[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fMvwG-JB7QX4pO5CNiwkIyevhA8DPwq_e9M9cv30w8Cw":8,"$fcPvu3l39yRAJ_0UxXRgkBo20X1QNH4l8pdTlCIwdbp8":55,"$f0lfkfyvXnRzFaiCfdoDjoDY65tnzi7Urk3ng7tXXBNc":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},55105,863254,[],"https://ystcdn.venuertc.com/medical/ystApp/Dlmj9URvs7gXdepZpARivDbqwZwkg06p.png","朱永亮","龙口南山养生谷肿瘤医院","放射科","住院医师",397,0,"聚焦肝癌晚期药物治疗：关键用药指南","","https://cdn.yishi-tong.com/console/store-unknown/Oa2YRB6GFGWhpBkNH4oNjqdcVoIKVmfB.png","\u003Cdiv class=\"liver_drug_guide-container\">\n  \u003Ch2 id=\"material_title\" class=\"liver_drug_guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">聚焦肝癌晚期药物治疗：关键用药指南\u003C/h2>\n  \u003Cdiv class=\"liver_drug_section liver_drug_intro-bg\">\n    \u003Cp>\n      提到肝癌晚期的治疗用药，大家多少会想起那些口服或注射的药物，比如靶向药和免疫药。其实，这些药物虽然名字复杂，用起来的门道却很贴近生活。如何正确用药？什么细节不能忽略？下文会从剂型、服用方法、不良反应、特殊人群使用、药物相互作用、储存与补充等7个方面，用通俗易懂的话，为您一一解答。\n    \u003C/p>\n  \u003C/div>\n\n  \u003C!-- 01 剂型与成分：看懂包装和药品类别 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_typing-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">💊\u003C/span> 01 剂型与成分：看懂包装和药品类别\u003C/h2>\n    \u003Cp>\n      肝癌晚期常用药物包括靶向药（如索拉非尼、仑伐替尼、瑞戈非尼）、免疫检查点抑制剂（如帕博利珠单抗、纳武利尤单抗）及部分化疗药（如奥沙利铂、卡培他滨）。\u003Cbr>\n      \u003Cb>剂型多为：\u003C/b> 片剂（口服）、注射剂（静脉）、胶囊；部分药物如卡培他滨属于片剂，通常需要大量饮水送服，注射剂如奥沙利铂则需在医院静脉点滴。\n      \u003Cbr>\n      \u003Cb>成分类别：\u003C/b> 靶向药主要通过干扰肿瘤细胞的分子信号通路实现抗肿瘤效应；免疫药通过激活机体的免疫反应，帮助人体识别并清除异常细胞。\n    \u003C/p>\n    \u003Cp class=\"liver_drug_guide-tip\">正确做法：用药前请确认手中药物的剂型与成分，详细阅读说明书。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 02 药物作用机制：搞清怎么起效 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_mechanism-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">🔬\u003C/span> 02 药物作用机制：搞清怎么起效\u003C/h2>\n    \u003Cp>\n      \u003Cb>靶向药物\u003C/b>（如索拉非尼）通过阻断肿瘤细胞内关键信号通路，抑制血管生成和细胞生长，从而限制肿瘤扩展\u003Csup>[1]\u003C/sup>。\u003Cbr>\n      \u003Cb>免疫检查点抑制剂\u003C/b>（如PD-1抗体）激活患者自身免疫系统，使其识别并杀伤异常细胞\u003Csup>[2]\u003C/sup>。\u003Cbr>\n      \u003Cb>化疗药\u003C/b>通过破坏细胞的分裂过程，减少异常细胞数量。每种机制决定了药物的适用人群、用药方式和常见不良反应。\n    \u003C/p>\n    \u003Cp class=\"liver_drug_guide-tip\">需要注意：不要混淆药物分类和作用机制。每一种药都有独特的抗肿瘤机制。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 03 服药时间与方法：掌握关键细节 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_time-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">⏰\u003C/span> 03 服药时间与方法：掌握关键细节\u003C/h2>\n    \u003Cul class=\"liver_drug_guide-list\">\n      \u003Cli>\u003Cb>靶向药和部分口服化疗药（如索拉非尼、仑伐替尼、卡培他滨）\u003C/b>：\n        \u003Cul>\n          \u003Cli>口服片剂需整片吞服，不可咬碎或掰断。\u003C/li>\n          \u003Cli>索拉非尼建议空腹服用（餐前1小时或餐后2小时），否则吸收会变差。