[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$fluzlmC4pqQbxMZDE1ZUUdap7c-bGJjcjZ4YGKhpZX4A":8,"$fHM1D4G2SrCpTVbRMprRa3NWKvjGBpNXf_beQgqHIfnA":55,"$ffJOMacRTJ46sXqUeFiUz4OXFilE0s5OVOIlOCAvYhwY":59},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},48683,867568,[],"https://ystcdn.venuertc.com/learnMaterial/ystApp//Qwz6GyCWTi4XHRajDQhvP0c86fSiOy65.png","李文旭","温州老年病医院","肿瘤科","主治医师",317,0,"肝内胆管癌相关药物用药安全实用指南","","https://ystcdn.venuertc.com/venue/AI/92130e95-b81c-4a44-9aef-3ed547868cde.jpg","\u003Cdiv class=\"material-guide-container\">\n  \u003Ch2 id=\"material_title\" class=\"material-guide-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">肝内胆管癌相关药物用药安全实用指南\u003C/h2>\n  \n  \u003Cdiv class=\"material-section material-bg-1\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">1⃣ 主要使用的药品类型介绍\u003C/h2>\n    \u003Cp>在肝内胆管癌的治疗过程中，常用的药物包括化疗药物、靶向药物和免疫抑制剂。本指南将结合用药实例，细致梳理这些药品的使用细节和注意事项。\u003C/p>\n    \u003Cul>\n      \u003Cli>化疗药物：吉西他滨、顺铂、卡培他滨。\u003C/li>\n      \u003Cli>靶向/ADC药物：芦康沙妥珠单抗等。\u003C/li>\n      \u003Cli>免疫药物：斯鲁利单抗为代表。 \u003Cspan class=\"material-emoji\">💉\u003C/span>\u003C/li>\n      \u003Cli>支持用药：地塞米松（抗炎）、头孢曲松（抗感染）等。\u003C/li>\n    \u003C/ul>\n    \u003Cp>本文将围绕这些药物，分模块讲解用药方法、相互作用、不良反应和储存方式等7个关键细节。\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-2\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">2⃣ 用药时间与方法 | 如何正确用药？\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>吉西他滨、顺铂：\u003C/strong> 多数为静脉点滴注射，由医护人员按疗程操作。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>卡培他滨：\u003C/strong> 常为口服片剂，建议与餐后半小时内用温水整片吞服。\u003Cbr>\n        \u003Cspan class=\"material-emoji\">🍽️\u003C/span> 正确做法：勿嚼碎，勿空腹服用，保证规律服药时间。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>芦康沙妥珠单抗、斯鲁利单抗：\u003C/strong> 均为注射制剂，医疗机构内使用，按规定周期给药。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>地塞米松、头孢曲松等支持用药：\u003C/strong> 多以注射方式或口服，依照医生嘱托不自行调整。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>漏服片剂时应尽快补服，但若接近下次服用时间请直接跳过漏服，不可一次服用双倍剂量。\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-3\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">3⃣ 剂型特点和服用小技巧\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>片剂（如卡培他滨）：\u003C/strong> 必须整片吞服，不要掰碎、碾碎或嚼服，避免影响释放效果。\n        \u003Cbr>饮水量建议150-200ml，帮助药物顺利吞咽与吸收。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>静脉注射剂：\u003C/strong> 每次治疗需在医疗机构完成，严禁在家自行使用或注射。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>特殊剂型：\u003C/strong> 如芦康沙妥珠单抗为抗体偶联药物，仅限专业人员配制与输注。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>小贴士：部分化疗药物与餐食同服能减少胃肠道刺激。\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-4\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">4⃣ 常见药物相互作用\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>卡培他滨：\u003C/strong> \u003Cspan class=\"material-emoji\">⚠️\u003C/span> 避免与华法林等抗凝药同服，可能增加出血风险。部分抗酸药（如铝、镁制剂）、某些抗癫痫药、苯妥英及部分抗病毒药物可影响其疗效。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>顺铂、吉西他滨：\u003C/strong> 与氨基糖苷类抗生素（如庆大霉素）、利尿剂等合用需严密监测肾功能。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>免疫和靶向药物：\u003C/strong> 使用时不建议同时服用激素类药物（如大剂量地塞米松），会削弱疗效。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>头孢曲松：\u003C/strong> 禁与钙剂同用（尤其IV滴注），否则可产生沉淀或危及生命的反应。\u003C/li>\n    \u003C/ul>\n    \u003Cp>正确做法：所有药物合用需提前与医生、药师核查，杜绝自行加减药。\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-5\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">5⃣ 特殊人群用药注意事项\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>老年人：\u003C/strong> 代谢减慢，部分化疗药物（如顺铂）易出现肾功能不良，剂量需根据情况下调。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>肝肾功能异常者：\u003C/strong> 卡培他滨、吉西他滨需调整剂量。严重肝损害时部分药物禁用。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>孕妇及哺乳期：\u003C/strong> 所有此类药物均禁用，有生育需求需避孕并与医生沟通。