[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$f65-g5LTUgHIk8dGZIHhGe2pKpxnfW0g-O4HGxk3yxcs":3,"$f88W0ikGTZzCvzNRuFvu-8dgzXij3ikOsBQFKow9LI1k":8,"$fN2PkWvCfiZty33QbpY0RJfiqI2zvw1xs5xxNhdVGnf4":55,"$fNYMh8Fs_kfkGjFXlNCAvyR7vA3a7DzaKH9ABayUvXEQ":58},{"code":4,"msg":5,"message":6,"data":6,"success":7},401,"认证失败，无法访问系统资源",null,false,{"code":9,"msg":10,"message":6,"data":11,"success":54},200,"操作成功",{"id":12,"specialistId":13,"specialistAssistants":14,"profilePhoto":15,"specialistName":16,"hospital":17,"department":18,"postsTitle":19,"materialTotal":20,"videoTotal":21,"isConcern":7,"title":22,"coverVertical":23,"coverAcross":24,"content":25,"description":26,"views":27,"likes":21,"isThumbsUp":7,"isCollection":7,"collections":21,"createTime":28,"seoTitle":22,"seoKeywords":29,"seoDescription":30,"shelvesTime":31,"version":32,"menus":33,"menuId":35,"type":42,"quality":53,"commentCount":21,"isComment":42},47397,868771,[],"https://cdn.yishi-tong.com/console/store-unknown/uF7OMd0P_hB1LaAPsAH23kXFsYY6stA4.png","秦泽敏","长治医学院附属和平医院","肿瘤科","主治医师",10,0,"胃癌姑息化疗与骨转移性肿瘤用药安全指南：七大关键细节","","https://ystcdn.venuertc.com/venue/AI/fb169a17-0aa4-4d55-b7b1-1d979b012f20.jpg","\u003Cdiv class=\"material-drug-wrapper\">\n  \u003Cdiv class=\"material-title-block\">\n    \u003Ch2 id=\"material_title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">胃癌姑息化疗与骨转移性肿瘤用药安全指南：七大关键细节\u003C/h2>\n    \u003Cdiv class=\"material-subdesc\">正确使用化疗药物、生物制剂与骨保护药是提升生活质量和保障安全的前提。这篇指南总结了使用相关药品的七个重要注意事项，尤其适合接受化疗且伴有骨转移治疗的朋友们查阅。 🩺💡\u003C/div>\n  \u003C/div>\n\n  \u003C!-- 01 剂型和成分简介 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#FAFAFA 60%,#EFEFEF 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">1. 常见药品剂型与成分特点\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cp>\n        胃癌姑息化疗常用的药物包括各种化疗药物（如紫杉醇、奥沙利铂、替吉奥等），以及生物制剂（如地诺单抗）。\u003Cbr>\n        \u003Cstrong>化疗药品剂型\u003C/strong>主要有：\n        \u003C/p>\u003Cul>\n          \u003Cli>注射剂（静脉滴注为主）\u003C/li>\n          \u003Cli>片剂和胶囊剂（口服，如替吉奥）\u003C/li>\n        \u003C/ul>\n        \u003Cstrong>骨转移相关的药物\u003C/strong>多为注射剂，如地诺单抗（皮下注射）、唑来膦酸（静脉输注）。\n      \u003Cp>\u003C/p>\n      \u003Cp>\n        不同剂型的使用方式和注意事项不一样，务必遵照说明书或医师指导。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 02 药物作用机制 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#F0F7FA 60%,#ECECED 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">2. 药物作用机制简述 🧬\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>化疗药物\u003C/strong>：例如紫杉醇、奥沙利铂等，直接抑制肿瘤细胞的分裂和增殖，从而实现抗癌效果。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>生物制剂\u003C/strong>：如地诺单抗是单克隆抗体，通过抑制RANKL信号通路，阻止破骨细胞活跃，减少骨质破坏，延缓骨相关并发事件。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>双膦酸盐类\u003C/strong>：如唑来膦酸，通过抑制骨吸收，减少破骨细胞活性，降低骨折和高钙血症风险。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        各类药物的详细机制可参考药品说明书。\u003Cbr>\n        文献参考：Stopeck, A. T. et al. (2010). Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced cancer. \u003Ci>Journal of Clinical Oncology\u003C/i>, 28(35), 5132-5139.\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 03 正确用法用量要点 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#F8EEF8 60%,#F3F3FB 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">3. 正确用法与给药细节\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul>\n        \u003Cli>\n          注射类药品（如奥沙利铂、唑来膦酸、地诺单抗）均由医护人员静脉或皮下注射，不可自行操作。\u003Cbr>\n          \u003Cspan class=\"material-tip\">正确做法：\u003C/span> 按照特定周期注射（例：地诺单抗推荐每4周1次，唑来膦酸通常每3-4周静脉输注）。