[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fzyL7CpxZr-NOxAgAP-2UZlGSMJ6K-TAwt01JsRimXIA":8,"$f_Spmnp0OMtcVmWEpf2S9pJXwExMuRXnjuvoSJaNEZpk":54,"$fwDCOx3HCqCHjtmkzYZNGKom76bjQodrjtpcMUBlIqx8":58},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":53},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":6,"postsTitle":18,"materialTotal":19,"videoTotal":20,"isConcern":7,"title":21,"coverVertical":22,"coverAcross":23,"content":24,"description":25,"views":26,"likes":20,"isThumbsUp":7,"isCollection":7,"collections":20,"createTime":27,"seoTitle":21,"seoKeywords":28,"seoDescription":29,"shelvesTime":30,"version":31,"menus":32,"menuId":34,"type":41,"quality":52,"commentCount":20,"isComment":41},49093,867611,[],"https://ystcdn.venuertc.com/medical/ystApp/FbrpRyhLTrKKXi2EvCwaM2Ek7BzRnYDI.png","白玉婷","山西省肿瘤医院","住院医师",17,0,"胃癌黏液腺癌常用药品全解：安全用药的7个细节","","https://ystcdn.venuertc.com/venue/AI/58c8f44e-216f-4703-bdf8-519506cb6d9e.jpg","\u003Cdiv class=\"drug-guide-container\">\n  \u003C!-- 文章标题 -->\n  \u003Ch1 id=\"material_title\" class=\"drug-guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">胃癌黏液腺癌常用药品全解：安全用药的7个细节\u003C/h1>\n  \n  \u003C!-- 引入开头段落 -->\n  \u003Cdiv class=\"drug-guide-intro drug-guide-bg\">\n    \u003Cspan class=\"drug-guide-icon\">💊\u003C/span>\n    \u003Cspan>\n      在胃癌黏液腺癌的综合治疗中，化疗药物和免疫治疗药物常常被联合使用。这些药物各有特点，在用法、剂量、相互作用等方面需要特别注意。本文将拆解7个关键用药细节，涵盖化疗、免疫及配套辅助药品，助您在用药时规避风险、提升效果。\n    \u003C/span>\n  \u003C/div>\n  \n  \u003C!-- 01 服药时间与方法 -->\n  \u003Csection class=\"drug-guide-section drug-guide-bg1\">\n    \u003Ch2 class=\"drug-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">01 化疗药物的最佳用药时间和方式\u003C/h2>\n    \u003Cspan class=\"drug-guide-section-icon\">⏰\u003C/span>\n    \u003Cdiv class=\"drug-guide-body\">\n      \u003Cp>\n        化疗药物如\u003Cem>奥沙利铂（Oxaliplatin）\u003C/em>、\u003Cem>卡培他滨（Capecitabine）\u003C/em>等，常用于静脉输注或口服。其正确的使用时间十分关键。例如，奥沙利铂需要在医院经静脉缓慢输入，单次给药时间往往不少于2小时。卡培他滨为口服药片，通常建议随餐或餐后30分钟内服用，有助于减少胃肠不适。喝水送服，避免用果汁或乳制品冲服。\n      \u003C/p>\n      \u003Cp>\n        正确做法：严格按照医生制定的方案执行时间，不私自提前、延后或更改输注速度。口服药物需配足量温水吞服，保证药物吸收。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 02 剂型特点与服用技巧 -->\n  \u003Csection class=\"drug-guide-section drug-guide-bg2\">\n    \u003Ch2 class=\"drug-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">02 剂型选择与服用小技巧\u003C/h2>\n    \u003Cspan class=\"drug-guide-section-icon\">💡\u003C/span>\n    \u003Cdiv class=\"drug-guide-body\">\n      \u003Cp>\n        化疗药物有片剂、注射剂等多种形式。像\u003Cem>卡培他滨\u003C/em>是肠溶片，服用时不可咀嚼、压碎或打开，否则会影响药物释放速度，增加副作用风险。\u003Cem>多西他赛（Docetaxel）\u003C/em>等静脉制剂则只能由专业医护人员操作，患者不宜自行处理。\n      \u003C/p>\n      \u003Cp>\n        服药时，应保证剂型完整。如发现药片变形、发霉，应立即更换，勿自行继续使用。有一位患者曾误将卡培他滨嚼碎后服用，出现了明显的口腔不适，最后更换为完整片剂后症状缓解。饮水以温水为宜，每次不少于150ml，有助于顺利吞服及吸收。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 03 药物相互作用 -->\n  \u003Csection class=\"drug-guide-section drug-guide-bg3\">\n    \u003Ch2 class=\"drug-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">03 不可忽视的药物相互作用\u003C/h2>\n    \u003Cspan class=\"drug-guide-section-icon\">⚠️\u003C/span>\n    \u003Cdiv class=\"drug-guide-body\">\n      \u003Cp>\n        化疗和免疫药物常涉及多种药品配合。