\u003C/li>\n          \u003Cli>卡培他滨建议餐后30分钟内服用。\u003C/li>\n        \u003C/ul>\n      \u003C/li>\n      \u003Cli>\u003Cb>注射用药（如奥沙利铂、免疫抑制剂）\u003C/b>：\n        \u003Cul>\n          \u003Cli>仅限在医院静脉点滴，由医护人员操作。\u003C/li>\n        \u003C/ul>\n      \u003C/li>\n      \u003Cli>\u003Cb>饮水要求：\u003C/b>服用片剂时，每次需用200-250ml温水吞服，避免与奶、茶、果汁同服。\u003C/li>\n    \u003C/ul>\n    \u003Cp class=\"liver_drug_guide-tip\">特别提醒：不同药物服药时间要求不同，切忌自行更改。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 04 用量与剂量调整：牢记剂量变动的4个场景 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_dosage-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">📏\u003C/span> 04 用量与剂量调整：牢记剂量变动的4个场景\u003C/h2>\n    \u003Col class=\"liver_drug_guide-list\">\n      \u003Cli>遵医嘱调整剂量，不可擅自增减。\u003C/li>\n      \u003Cli>出现明显不适或异常反应时，比如手脚麻木、严重胃肠反应，应及时联系医生评估是否需要减量或暂缓用药。\u003C/li>\n      \u003Cli>体重变化、肝肾功能变动后，部分药物需重新评估剂量。\u003C/li>\n      \u003Cli>老年患者/特殊人群使用时，通常需要酌情减量。\u003C/li>\n    \u003C/ol>\n    \u003Cdiv class=\"liver_drug_guide-case\">\n      \u003Cspan>💡\u003C/span>有位患者长期服用索拉非尼，因出现手足麻木，医生建议调整为每日减半剂量。症状明显改善。\n    \u003C/div>\n    \u003Cp class=\"liver_drug_guide-tip\">正确做法：所有药物剂量调整必须由专业医师判定，自行操作有风险。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 05 药物相互作用：这些药一起吃有风险 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_interaction-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">⚠️\u003C/span> 05 药物相互作用：这些药一起吃有风险\u003C/h2>\n    \u003Cp>\n      \u003Cb>药物之间的相互作用\u003C/b>可能影响疗效或增加副作用风险。靶向药（如索拉非尼、瑞戈非尼）在与以下药物合用时应格外小心：\u003Cbr>\n      \u003C/p>\u003Cul class=\"liver_drug_guide-list\">\n        \u003Cli>抗真菌药（伊曲康唑、氟康唑）可能增加血药浓度，加重不良反应。\u003C/li>\n        \u003Cli>某些抗癫痫药（苯妥英钠、卡马西平）会降低疗效。\u003C/li>\n        \u003Cli>强效酸抑制剂（如奥美拉唑）可能会影响部分靶向药的吸收。\u003C/li>\n        \u003Cli>流程化疗药物的联合方案需在医院进行，由专业医师定方案。\u003C/li>\n      \u003C/ul>\n      \u003Cbr>\n    \u003Cp>\u003C/p>\n    \u003Cp class=\"liver_drug_guide-tip\">正确做法：用药期间主动告知医生和药师所有正在服用的药物（含补品、保健品、草药）。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 06 特殊人群如何安全用药 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_special-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">👥\u003C/span> 06 特殊人群如何安全用药\u003C/h2>\n    \u003Cul class=\"liver_drug_guide-list\">\n      \u003Cli>\u003Cb>高龄患者：\u003C/b>部分药物（如化疗药、靶向药）清除率下降，需调整剂量。观察力减弱时，建议家属帮助监督服药。\u003C/li>\n      \u003Cli>\u003Cb>肝肾功能异常：\u003C/b>多数药物需减少剂量。使用中要定期检查肝肾指标。\u003C/li>\n      \u003Cli>\u003Cb>合并其他慢性病：\u003C/b>如高血压、糖尿病等，部分药物与原有常用药物存在相互影响，用药组合更需谨慎。\u003C/li>\n      \u003Cli>\u003Cb>孕妇和哺乳期女性：\u003C/b>肝癌晚期相关药物通常不推荐使用。如确有需要，须严格权衡风险，遵循医嘱。