\n        \u003C/li>\n        \u003Cli>\n          口服剂型如替吉奥、卡培他滨等，需整片吞服，切勿嚼碎或掰断。部分药品需在餐前或餐后服用，详见说明书。\n        \u003C/li>\n        \u003Cli>\n          给药时最好用足量温水（200ml左右）吞服药片，以免药物残留食管造成刺激。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        案例分享：一位62岁男性患者，在接受化疗和地诺单抗治疗时，坚持定期注射和规范用药，获得了较好的骨健康保护效果。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 04 药物相互作用风险 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#F7FDF9 60%,#EDEDED 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">4. 药物相互作用 ⏳\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>化疗药物伴口服药\u003C/strong>：某些辅助药物（如制酸药、抗生素等）可能影响化疗药物吸收或代谢，服用多种药品时需与医生确认。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>骨保护药物互斥\u003C/strong>：地诺单抗与双膦酸盐不能联合应用，同期只能选用一种（\u003Cspan class=\"material-tip\">说明书提示\u003C/span>）。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>钙与维生素D补充剂\u003C/strong>：多采用辅助方式，但需在医生指导下合理搭配，避免过量或影响药效。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        \u003Ci>正确做法：\u003C/i>用药期间主动告知医生正在服用的所有药物、保健品，防止药物间产生不良反应。\n      \u003C/p>\n      \u003Cp>\n        文献参考：Pazdur, R., Wagman, L. D., Camphausen, K. A., & Hoskins, W. J. (2020). \u003Ci>Cancer Management: A Multidisciplinary Approach\u003C/i>. UBM Medica.\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 05 适应症与用药禁忌点 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#F6F2EF 60%,#F6F8FA 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">5. 药品适应症和禁忌要明确\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>适应症：\u003C/strong>所有药品的适应症均应严格依据核准范围。临床常用如地诺单抗、唑来膦酸主要用于肿瘤导致的骨相关事件预防和相关治疗；化疗药物按疗程和周期精准使用。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>常见禁忌：\u003C/strong>\n          \u003Cul>\n            \u003Cli>对本品或辅料过敏者禁用；\u003C/li>\n            \u003Cli>严重肝肾功能障碍者部分药品需避用或减量（如唑来膦酸、卡培他滨）；\u003C/li>\n            \u003Cli>妊娠及哺乳期妇女、未成年人通常不推荐使用骨保护药品或大多数化疗药。\u003C/li>\n          \u003C/ul>\n        \u003C/li>\n        \u003Cli>\n          \u003Cspan class=\"material-tip\">特别提醒：\u003C/span>禁忌症以药品说明书为准，切勿自行判断或贸然加减药品类型。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        案例分享：有患者因无肝肾障碍，成功使用唑来膦酸并配合补钙，未出现明显不适。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 06 常见不良反应与处理 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#F3F8F2 60%,#F9F7F7 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">6. 不良反应及处理措施 🚨\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>化疗药物：\u003C/strong> 常见如恶心、呕吐、白细胞减少等，部分患者可能出现脱发。大部分不良反应可通过对症支持药物缓解。（临床显示白细胞下降发生率达30%-40%）\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>地诺单抗：\u003C/strong> 可能引发下颌骨坏死、低钙血症、皮疹等，应用前须完善血钙检查，并按需补充钙和维生素D。\u003Cbr>\n          \u003Cspan class=\"material-tip\">出现手脚麻木、抽搐、肌肉痛，需及时就医处理。\u003C/span>\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>唑来膦酸：\u003C/strong> 可能导致发热、关节痛、肾功能异常和电解质紊乱，用药前需监测肾功能和血钙水平。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        \u003Ci>出现异常反应或用药不适时，一定要及时与主治医生联系。\u003C/i>\n      \u003C/p>\n      \u003Cp>\n        文献引用：Brufsky, A., et al. (2012). Safety of intravenous bisphosphonates in cancer patients. \u003Ci>Journal of Clinical Oncology\u003C/i>, 30(8), 854-861.\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 07 储存方法与药品有效期 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#EDF6F4 60%,#F5F2F8 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">7. 正确储存及过期药品处理\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>注射剂类：\u003C/strong> 要在2-8℃冷藏保存，避免冷冻，远离强光与潮湿。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>片剂/胶囊：\u003C/strong> 常温避光储存，避免受潮。打开包装后在说明书规定时间内用完。