[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fIr--swV5Tw4rrx7zqucRREYL3Z2EKNZwxzFjPEOmkWg":8,"$fMvmGUBl1V2PuCDB6ztoFRv8OiT2LKZ4lTno1HtXGqPQ":55,"$fQIVmTjZXru4XbYPRxQr7M6Xgo1rBLzdOKWvIFX7dfB8":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},52289,867211,[],"https://ystcdn.venuertc.com/medical/ystApp/FRfzTr7rRcZ9NIepJ9KtSQ9JF0EHCJzK.png","赵念初","新乐市中医医院","肿瘤科","住院医师",186,0,"结肠癌二期化疗方案：患者必知的实用用药指南","","https://ystcdn.venuertc.com/venue/AI/93aa39a7-8edf-4756-8c4e-fcde5eb7499d.jpg","\u003Cdiv class=\"material-container\">\n  \u003Ch1 id=\"material_title\" class=\"material-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">结肠癌二期化疗方案：患者必知的实用用药指南\u003C/h1>\n\n  \u003Cdiv class=\"material-section material-cover-1\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🔑 奥沙利铂与卡培他滨：辅助化疗的核心助手\u003C/h2>\n    \u003Cp class=\"material-text\">\n      说起结肠癌术后辅助化疗，奥沙利铂和卡培他滨这对组合是当下应用最为广泛的药物。它们在“XELOX”方案里配合，用于提升根治手术后的巩固效果。本指南将带你详细了解二期化疗常用药物的作用机理、给药方法、注意事项、不良反应及正确存储，帮你掌握安全用药的每个细节。\n      \u003Cbr>全篇共包含7个关键用药要点，耐心读完，收获会很大。\n    \u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-2\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">💊 药品成分与剂型\u003C/h2>\n    \u003Cp class=\"material-text\">\n      XELOX是由两种成分构成：\n      \u003C/p>\u003Cul class=\"material-list\">\n        \u003Cli>奥沙利铂（Oxaliplatin）：注射用，规格常见为50mg、100mg/瓶。\u003C/li>\n        \u003Cli>卡培他滨（Capecitabine）：口服片剂，每片0.15g或0.5g等多种规格。\u003C/li>\n      \u003C/ul>\n    药理作用决定了这两种药必须规范用法，不同剂型的使用细节需要重点关注。\n    \u003Cp>\u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-3\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">⚙️ 奥沙利铂和卡培他滨的作用机理\u003C/h2>\n    \u003Cp class=\"material-text\">\n      \u003Cstrong>奥沙利铂\u003C/strong>属于第三代铂类药物，通过嵌入DNA，阻止遗传信息复制，从而控制细胞生长。\u003Cbr>\n      \u003Cstrong>卡培他滨\u003C/strong>是一种口服前体药（前药），摄入体内后逐渐转化为有效成分氟尿嘧啶（5-FU）。最终以“障碍DNA和RNA合成”的方式发挥作用。\u003Cbr>\n      两药联用时，优势在于通过不同途径抑制异常细胞分裂，可提升效果，降低单药耐受性风险。\n      \u003Csup>\u003Ca href=\"#ref1\">[1]\u003C/a>\u003C/sup>\n    \u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-4\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">⏰ 正确的用药时间与方法\u003C/h2>\n    \u003Cp class=\"material-text\">\n      不同药物给药方式完全不同，务必严格区分：\n      \u003C/p>\u003Cul class=\"material-list\">\n        \u003Cli>\u003Cstrong>奥沙利铂\u003C/strong>：需在医生指导下静脉输注，每3周一次，常见流程为2小时静滴。\u003C/li>\n        \u003Cli>\u003Cstrong>卡培他滨\u003C/strong>：口服，需在早餐和晚餐后30分钟内用足量温水吞服，不要嚼碎。\u003C/li>\n      \u003C/ul>\n      正确做法：奥沙利铂绝不可私自注射；卡培他滨单次忘服时，需要尽快补服，切忌双倍剂量弥补。\n      \u003Cbr>\n      \u003Cbr>\n      案例：一位老年男患者接受XELOX方案时坚持按时用药，并在每次口服卡培他滨餐后半小时内，未出现明显不适。\n    \u003Cp>\u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-5\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🧑‍⚕️ 常见的不良反应与处理\u003C/h2>\n    \u003Cp class=\"material-text\">\n      药品在体内会产生一定副作用，其中最常见的包括：\n      \u003C/p>\u003Col class=\"material-list\">\n        \u003Cli>\n          \u003Cstrong>奥沙利铂\u003C/strong>：\n          \u003Cul>\n            \u003Cli>手足麻木、口腔或咽喉异感（20-30%可能出现）\u003C/li>\n            \u003Cli>过敏反应、静脉炎症等，需要加强监测\u003C/li>\n            \u003Cli>偶有肝功能异常或白细胞减少\u003C/li>\n          \u003C/ul>\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>卡培他滨\u003C/strong>：\n          \u003Cul>\n            \u003Cli>手足皮炎（潮红、疼痛、脱皮）\u003C/li>\n            \u003Cli>消化道不良反应（恶心、腹泻等发生率约15-20%）\u003C/li>\n            \u003Cli>偶有骨髓抑制导致的白细胞等血细胞减少\u003C/li>\n          \u003C/ul>\n        \u003C/li>\n      \u003C/ol>\n      需要注意：如出现持续严重不适（如手足过度疼痛、恶心呕吐、发热等），应当及时向医生反馈，并酌情调整治疗方案。