\u003C/li>\n    \u003C/ul>\n    \u003Cdiv class=\"liver_drug_guide-case\">\n      \u003Cspan>💡\u003C/span>临床上，一位合并慢性肝炎的患者服用仑伐替尼，医生定期检查其肝功，根据化验结果调整剂量，降低肝损风险。\n    \u003C/div>\n    \u003Cp class=\"liver_drug_guide-tip\">需要注意：特殊人群请定期化验，如发现异常应及时反馈医生。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 07 常见不良反应与处理 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_adr-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">🚨\u003C/span> 07 常见不良反应与处理\u003C/h2>\n    \u003Cul class=\"liver_drug_guide-list\">\n      \u003Cli>\u003Cb>靶向药：\u003C/b>\n        \u003Cul>\n          \u003Cli>手足皮肤反应、水肿、乏力、腹泻（发生率约20-30%）\u003Csup>[3]\u003C/sup>。\u003C/li>\n        \u003C/ul>\n      \u003C/li>\n      \u003Cli>\u003Cb>免疫药：\u003C/b>\n        \u003Cul>\n          \u003Cli>皮疹、发热、甲状腺功能异常（频率低于15%），严重时可出现免疫相关不良反应\u003Csup>[4]\u003C/sup>。\u003C/li>\n        \u003C/ul>\n      \u003C/li>\n      \u003Cli>\u003Cb>化疗药：\u003C/b>\n        \u003Cul>\n          \u003Cli>消化道症状（恶心、呕吐）、白细胞或血小板下降、周围神经不适。\u003C/li>\n        \u003C/ul>\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>\n      出现上述反应，轻度时可遵医嘱继续用药并采取对症措施；如出现持续性或严重不适，\u003Cspan class=\"liver_drug_guide-highlight\">务必随机体就医\u003C/span>，切莫自行处理。\n    \u003C/p>\n    \u003Cdiv class=\"liver_drug_guide-case\">\n      \u003Cspan>💡\u003C/span>患者使用瑞戈非尼第2周，出现干咳及皮疹，医师指导增加皮肤护理，适时调整用药时间，不良反应得以缓解。\n    \u003C/div>\n  \u003C/div>\n\n  \u003C!-- 08 用药漏服与过量的应对办法 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_missed-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">⏳\u003C/span> 08 用药漏服与过量的应对办法\u003C/h2>\n    \u003Cul class=\"liver_drug_guide-list\">\n      \u003Cli>\u003Cb>口服药漏服：\u003C/b>若接近下次服药时间，则跳过不补服；不宜一次服两片以补前次。\u003C/li>\n      \u003Cli>\u003Cb>注射药漏用：\u003C/b>联系医院重新预约，不可自行注射。\u003C/li>\n      \u003Cli>\u003Cb>过量服用：\u003C/b>若出现明显不适（如明显乏力、恶心或出血），立即停止用药并就诊。\u003C/li>\n    \u003C/ul>\n    \u003Cp class=\"liver_drug_guide-tip\">正确做法：设定闹钟、服药提醒，减少遗忘。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 09 药物储存与保存注意事项 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_storage-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">📦\u003C/span> 09 药物储存与保存注意事项\u003C/h2>\n    \u003Cul class=\"liver_drug_guide-list\">\n      \u003Cli>药品应密封保存于25℃以下、避免阳光直射的干燥环境。\u003C/li>\n      \u003Cli>皮下注射药品存放需遵医嘱，有的需2-8℃冷藏，运输环节要注意保温。\u003C/li>\n      \u003Cli>拆封药品按说明书剩余有效期服用，勿随意混存、分包转移。\u003C/li>\n      \u003Cli>过期药物请勿自行处理或赠予他人，应交由医疗机构专业回收。\u003C/li>\n    \u003C/ul>\n    \u003Cp class=\"liver_drug_guide-tip\">正确做法：储存环境如有特殊要求要和药师核实。\u003C/p>\n  \u003C/div>\n\n  \u003C!