\u003Cspan class=\"material-emoji\">🚼\u003C/span>\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>儿童：\u003C/strong> 相关药品多未批准儿童适应症，必须在专科指导下审慎使用。\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>案例：“一位老年患者调整顺铂剂量后，避免了严重的肾脏不良反应。”\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-6\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">6⃣ 常见不良反应及应对方法\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>吉西他滨：\u003C/strong> 常见骨髓抑制（白细胞下降）、轻度脱发或胃肠反应。若出现持续发热、出血、极度乏力等，应立即就医。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>顺铂：\u003C/strong> 可能导致恶心呕吐、肾脏损害、神经听力损害等，需要规律补液、检测肾功能。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>卡培他滨：\u003C/strong> 容易出现手足皮肤脱落、口腔黏膜炎，需要规律观察双手双足及口腔。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>芦康沙妥珠单抗：\u003C/strong> 可能导致输液反应、口腔咽部不适，不良反应出现时报告医生。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>斯鲁利单抗：\u003C/strong> 需警惕免疫相关的异常反应，如乏力、皮疹等。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>头孢曲松、地塞米松等支持药物：\u003C/strong> 少数人可有过敏、消化道不适。\u003C/li>\n    \u003C/ul>\n    \u003Cp>应对方法：如疑似药物不良反应时，暂停药物并尽快到医院处理，切勿擅自停药。\u003C/p>\n    \u003Cp>案例：“临床上有患者使用卡培他滨期间反馈手足皮肤不适，调整用药及加强皮肤护理后好转。”\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-7\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">7⃣ 储存要求及有效期管理\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>化疗药片：\u003C/strong> 需避光、干燥、室温（20-25℃）保存，防止受潮、受热变质。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>注射剂：\u003C/strong> 医院专门冷藏保存，避免反复开封，开瓶后需尽快使用。\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>如何处理过期药物：\u003C/strong> 不随意丢弃至生活垃圾，送交医院或专业药品回收点。\u003C/li>\n    \u003C/ul>\n    \u003Cp>使用前请核查有效期，剥离包装或袋装后，应在24小时内用完。\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-8\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">8⃣ 漏服与过量处理方法\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>片剂漏服时：\u003C/strong> 补服时间距下次服药间隔大于8小时可立即补上，否则跳过。\u003C/li>\n      \u003Cli>\n        \u003Cstrong>静脉注射/输液漏服：\u003C/strong> 不可自行补药，应联系医生按疗程补做。\u003C/li>\n      \u003Cli>\n        \u003Cstrong>过量处理：\u003C/strong> 有异常反应如呕吐、意识障碍等，立即停药、送医，带上残余药品。\u003C/li>\n    \u003C/ul>\n    \u003Cp>所有药物过量均不宜拖延，及早就医非常关键。\u003C/p>\n    \u003Cp>案例：“患者使用头孢曲松时未留意补液间隔，经指导后严格遵守输药时间，未再发生输液反应。”\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-9\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">9⃣ 常用药物作用机制简介\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>吉西他滨：\u003C/strong> 抑制DNA合成，使细胞无法有效分裂。\u003C/li>\n      \u003Cli>\n        \u003Cstrong>顺铂：\u003C/strong> 搅乱DNA螺旋结构，阻断细胞繁殖。\u003C/li>\n      \u003Cli>\n        \u003Cstrong>卡培他滨：\u003C/strong> 在体内代谢为活性成分后，破坏癌细胞增殖。\u003C/li>\n      \u003Cli>\n        \u003Cstrong>芦康沙妥珠单抗：\u003C/strong> 属抗体药物偶联物，通过抗体将化疗活性载药特定位运送至肿瘤组织。\u003C/li>\n      \u003Cli>\n        \u003Cstrong>斯鲁利单抗：\u003C/strong> 免疫检查点抑制剂，激活机体免疫细胞辨认目标。\u003C/li>\n    \u003C/ul>\n    \u003Cp>每种药物都有其独特机制，合理选择和组合可以相互增强疗效。\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-10\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🔟 全文关键小结与安全用药提示\u003C/h2>\n    \u003Cul>\n      \u003Cli>\n        \u003Cstrong>1. 靶向、化疗、免疫药物应遵医嘱监测和调整。\u003C/strong>\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>2. 规范服药、储存、合用才能最大化提升疗效、降低风险。\u003C/strong>\n      \u003C/li>\n      \u003Cli>\n        \u003Cstrong>3. 出现不良反应不紧张，先停药后就医，千万勿自行盲目更改方案。\u003C/strong>\n      \u003C/li>\n    \u003C/ul>\n    \u003Cp>这些用药细节看似不起眼，却是安全有效治疗的关键。遇到不确定情况，请及时咨询专业医生或药师，避免任何因用药不当带来的问题。\u003C/p>\n    \u003Cp>每一次安全服药，都是对自己和家人的负责。\u003C/p>\n  \u003C/div>\n  \n  \u003Cdiv class=\"material-section material-bg-ref\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">🔖 参考文献\u003C/h2>\n    \u003Col class=\"material-ref-list\">\n      \u003Cli>\n        Valle, J. W., et al. (2010). \"Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.