\n    \u003Cp>\u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-6\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🧴 正确储存药品的方法\u003C/h2>\n    \u003Cp class=\"material-text\">\n      \u003C/p>\u003Cul class=\"material-list\">\n        \u003Cli>\u003Cstrong>奥沙利铂\u003C/strong>：必须放在阴凉、干燥环境，温度控制在15-25℃之间。未开封的药品应避光保存。开瓶后溶液要尽快用完。\u003C/li>\n        \u003Cli>\u003Cstrong>卡培他滨\u003C/strong>：片剂应密封保存，在25℃以下，避免高温和潮湿环境。用药时确保干手取药，防止片剂受潮。\u003C/li>\n      \u003C/ul>\n      过期药品不可继续使用，应按照药房指导妥善处理。\n    \u003Cp>\u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-7\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">⚠️ 化疗期间的特殊用药注意事项\u003C/h2>\n    \u003Cp class=\"material-text\">\n      \u003C/p>\u003Cul class=\"material-list\">\n        \u003Cli>\n          \u003Cstrong>药物相互作用\u003C/strong>：奥沙利铂和卡培他滨均可能与抗凝药（如华法林）、部分抗癫痫药等产生相互作用。若必须同步用药，建议医生指导下根据凝血、肝肾功能等指标动态调整剂量。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>支持用药\u003C/strong>：止吐剂（如昂丹司琼）、维生素B6常作为联合化疗的辅助，可以降低不良反应。按说明书规范使用，不建议自行加减。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>老年患者/肝肾功能障碍者\u003C/strong>：药物代谢减慢，更易蓄积毒性。不宜自行调整药量，任何剂量调整须在医生评估后实施。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cbr>\n      案例：临床观察到部分患者在多药同用时出现药效增强或毒性叠加，经药师干预后规范用药，最终顺利完成疗程。\n    \u003Cp>\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-cover-8\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">📝 用药期间的细节管控与补救措施\u003C/h2>\n    \u003Cp class=\"material-text\">\n      \u003C/p>\u003Cul class=\"material-list\">\n        \u003Cli>\n          \u003Cstrong>漏服处理：\u003C/strong>卡培他滨漏服，发现后当即补服即可，若已接近日常下一次服药，则跳过本次；\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>过量危险：\u003C/strong>任何情况下都不得擅自加量。一旦出现恶心呕吐、手足水肿等异常，应暂停用药及时就医。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cbr>\n      服药期间记录每日用药时间和剂量，是保障疗程顺利的好习惯。\n    \u003Cp>\u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-9\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🎯 总结与安全用药的几个关键提醒\u003C/h2>\n    \u003Cp class=\"material-text\">\n      总体来看，奥沙利铂和卡培他滨作为结肠癌二期化疗的主流药物，剂量设定科学，用药便捷，但必须严格掌握剂型、服法与注意事项；尤其是药物过量、相互作用与不良反应，切莫小觑；\u003Cbr>\n      如果遇到任何异常情况——如持续恶心、严重手足不适或不明原因发热，要及时就医；用药安全第一，关乎整体治疗的成败。\n      \u003Cbr>\u003Cbr>\n      最后，任何用药调整，包括支持或辅助药物，都应在医生和药师的指导下进行。\n    \u003C/p>\n  \u003C/div>\n\n  \u003Cdiv class=\"material-section material-cover-10\">\n    \u003Ch2 class=\"material-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🔗 主要参考文献\u003C/h2>\n    \u003Col class=\"material-ref-list\">\n      \u003Cli id=\"ref1\">Grothey, A., Sobrero, A. F., Nishida, T., Lenz, H. J., & Goldberg, R. M. (2018). \"Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer.\" \u003Ci>New England Journal of Medicine\u003C/i>, 367(17), 1599-1608. DOI:10.1056/NEJMoa040681\u003C/li>\n      \u003Cli>Benson, A. B., Venook, A. P., Al-Hawary, M. M., et al. (2021). NCCN Clinical Practice Guidelines in Oncology: Colon Cancer. \u003Ci>Journal of the National Comprehensive Cancer Network\u003C/i>, 19(8), 996-1022.