-- 10 小结与用药安全提醒 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_conclusion-bg\">\n    \u003Ch2 class=\"liver_drug_guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">\u003Cspan class=\"liver_drug_icon\">✔️\u003C/span> 10 小结与用药安全提醒\u003C/h2>\n    \u003Cp>\n      总结来看，肝癌晚期相关药物种类多、剂型复杂，安全用药最重要的就是遵医嘱操作。正确掌握药物分类、服用时间、相互作用、常见副作用与应急处置方法，能显著提高用药效果、减少风险。\u003Cbr>\n      特别提醒：\u003Cspan class=\"liver_drug_guide-highlight\">遇到不良反应，不可擅自停药或加药，应立即与专业医师沟通。\u003C/span>\n    \u003C/p>\n    \u003Cp>\n      合理用药，让治疗更安心！遇到疑问，记得随时向医生和药师请教。\n    \u003C/p>\n  \u003C/div>\n\n  \u003C!-- 参考文献 -->\n  \u003Cdiv class=\"liver_drug_section liver_drug_reference-bg\">\n    \u003Ch3 class=\"liver_drug_guide-ref-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">参考文献\u003C/h3>\n    \u003Col class=\"liver_drug_guide-ref-list\">\n      \u003Cli>Llovet, J. M., Ricci, S., Mazzaferro, V., et al. (2008). Sorafenib in advanced hepatocellular carcinoma. The New England Journal of Medicine, 359(4), 378–390. https://doi.org/10.1056/NEJMoa0708857\u003C/li>\n      \u003Cli>El-Khoueiry, A. B., Sangro, B., Yau, T., et al. (2017). Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. The Lancet, 389(10088), 2492–2502. https://doi.org/10.1016/S0140-6736(17)31046-2\u003C/li>\n      \u003Cli>Bruix, J., Qin, S., Merle, P., et al. (2017). Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet, 389(10064), 56–66. https://doi.org/10.1016/S0140-6736(16)32453-9\u003C/li>\n      \u003Cli>Barone, A., Scuderi, S. A., Spano, V., et al. (2020). Immunotherapy in hepatocellular carcinoma: where are we now? Human Vaccines & Immunotherapeutics, 16(2), 333–336. https://doi.org/10.1080/21645515.2019.1662671\u003C/li>\n    \u003C/ol>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.liver_drug_guide-container {\n  max-width: 730px;\n  margin: 36px auto;\n  padding: 26px 16px 40px 16px;\n  background: #fff;\n  border-radius: 12px;\n  box-shadow: 0 4px 18px 0 rgba(70,80,115,0.09);\n  font-family: 'Segoe UI', 'PingFang SC', 'Arial', sans-serif;\n  color: #333;\n}\n.liver_drug_guide-title {\n  font-size: 2.15em;\n  font-weight: 800;\n  letter-spacing: 1.2px;\n  text-align: left;\n  margin-bottom: 40px;\n  margin-top: 8px;\n  color: #264C65;\n}\n\n.liver_drug_icon {\n  font-size: 1.05em;\n  margin-right: 9px;\n  vertical-align: baseline;\n}\n\n.liver_drug_section {\n  border-radius: 10px;\n  padding: 24px 20px 16px 20px;\n  margin-bottom: 32px;\n  box-shadow: 0 2px 8px 0 rgba(0,15,40,0.04);\n  font-size: 1.06em;\n  line-height: 1.87;\n  position: relative;\n}\n.liver_drug_intro-bg {\n  background: linear-gradient(108deg, #F1FAF7 25%, #E6F0FC 90%);\n}\n.liver_drug_typing-bg {\n  background: linear-gradient(98deg, #F9FAFC 