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>过期药品：\u003C/strong> 切勿随意丢弃，建议密封后交由药店或医疗回收点妥善处理，避免污染环境。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        \u003Cspan class=\"material-tip\">正确做法：\u003C/span> 取药时务必检查有效期。过期药易降解或失效，甚至危害健康。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 08 漏服和过量应对办法 -->\n  \u003Csection class=\"material-section\" style=\"background:linear-gradient(90deg,#FEEFF5 60%,#EAF3F6 100%);\">\n    \u003Ch2 class=\"material-section-title\" style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">8. 漏服与过量处理办法\u003C/h2>\n    \u003Cdiv class=\"material-section-content\">\n      \u003Cul>\n        \u003Cli>\n          \u003Cstrong>口服药漏服：\u003C/strong> 记起后尽快补服；如果接近下次服药时间，直接跳过漏服那次，切勿双倍服用。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>注射类药品错过预约：\u003C/strong> 请立即联系医院调整时间，避免自行调整药量或注射频率。\n        \u003C/li>\n        \u003Cli>\n          \u003Cstrong>误服/过量：\u003C/strong> 立即停止服用，妥善保存剩余药物携带至医院就诊，配合医生观察和检查。\n        \u003C/li>\n      \u003C/ul>\n      \u003Cp>\n        \u003Ci>正确做法：\u003C/i>用药出现疑惑或担心剂量，首选联系医师或药师，切勿自作主张增减药量。\n      \u003C/p>\n    \u003C/div>\n  \u003C/section>\n\n  \u003C!-- 总结+安全用药提醒 -->\n  \u003Cdiv class=\"material-conclusion\">\n    \u003Ch2 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">总结：用药安全重于一切\u003C/h2>\n    \u003Cp>\n      胃癌姑息化疗及骨转移相关药品，在提高生活质量、减少并发症方面有着不可替代的作用。但每一次服药、每一个细节，都需要您用心把握。\u003Cbr>\n      \u003Cspan class=\"material-tip\">最关键的两点：\u003C/span> 不随意增减药品、不自行更改用药方案。遇到用药相关的不适或疑问，及时联系专业医生，才能将风险降到最低。🔍\n    \u003C/p>\n    \u003Cp>\n      如需了解更多专业资料或最新药品指南，可查询国际肿瘤药理指南及美国FDA官网。\n    \u003C/p>\n  \u003C/div>\n\n  \u003C!-- 参考文献 -->\n  \u003Cdiv class=\"material-reference\">\n    \u003Ch3 style=\"color: rgb(44, 62, 80); margin: 1.2em 0px 0.6em; font-weight: 700; border-bottom: 1px solid rgb(238, 238, 238);\">主要参考文献\u003C/h3>\n    \u003Cul>\n      \u003Cli>\n        Stopeck, A. T., Lipton, A., Body, J. J., Steger, G. G., Tonkin, K., de Boer, R. H., ... & Jun, S. (2010). Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced cancer. \u003Ci>Journal of Clinical Oncology\u003C/i>, 28(35), 5132-5139.\n      \u003C/li>\n      \u003Cli>\n        Brufsky, A., Bosserman, L., Caradonna, R. R., & Gilloteaux, J. (2012). Safety of intravenous bisphosphonates in cancer patients. \u003Ci>Journal of Clinical Oncology\u003C/i>, 30(8), 854-861.\n      \u003C/li>\n      \u003Cli>\n        Pazdur, R., Wagman, L. D., Camphausen, K. A., & Hoskins, W. J. (2020). \u003Ci>Cancer Management: A Multidisciplinary Approach\u003C/i>. UBM Medica.\n      \u003C/li>\n    \u003C/ul>\n  \u003C/div>\n\u003C/div>\n\n\n\u003Cstyle>\n.material-drug-wrapper {\n  font-family: 'Microsoft YaHei', Arial, Helvetica, sans-serif;\n  color: #262626;\n  background: #F9F9FB;\n  padding: 48px 16px 40px 16px;\n  max-width: 800px;\n  margin: 0 auto;\n  border-radius: 18px;\n  box-shadow: 0 4px 32px rgba(48, 70, 107, 0.08);\n}\n\n.material-title-block {\n  margin-bottom: 28px;\n  text-align: center;\n}\n\n#material_title {\n  font-size: 28px;\n  font-weight: bold;\n  letter-spacing: 1.5px;\n  margin:0 0 14px 0;\n  color: #2D386B;\n}\n\n.material-subdesc {\n  font-size: 16px;\n  color: #686EA8;\n  background: rgba(232,236,250,0.35);\n  display: inline-block;\n  border-radius: 8px;\n  padding: 10px 18px;\n  margin-bottom: 8px;\n}\n\n.material-section {\n  border-radius: 15px;\n  padding: 28px 28px 20px 28px;\n  margin-bottom: 22px;\n  box-shadow: 0 2px 8px rgba(200, 