比如\u003Cem>卡培他滨\u003C/em>与华法林合用时，会增强后者抗凝作用，增加出血风险。\u003Cem>奥沙利铂\u003C/em>在使用时需避免同时输入含钙、镁的溶液，否则会影响药效。免疫检查点抑制剂如\u003Cem>派姆单抗（Pembrolizumab）\u003C/em>，不建议与活疫苗同步使用。\n      \u003C/p>\n      \u003Cp>\n        部分抗生素、抗癫痫药或中草药（如某些含人参类中药）可加剧化疗药物副作用。\u003Cbr>\n        正确做法：用药前主动告知医生正用的所有药品，包括补品及保健品。如需并用其他药品，遵循医嘱调整时间间隔。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 04 特殊人群用药调整 -->\n  \u003Csection class=\"drug-guide-section drug-guide-bg4\">\n    \u003Ch2 class=\"drug-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">04 针对老年人、肝肾功能异常患者的剂量调整\u003C/h2>\n    \u003Cspan class=\"drug-guide-section-icon\">🧓\u003C/span>\n    \u003Cdiv class=\"drug-guide-body\">\n      \u003Cp>\n        老年患者基础代谢减慢，器官储备功能下降，对化疗药物更敏感。例如，\u003Cem>奥沙利铂\u003C/em>、\u003Cem>多西他赛\u003C/em>等清除速度减慢时，容易出现累积毒性。肾功能不全时，\u003Cem>卡培他滨\u003C/em>应适当减量或暂停使用，否则中毒风险升高。\n      \u003C/p>\n      \u003Cp>\n        正确做法：定期监测肝肾功能和血常规。按照医生建议个体化调整剂量。家属要做好监护，发现异常及时就医。某位56岁患者接受新辅助治疗时就因肾功能减退，遵医嘱将卡培他滨减量，减少了副作用。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 05 常见不良反应管理 -->\n  \u003Csection class=\"drug-guide-section drug-guide-bg5\">\n    \u003Ch2 class=\"drug-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">05 化疗及免疫药品的常见不良反应和处理\u003C/h2>\n    \u003Cspan class=\"drug-guide-section-icon\">😷\u003C/span>\n    \u003Cdiv class=\"drug-guide-body\">\n      \u003Cp>\n        化疗药如\u003Cem>奥沙利铂\u003C/em>容易引发恶心、呕吐、周围神经麻木。统计表明，奥沙利铂相关神经毒性发生率可高达60%。\u003Cem>多西他赛\u003C/em>可能带来脱发和中性粒细胞减少。\u003Cem>卡培他滨\u003C/em>口腔溃疡和手脚麻木较为常见。免疫药品如\u003Cem>帕博利珠单抗\u003C/em>（Pembrolizumab）会引起皮疹、疲乏，以及极少数免疫相关不良反应，如肝炎、甲状腺功能异常。\n      \u003C/p>\n      \u003Cp>\n        出现不良反应时的正确做法：疑似副作用时，第一时间联系主诊医生。自身无法判断严重程度时，切忌自行停药，应等待医生指导。轻微反应可按医嘱临时缓解或调整用药，严重反应需立即停药并就医。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 06 用药禁忌与注意事项 -->\n  \u003Csection class=\"drug-guide-section drug-guide-bg6\">\n    \u003Ch2 class=\"drug-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">06 明确的用药禁忌和重点注意事项\u003C/h2>\n    \u003Cspan class=\"drug-guide-section-icon\">🚫\u003C/span>\n    \u003Cdiv class=\"drug-guide-body\">\n      \u003Cp>\n        化疗药物有一些明确的禁忌。例如：\u003Cem>卡培他滨\u003C/em>禁用于重度肝/肾损伤人群和已知对氟嘧啶类药物过敏者。\u003Cem>奥沙利铂\u003C/em>对含铂药物过敏者禁用。免疫检查点抑制剂\u003Cem>帕博利珠单抗\u003C/em>不适合器官移植患者或曾有自身免疫病史者使用。\n      \u003C/p>\n      \u003Cp>\n        与此同时，对于孕妇，所有上述药物均应慎用或禁用。用药期间须避孕，因这些成分有明确致畸风险。哺乳期患者也应暂停母乳喂养。建议患者用药前务必让医生知晓过敏史、妊娠计划等个人特殊情况。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 07 储存条件及有效期管理 -->\n  \u003Csection class=\"drug-guide-section drug-guide-bg7\">\n    \u003Ch2 class=\"drug-guide-subtitle\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">07 储存与有效期，安全用药“最后一道防线”\u003C/h2>\n    \u003Cspan class=\"drug-guide-section-icon\">📦\u003C/span>\n    \u003Cdiv class=\"drug-guide-body\">\n      \u003Cp>\n        \u003Cem>卡培他滨\u003C/em>片及其他口服抗癌药应存放于干燥、避光、室温（15-25℃）环境中，且需远离儿童能接触的地方。不可转存于分药盒中超过一周，避免交叉污染。开封后若药品吸湿、变色、发霉，须及时废弃。\u003Cem>奥沙利铂\u003C/em>、\u003Cem>多西他赛\u003C/em>等注射剂按说明存放冷藏，使用时检查外观澄清，无沉淀。过期药物不可继续使用，应交由医院药房或指定机构回收处理。\n      \u003C/p>\n      \u003Cp>\n        正确做法：定期核查药品有效期，剩药清点后按公共卫生要求处理，避免因误用导致风险。