60%, #F0F5F9 100%);\n}\n.liver_drug_mechanism-bg {\n  background: linear-gradient(98deg, #F5EFFA 70%, #FAF7F9 100%);\n}\n.liver_drug_time-bg {\n  background: linear-gradient(105deg, #FDFCF6 70%, #F5F7F8 100%);\n}\n.liver_drug_dosage-bg {\n  background: linear-gradient(108deg, #F2F9F5 80%, #FBFAF7 100%);\n}\n.liver_drug_interaction-bg {\n  background: linear-gradient(100deg, #F8F6FC 65%, #F5F7F8 100%);\n}\n.liver_drug_special-bg {\n  background: linear-gradient(95deg, #F4F7FA 60%, #FBFAF4 100%);\n}\n.liver_drug_adr-bg {\n  background: linear-gradient(99deg, #FBF3F5 65%, #EAF8F5 100%);\n}\n.liver_drug_missed-bg {\n  background: linear-gradient(108deg, #F7FAF1 60%, #FAF9FE 100%);\n}\n.liver_drug_storage-bg {\n  background: linear-gradient(104deg, #F8FAF9 55%, #F8F5FB 100%);\n}\n.liver_drug_conclusion-bg {\n  background: linear-gradient(109deg, #F1FCFA 75%, #FAF7F7 100%);\n}\n.liver_drug_reference-bg {\n  background: linear-gradient(100deg, #FAFBFD 60%, #F2F8F9 100%);\n  padding-top: 18px;\n  padding-bottom: 14px;\n  margin-bottom: 12px;\n}\n\n.liver_drug_guide-subtitle {\n  font-size: 1.25em;\n  font-weight: 700;\n  color: #38547C;\n  margin-bottom: 18px;\n  margin-top: 6px;\n  display: flex;\n  align-items: center;\n  letter-spacing: 1px;\n}\n\n.liver_drug_guide-list {\n  padding-left: 18px;\n  margin-left: 4px;\n  margin-bottom: 12px;\n}\n.liver_drug_guide-list li {\n  margin-bottom: 7px;\n}\n.liver_drug_guide-tip {\n  background: #E9F2EA;\n  border-left: 4px solid #71B19A;\n  padding: 8px 12px;\n  margin: 22px 0 5px 0;\n  color: #23754B;\n  border-radius: 5px;\n  font-size: 1em;\n  line-height: 1.7;\n  font-weight: 500;\n}\n.liver_drug_guide-case {\n  background: #F6F2E9;\n  border-left: 4px solid #BEA063;\n  color: #715718;\n  padding: 7px 12px 7px 13px;\n  border-radius: 5px;\n  margin-bottom: 12px;\n  margin-top: 25px;\n  font-size: 0.99em;\n  letter-spacing: 0.1px;\n  display: flex;\n  align-items: flex-start;\n}\n.liver_drug_guide-highlight {\n  color: #BE221A;\n  font-weight: 600;\n  letter-spacing: 0.1em;\n  background: #F4DFE9;\n  border-radius: 3px;\n  padding: 1px 4px 0 4px;\n}\n.liver_drug_guide-ref-title {\n  color: #1A3554;\n  font-size: 1.10em;\n  letter-spacing: 1px;\n  font-weight: 600;\n  margin-bottom: 7px;\n}\n.liver_drug_guide-ref-list {\n  font-size: 0.98em;\n  color: #4A6798;\n  padding-left: 23px;\n  margin-top: 0;\n}\n.liver_drug_guide-ref-list li {\n  margin-bottom: 7px;\n}\n@media (max-width: 599px) {\n  .liver_drug_guide-container { padding: 12px 3px 24px 3px; 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