206, 217, 0.11);\n  border-left: 6px solid #C2C6E9;\n  background-repeat: no-repeat;\n  background-size: cover;\n}\n\n.material-section-title {\n  font-size: 20px;\n  color: #4C567D;\n  font-weight: bold;\n  margin-bottom: 12px;\n  display: flex;\n  align-items: center;\n  letter-spacing: 0.5px;\n}\n\n.material-section-content > ul {\n  margin-top: 0;\n  margin-bottom: 10px;\n  padding-left: 18px;\n  line-height: 2.0;\n}\n\n.material-section-content li {\n  margin-bottom: 6px;\n}\n\n.material-section-content p, .material-section-content ul {\n  font-size: 15px;\n  color: #283A4D;\n  line-height: 1.85;\n}\n\n.material-section-content i {\n  color: #746580;\n  font-style: italic;\n}\n\n.material-section-content strong {\n  color: #0D3C54;\n}\n\n.material-tip {\n  background: linear-gradient(90deg, #FFF3E0 40%,#F3EDF6 100%);\n  color: #AC5E33;\n  font-weight: normal;\n  padding: 0 6px;\n  border-radius: 4px;\n  font-size: 14px;\n  margin-right: 4px;\n}\n\n.material-conclusion {\n  background: linear-gradient(90deg,#E1E7F0 70%,#EFEEE9 100%);\n  border-radius: 14px;\n  padding: 28px 28px 20px 28px;\n  margin-top: 38px;\n  margin-bottom: 18px;\n  box-shadow: 0 2px 12px rgba(160, 166, 207, 0.07);\n}\n\n.material-conclusion h2 {\n  font-size: 19px;\n  color: #365388;\n  margin-bottom:10px;\n  font-weight: bold;\n}\n\n.material-conclusion p {\n  font-size: 15px;\n  color: #2E3240;\n  line-height:1.85;\n}\n\n.material-reference {\n  margin-top: 14px;\n  background: #F1F4FA;\n  border-radius: 10px;\n  padding: 17px 22px 8px 22px;\n}\n\n.material-reference h3 {\n  font-size: 16px;\n  color: #4A5A8E;\n  margin-bottom: 10px;\n  font-weight: bold;\n}\n\n.material-reference ul {\n  font-size: 14px;\n  color: #626A7E;\n  padding-left: 20px;\n  margin: 0 0 0 0;\n}\n\n.material-reference li {\n  margin-bottom: 5px;\n  line-height:1.6;\n}\n\u003C/style>\n\n","\u003Cdiv class=\"material-drug-wrapper\">\n  \u003Cdiv class=\"material-title-block\">\n    \u003Ch2 id=\"material_title\"",578,"2025-07-09 10:39:41","胃癌,姑息化疗,骨转移性肿瘤,用药安全,化疗药物,生物制剂,骨保护药","本文提供胃癌姑息化疗与骨转移治疗药物使用的七大关键细节，确保用药安全，提高生活质量。适合正在接受化疗的患者查阅。","2025-07-09 13:14:00",2,[34],{"menuId":35,"menuName":36,"parentId":21,"orderNum":32,"path":37,"component":38,"isFrame":39,"isCache":40,"menuType":41,"visible":42,"status":21,"createDept":6,"remark":23,"createTime":43,"children":44,"columnImage":45,"columnLogo":46,"uncheckedLogo":6,"checkedLogo":6,"isHot":42,"isHome":21,"forceLogin":21,"color":47,"seoTitle":48,"seoKeywords":49,"seoDescription":50,"contentNum":6,"promotionalPoster":51,"menuFrame":7,"innerLink":7,"parentView":7,"routeName":52,"routerPath":37,"componentInfo":38},"1986713082609147906","健康科普","article","/article.html","1","0","T",1,"2025-11-07 16:31:25",[],"https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:49/d4291d16-ed1c-48dd-84c8-ec1f85980b75.png","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:52/6fe64094-9416-442c-a66d-032fb292666a.png","#c8e6ca","健康科普助力健康中国2030:共享健康知识新理念","健康科普, 健康中国, 科普知识, 健康家庭, 性健康, 营养健康, 运动健康, 科普宣传","探索健康科普在健康中国行动中的重要角色,了解最新的健康科普创新大赛、动漫及短视频,传播健康知识,助力全民健康。","https://ystcdn.venuertc.com/venue/undefined/2026-01-24-18:08:56/bd33f471-6c54-4d1b-a364-b06973dbc144.png","Article","癌症肿瘤,重大疾病",true,{"code":9,"msg":10,"message":6,"data":56,"success":54},{"pageNo":42,"pageSize":20,"result":57,"totalSize":21},[],{"code":9,"msg":10,"message":6,"data":59,"success":54},{"authors":60,"appraiseDimensionScoresVos":61},[],[]]