\" \u003Ci>Annals of Oncology\u003C/i>, 21(suppl_5), v159-v161.\n      \u003C/li>\n      \u003Cli>\n        Vogel, A., et al. (2019). \"Biliary tract cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.\" \u003Ci>Annals of Oncology\u003C/i>, 30(6), 871-877.\n      \u003C/li>\n      \u003Cli>\n        Shroff, R. T., et al. (2021). \"Gemcitabine, cisplatin, and nab-paclitaxel for the treatment of advanced biliary tract cancers: A phase 2 clinical trial.\" \u003Ci>JAMA Oncology\u003C/i>, 7(6), 888-894.\n      \u003C/li>\n      \u003Cli>\n        Finn, R. S., et al. (2020). \"Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.\" \u003Ci>New England Journal of Medicine\u003C/i>, 382(20), 1894-1905.\n      \u003C/li>\n    \u003C/ol>\n  \u003C/div>\n\u003C/div>\n\n\u003Cstyle>\n.material-guide-container {\n  font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\n  max-width: 780px;\n  margin: 40px auto 60px auto;\n  padding: 36px 24px 40px 24px;\n  background: #fafafc;\n  border-radius: 16px;\n  box-shadow: 0 4px 24px rgba(60,60,60,0.06);\n}\n.material-guide-title {\n  font-size: 2.25em;\n  font-weight: bold;\n  letter-spacing: 0.04em;\n  color: #2C3E50;\n  margin-bottom: 26px;\n  text-align: center;\n}\n.material-section {\n  margin: 36px 0;\n  padding: 32px 24px 26px 24px;\n  border-radius: 14px;\n  background-position: top right;\n  background-repeat: no-repeat;\n  background-size: 140px 60px;\n  box-shadow: 0 2px 10px rgba(100,120,160,0.05);\n}\n.material-section-title {\n  font-size: 1.4em;\n  font-weight: bold;\n  margin-bottom: 16px;\n  color: #2365AC;\n  letter-spacing: 0.03em;\n}\n.material-emoji {\n  font-size: 1.15em;\n  margin-left: 3px;\n}\n.material-bg-1 { background: linear-gradient(90deg, #f8fafc 80%, #d2f1fa 100%); }\n.material-bg-2 { background: linear-gradient(90deg, #f8fafc 80%, #b0e2f5 100%); }\n.material-bg-3 { background: linear-gradient(90deg, #f9fafb 80%, #e7f6d9 100%); }\n.material-bg-4 { background: linear-gradient(90deg, #faf9fb 80%, #ffe5e0 100%); }\n.material-bg-5 { background: linear-gradient(90deg, #fafcfa 80%, #ffeac1 100%); }\n.material-bg-6 { background: linear-gradient(90deg, #fdfafd 80%, #ebebfa 100%); }\n.material-bg-7 { background: linear-gradient(90deg, #fffefa 80%, #e0f0f4 100%); }\n.material-bg-8 { background: linear-gradient(90deg, #faf8fb 80%, #f9e2f1 100%); }\n.material-bg-9 { background: linear-gradient(90deg, #f9fbfa 80%, #e7f7f2 100%); }\n.material-bg-10 { background: linear-gradient(90deg, #fbfcfa 80%, #e6f0fa 100%); }\n.material-bg-ref { background: #f5f7fa; padding: 28px 18px 18px 18px;}\n.material-section ul {\n  margin-bottom: 10px;\n  margin-left: 18px;\n}\n.material-section ul li {\n  margin: 8px 0 8px 0;\n  font-size: 1.04em;\n  line-height: 1.7;\n}\n.material-section p {\n  margin-bottom: 11px;\n  font-size: 1.04em;\n  color: #374151;\n}\n.material-ref-list {\n  padding-left: 22px;\n  color: #54658C;\n  font-size: 0.98em;\n}\n.material-ref-list li {\n  margin-bottom: 5px;\n}\n@media screen and (max-width: 520px){\n  .material-guide-container {\n    padding: 10px 3px 20px 3px;\n    border-radius: 8px;\n  }\n  .material-section {\n    padding: 18px 6px 12px 6px;\n    border-radius: 6px;}\n}\n\u003C/style>\n","\u003Cdiv class=\"material-guide-container\">\n  \u003Ch2 id=\"material_title\" class=\"material-guide-title\" style=",530,"2025-07-14 13:45:15","肝内胆管癌, 药物用药, 不良反应, 化疗药物, 靶向药物, 用药安全, 免疫药物, 剂量调整","本文提供肝内胆管癌治疗中常用药物的详细用药指南，涵盖药物类型、使用方法、不良反应及储存要求，旨在提升患者用药安全与效果。","2025-07-15 10:52:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":57,"result":58,"totalSize":21},10,[],{"code":9,"msg":10,"message":6,"data":60,"success":54},{"authors":61,"appraiseDimensionScoresVos":62},[],[]]