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n  \n  \u003C!-- 结尾总结 -->\n  \u003Cdiv class=\"drug-guide-summary drug-guide-bg\">\n    \u003Cspan class=\"drug-guide-icon\">🔑\u003C/span>\n    \u003Cspan>\n      总结一下，化疗药和免疫治疗药品在实际使用过程中，每一步都关乎用药效果与安全。准确的服药时间、合适的剂型、良好的储存，都是保障疗效的关键。尤其老年和特殊人群，更要在医生指导下调整剂量，仔细监测副作用。如果对任何用药细节拿不准，建议及时向医生或药师咨询。安全合理用药，是治疗效果提升的基础。\n    \u003C/span>\n  \u003C/div>\n\n  \u003C!-- 文献引用 -->\n  \u003Cdiv class=\"drug-guide-reference\">\n    \u003Ch3 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">References\u003C/h3>\n    \u003Col>\n      \u003Cli>\n        Cassidy, J., Tabernero, J., Twelves, C., Brunet, R., Butts, C., et al. (2002). XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. \u003Cem>Journal of Clinical Oncology\u003C/em>, 22(11), 2084–2091. https://doi.org/10.1200/JCO.2004.08.136\n      \u003C/li>\n      \u003Cli>\n        Gandhi, L., Rodríguez-Abreu, D., Gadgeel, S., Esteban, E., Felip, E., et al. (2018). Pembrolizumab plus chemotherapy in metastatic non–small-cell lung cancer. \u003Cem>New England Journal of Medicine\u003C/em>, 378(22), 2078–2092. https://doi.org/10.1056/NEJMoa1801005\n      \u003C/li>\n      \u003Cli>\n        Vries, E.G.E. de, Meyer, J., & Rosing, H. (2000). Docetaxel: clinical pharmacokinetics and approach to optimal dosing. \u003Cem>Clinical Pharmacokinetics\u003C/em>, 39(6), 385–395. https://doi.org/10.2165/00003088-200039060-00001\n      \u003C/li>\n    \u003C/ol>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n/* 独立样式，防污染全局，命名带有drug-guide-前缀 */\n.drug-guide-container {\n  font-family: \"Helvetica Neue\", Arial, \"Hiragino Sans GB\", \"Microsoft YaHei\", sans-serif;\n  background: #f7f8fa;\n  margin: 0 auto;\n  padding: 36px 20px 36px 20px;\n  max-width: 830px;\n  color: #2e2e38;\n  border-radius: 18px;\n  box-shadow: 0 2px 12px #e3e5eb;\n  position: relative;\n}\n.drug-guide-title {\n  font-size: 2.1em;\n  font-weight: bold;\n  color: #275784;\n  letter-spacing: 1px;\n  margin-bottom: 34px;\n  padding: 20px 0 10px 0;\n  border-bottom: 2px solid #e5e7ed;\n  background: linear-gradient(90deg, #f5fafd 65%, #eaf1fb 95%);\n  border-radius: 8px;\n  text-align: center;\n}\n.drug-guide-intro {\n  display: flex;\n  align-items: flex-start;\n  font-size: 1.1em;\n  padding: 22px 22px 22px 22px;\n  margin-bottom: 30px;\n  border-radius: 10px;\n}\n.drug-guide-icon {\n  font-size: 1.5em;\n  margin-right: 12px;\n  margin-top: 3px;\n}\n.drug-guide-subtitle {\n  font-size: 1.35em;\n  font-weight: bold;\n  color: #226199;\n  margin-bottom: 14px;\n  letter-spacing: 0.5px;\n  padding: 15px 10px 7px 10px;\n  border-left: 5px solid #7abeff;\n  background: rgba(232,240,249,0.67);\n  border-radius: 7px;\n  position: relative;\n}\n.drug-guide-section {\n  margin-bottom: 40px;\n  background: transparent;\n  border-radius: 14px;\n  padding-top: 12px;\n  box-shadow: 0 4px 24px rgba(210,220,240,0.045);\n}\n.drug-guide-section-icon {\n  font-size: 1.15em;\n  margin-left: 9px;\n  vertical-align: sub;\n}\n.drug-guide-body {\n  padding: 16px 22px 10px 23px;\n  line-height: 1.93;\n  font-size: 