.09em;\n  line-height: 1.9;\n  box-shadow: 0 1px 3px #e3e4e7;\n}\n.guide-divider {\n  border: 0;\n  border-top: 1.5px solid #dbe2ee;\n  margin: 38px auto 22px auto;\n  width: 78%;\n}\n.guide-refs {\n  background: #f4f8fb;\n  margin: 0 auto 38px auto;\n  border-radius: 8px;\n  padding: 16px 22px 22px 22px;\n  color: #3c5275;\n  font-size: 0.98em;\n  box-shadow: 0 1px 2.2px #e9eaea;\n}\n.guide-refs ol {\n  margin-left: 20px;\n}\n.guide-refs li {\n  margin-bottom: 6px;\n  line-height: 1.65;\n}\n@media (max-width: 700px) {\n  .guide-title {\n    font-size: 1.5em;\n    padding: 9px 0;\n  }\n  .guide-section,\n  .guide-intro,\n  .guide-summary,\n  .guide-refs {\n    padding-left: 12px;\n    padding-right: 12px;\n  }\n}\n\u003C/style>\n\n","\u003Ch1 id=\"material_title\" class=\"guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; ",403,"2025-08-04 10:25:28","皮肤鳞状细胞癌, 外用药物, 不良反应, 药物使用指南, 药物相互作用, 化疗, 免疫检查点抑制剂","本文提供针对皮肤鳞状细胞癌的药品使用实用指南，涵盖外用药物的正确使用、不良反应处理和用药周期，帮助患者安全、有效用药。","2025-08-13 08:14:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]