\u003C/li>\n      \u003Cli>Twelves, C., Wong, A., Nowacki, M. P., et al. (2005). \"Capecitabine as adjuvant treatment for stage III colon cancer.\" \u003Ci>New England Journal of Medicine\u003C/i>, 352, 2696-2704.\u003C/li>\n    \u003C/ol>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.material-container {\n  font-family: \"Arial\", \"Segoe UI\", \"Microsoft Yahei\", sans-serif;\n  margin: 0 auto;\n  max-width: 800px;\n  background: #f7f9fa;\n  border-radius: 16px;\n  box-shadow: 0 3px 12px rgba(0,0,0,.06);\n  padding: 32px 28px 40px 28px;\n  color: #222;\n}\n.material-title {\n  text-align: center;\n  font-size: 2.3em;\n  font-weight: 700;\n  color: #2d3e50;\n  margin-bottom: 36px;\n  letter-spacing: 3px;\n  line-height: 1.4em;\n}\n.material-section {\n  background: #fff;\n  border-radius: 14px;\n  margin-bottom: 32px;\n  box-shadow: 0 1px 5px rgba(50,90,120,.05);\n  padding: 32px 26px 22px 26px;\n  position: relative;\n  border-left: 5px solid #70acc7;\n}\n.material-subtitle {\n  font-size: 1.23em;\n  font-weight: 600;\n  margin-bottom: 18px;\n  letter-spacing: 1.6px;\n  background: linear-gradient(90deg, #d8ebfa 60%, #f0f5fa 90%);\n  color: #3975a6;\n  padding: 13px 22px 13px 15px;\n  border-radius: 12px 12px 12px 0;\n  box-shadow: 0 1px 6px rgba(112, 172, 199, 0.09);\n}\n.material-cover-1 { \n  background: linear-gradient(135deg, #f0f7fa 0%, #f5fafd 100%);\n  border-left-color: #9ccfec;\n}\n.material-cover-2 {background: linear-gradient(109deg, #e9f2f8 0%, #f7fbff 100%);}\n.material-cover-3 {background: linear-gradient(135deg, #d9eef7 0%, #e9f6fc 100%);}\n.material-cover-4 {background: linear-gradient(110deg, #f7fafc 80%, #e1eefa 100%);}\n.material-cover-5 {background: linear-gradient(140deg, #f2f8fa 55%, #d7eaf4 100%);}\n.material-cover-6 {background: linear-gradient(122deg, #e4f1fa 0%, #f7fbff 100%);}\n.material-cover-7 {background: linear-gradient(135deg, #f5fbf7 0%, #e0eaf4 100%);}\n.material-cover-8 {background: linear-gradient(128deg, #eaf5fa 0%, #f7fbfc 100%);}\n.material-cover-9 {background: linear-gradient(135deg, #f5fbf7 0%, #e0eaf4 100%);}\n.material-cover-10 {background: linear-gradient(109deg, #f2f8fc 0%, #e7eef2 100%);}\n.material-text {\n  font-size: 1.08em;\n  line-height: 1.95em;\n  color: #314d59;\n  margin-bottom: 2px;\n  letter-spacing: .1em;\n  padding-left: 0.5em;\n}\n.material-list {\n  margin: 11px 0 20px 22px;\n  padding-left: 8px;\n  color: #46617a;\n  font-size: 1.05em;\n  line-height: 1.86em;\n  letter-spacing: .09em;\n}\n.material-list li {\n  margin-bottom: 3px;\n}\n.material-ref-list {\n  margin-left: 26px;\n  margin-top: 10px;\n  color: #577b94;\n  font-size: 1em;\n  line-height: 1.7em;\n}\n.material-ref-list li {\n  margin-bottom: 7px;\n}\n@media (max-width: 700px) {\n  .material-container { padding: 12px 7px 25px 7px; }\n  .material-section { padding: 16px 7px 16px 12px; }\n  .material-title { font-size: 1.3em; }\n}\n\u003C/style>\n","\u003Cdiv class=\"material-container\">\n  \u003Ch1 id=\"material_title\" class=\"material-title\" style=\"color: rgb(",526,"2025-07-25 10:45:35","结肠癌, 二期化疗, 奥沙利铂, 卡培他滨, 辅助化疗, 不良反应, 用药指南, 安全用药","掌握结肠癌二期化疗的核心药物奥沙利铂与卡培他滨的用法、注意事项及不良反应，确保安全用药与疗效提升。适用于患者及家属。","2025-07-27 23:54:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]