1.07em;\n}\n.drug-guide-bg {\n  background: linear-gradient(87deg, #fafffe 60%, #f0f3f6 100%);\n  border-radius: 12px;\n}\n.drug-guide-bg1 {\n  background: linear-gradient(100deg, #e8f2f6 35%, #fdfefe 90%);\n}\n.drug-guide-bg2 {\n  background: linear-gradient(100deg, #f9f6e8 10%, #f7fafc 100%);\n}\n.drug-guide-bg3 {\n  background: linear-gradient(100deg, #fbeee7 30%, #fafcfd 90%);\n}\n.drug-guide-bg4 {\n  background: linear-gradient(94deg, #e7f6eb 10%, #f7fafd 90%);\n}\n.drug-guide-bg5 {\n  background: linear-gradient(92deg, #f4e9f1 15%, #fcfafe 100%);\n}\n.drug-guide-bg6 {\n  background: linear-gradient(91deg, #fdebe9 12%, #fcfdfa 90%);\n}\n.drug-guide-bg7 {\n  background: linear-gradient(90deg, #eef2fb 14%, #fbfefa 100%);\n}\n.drug-guide-summary {\n  display: flex;\n  align-items: start;\n  background: linear-gradient(120deg, #eaf4fb 78%, #f8f6fb 100%);\n  color: #30517b;\n  font-size: 1.1em;\n  font-weight: 500;\n  padding: 25px 24px 25px 22px;\n  border-radius: 10px;\n  margin-bottom: 27px;\n  margin-top: 40px;\n  box-shadow: 0 2px 8px #eef5fa;\n}\n.drug-guide-reference {\n  padding: 19px 27px 15px 32px;\n  font-size: 0.97em;\n  background: linear-gradient(94deg, #f0f5fc 70%, #fafafc 100%);\n  border-radius: 10px;\n  color: #4c4e4e;\n  box-shadow: 0 1px 7px #f0f4f8;\n}\n.drug-guide-reference h3 {\n  color: #206db9;\n  font-size: 1.08em;\n  font-weight: bold;\n  margin-bottom: 15px;\n}\n.drug-guide-reference ol {\n  margin-left: 25px;\n  margin-top: 7px;\n}\n.drug-guide-reference li {\n  margin-bottom: 8px;\n  line-height: 1.65;\n}\n@media (max-width: 640px) {\n  .drug-guide-container {\n    padding: 10px 2px 20px 2px;\n    max-width: 100vw;\n    border-radius: 0;\n  }\n  .drug-guide-title {\n    font-size: 1.4em;\n    border-radius: 0;\n    padding: 10px 0 7px 0;\n  }\n  .drug-guide-intro,\n  .drug-guide-section,\n  .drug-guide-summary,\n  .drug-guide-reference {\n    border-radius: 0;\n    padding: 11px 6px 14px 7px;\n    font-size: 1em;\n  }\n  .drug-guide-body {\n    padding: 6px 6px 7px 8px;\n    font-size: 1em;\n  }\n}\n\u003C/style>\n","\u003Cdiv class=\"drug-guide-container\">\n  \u003C!-- 文章标题 -->\n  \u003Ch1 id=\"material_title\" class=\"drug-guide-title",540,"2025-07-15 14:39:41","胃癌, 黏液腺癌, 安全用药, 化疗药物, 免疫治疗","了解胃癌黏液腺癌的治疗方案及用药细节，确保安全用药，提升疗效，适合患者及家属阅读，掌握正确用药方法和注意事项。","2025-07-19 23:52:00",2,[33],{"menuId":34,"menuName":35,"parentId":20,"orderNum":31,"path":36,"component":37,"isFrame":38,"isCache":39,"menuType":40,"visible":41,"status":20,"createDept":6,"remark":22,"createTime":42,"children":43,"columnImage":44,"columnLogo":45,"uncheckedLogo":6,"checkedLogo":6,"isHot":41,"isHome":20,"forceLogin":20,"color":46,"seoTitle":47,"seoKeywords":48,"seoDescription":49,"contentNum":6,"promotionalPoster":50,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":51,"routerPath":36,"componentInfo":37},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":55,"success":53},{"pageNo":41,"pageSize":56,"result":57,"totalSize":20},10,[],{"code":9,"msg":10,"message":6,"data":59,"success":53},{"authors":60,"appraiseDimensionScoresVos":61},[],[]]